A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis

Toll-like receptors (TLRs) and members of their signaling pathway are important in the initiation of the innate immune response to a wide variety of pathogens. The adaptor protein Mal (also known as TIRAP), encoded by TIRAP (MIM 606252), mediates downstream signaling of TLR2 and TLR4 (refs. 4-6). We report a case-control study of 6,106 individuals from the UK, Vietnam and several African countries with invasive pneumococcal disease, bacteremia, malaria and tuberculosis. We genotyped 33 SNPs, including rs8177374, which encodes a leucine substitution at Ser180 of Mal. We found that heterozygous carriage of this variant associated independently with all four infectious diseases in the different study populations. Combining the study groups, we found substantial support for a protective effect of S180L heterozygosity against these infectious diseases (N = 6,106; overall P = 9.6 x 10(-8)). We found that the Mal S180L variant attenuated TLR2 signal transduction.     

Common genetic variation near MC4R is associated with waist circumference and insulin resistance

We carried out a genome-wide association study (318,237 SNPs) for insulin resistance and related phenotypes in 2,684 Indian Asians, with further testing in 11,955 individuals of Indian Asian or European ancestry. We found associations of rs12970134 near MC4R with waist circumference (P = 1.7 x 10(-9)) and, independently, with insulin resistance. Homozygotes for the risk allele of rs12970134 have approximately 2 cm increased waist circumference. Common genetic variation near MC4R is associated with risk of adiposity and insulin resistance.     

Species diversity enhances ecosystem functioning through interspecific facilitation.

Facilitation between species is thought to be a key mechanism by which biodiversity affects the rates of resource use that govern the efficiency and productivity of ecosystems; however, there is no direct empirical evidence to support this hypothesis. Here we show that increasing the species diversity of a functional group of aquatic organisms induces facilitative interactions, leading to non-additive changes in resource consumption. We increased the richness and evenness of suspension-feeding caddisfly larvae (Insecta, Trichoptera) in stream mesocosms and found that the increased topographical complexity of the benthic habitat alters patterns of near-bed flow such that the feeding success of individuals is enhanced. Species diversity reduces 'current shading' (that is, the deceleration of flow from upstream to downstream neighbours), allowing diverse assemblages to capture a greater fraction of suspended resources than is caught by any species monoculture. The fundamental nature of this form of hydrodynamic facilitation suggests that it is broadly applicable to freshwater and marine habitats; in addition, it has several analogues in terrestrial ecosystems where fluxes of energy and matter can be influenced by biophysical complexity. Thus, changes in species diversity may alter the probability of positive species interactions, resulting in disproportionately large changes in the functioning of ecosystems.     

Macroinvertebrate richness is lower in high-elevation lakes vs nearby streams: evidence from Grand Teton National Park,Wyoming

Mountain ecosystems will be strongly impacted by climate change, yet little is known of extant biodiversity in high-elevation lakes, particularly in North America. In this study, we sampled the littoral zone of six alpine and subalpine lakes in Grand Teton National Park (GRTE), Wyoming, to characterise invertebrate diversity and environmental variation in these climate change-threatened ecosystems. Overall, we collected 19 aquatic invertebrate taxa, and found that each lake harboured a unique assemblage of invertebrates despite close geographic proximity in some instances (e.g. less than 5 km). The results of this study complement previous efforts focused on macroinvertebrate diversity of streams in the Teton Range, highlighting much lower diversity in montane lakes vs nearby streams. Taken together, the two studies establish an important baseline understanding of mountain freshwater biodiversity in GRTE. With rapidly changing hydrologic inputs to mountain lakes driven primarily by the recession of alpine glaciers, these results may help target aquatic invertebrates to monitor as climate change affects the region. Moreover, these data clarify habitat factors, both biotic and abiotic, that influence high-elevation lake assemblages of the Teton Range.