全文获取类型
收费全文 | 204篇 |
免费 | 11篇 |
国内免费 | 11篇 |
专业分类
系统科学 | 9篇 |
现状及发展 | 95篇 |
研究方法 | 17篇 |
综合类 | 100篇 |
自然研究 | 5篇 |
出版年
2022年 | 3篇 |
2021年 | 3篇 |
2019年 | 3篇 |
2018年 | 9篇 |
2017年 | 5篇 |
2016年 | 8篇 |
2015年 | 2篇 |
2014年 | 13篇 |
2013年 | 4篇 |
2012年 | 11篇 |
2011年 | 14篇 |
2010年 | 6篇 |
2009年 | 3篇 |
2008年 | 10篇 |
2007年 | 9篇 |
2006年 | 8篇 |
2005年 | 6篇 |
2004年 | 6篇 |
2003年 | 2篇 |
2002年 | 5篇 |
2000年 | 2篇 |
1992年 | 1篇 |
1991年 | 1篇 |
1990年 | 3篇 |
1989年 | 3篇 |
1988年 | 1篇 |
1987年 | 1篇 |
1986年 | 1篇 |
1985年 | 5篇 |
1984年 | 2篇 |
1983年 | 7篇 |
1982年 | 2篇 |
1981年 | 5篇 |
1980年 | 4篇 |
1979年 | 11篇 |
1978年 | 10篇 |
1977年 | 3篇 |
1976年 | 2篇 |
1975年 | 4篇 |
1974年 | 2篇 |
1973年 | 3篇 |
1971年 | 1篇 |
1970年 | 2篇 |
1969年 | 2篇 |
1968年 | 5篇 |
1967年 | 3篇 |
1963年 | 1篇 |
1962年 | 2篇 |
1959年 | 1篇 |
1957年 | 1篇 |
排序方式: 共有226条查询结果,搜索用时 0 毫秒
11.
Anderson BH Kasher PR Mayer J Szynkiewicz M Jenkinson EM Bhaskar SS Urquhart JE Daly SB Dickerson JE O'Sullivan J Leibundgut EO Muter J Abdel-Salem GM Babul-Hirji R Baxter P Berger A Bonafé L Brunstom-Hernandez JE Buckard JA Chitayat D Chong WK Cordelli DM Ferreira P Fluss J Forrest EH Franzoni E Garone C Hammans SR Houge G Hughes I Jacquemont S Jeannet PY Jefferson RJ Kumar R Kutschke G Lundberg S Lourenço CM Mehta R Naidu S Nischal KK Nunes L Ounap K Philippart M Prabhakar P Risen SR 《Nature genetics》2012,44(3):338-342
Coats plus is a highly pleiotropic disorder particularly affecting the eye, brain, bone and gastrointestinal tract. Here, we show that Coats plus results from mutations in CTC1, encoding conserved telomere maintenance component 1, a member of the mammalian homolog of the yeast heterotrimeric CST telomeric capping complex. Consistent with the observation of shortened telomeres in an Arabidopsis CTC1 mutant and the phenotypic overlap of Coats plus with the telomeric maintenance disorders comprising dyskeratosis congenita, we observed shortened telomeres in three individuals with Coats plus and an increase in spontaneous γH2AX-positive cells in cell lines derived from two affected individuals. CTC1 is also a subunit of the α-accessory factor (AAF) complex, stimulating the activity of DNA polymerase-α primase, the only enzyme known to initiate DNA replication in eukaryotic cells. Thus, CTC1 may have a function in DNA metabolism that is necessary for but not specific to telomeric integrity. 相似文献
12.
Molasses was used as an alternative binder to the bentonite binder. The change in moisture absorption by pellets prepared with different iron ores and different molasses contents were investigated. Iron ore properties exerted the major effect on pellet behavior and final pellet quality. The absorbed moisture content of pellets prepared without binder, bentonite-added pellets, and molasses-added pellets were in the range of 7.72%–9.95%, 9.62%–10.84%, and 6.14%-6.69%, respectively. The wet pellet compressive strength of molasses-added pellets(43–230 N/pellet) was superior to that of bentonite-added pellets(9.47–11.92 N/pellet). The compressive strength of dried molasses-modified pellets increased to 222–394 N/pellet, which is currently the highest value achieved for dried pellets. 相似文献
13.
D. Kumar 《Cellular and molecular life sciences : CMLS》1981,37(1):37-38
Summary Autoradiographic studies using3H-uridine in the salivary gland of adultLygaeus sp. were carried out. The gland cell nuclei, particularly the multiple nucleoli, are the sites of incorporation of the label exhibiting RNA synthesis. The labelled molecules (RNA) are transported to the cell cytoplasm and then into the gland lumen in which no turnover of the radioactivity is observed.I am grateful to my teacher, Prof. P. S. Ramamurty, School of Life Sciences, University of Hyderabad, for his constant inspiration. Grateful acknowledgement is made to Prof. J. P. Thapliyal, Dept of Zoology, B. H. U. for encouragement and to Dr Om Prakash, Dept of Biochemistry, B. H. U. for his valuable criticism. 相似文献
14.
15.
Summary Cyclical variations in acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) levels in foot muscle (FM) and AChE activity in central nervous system (CNS) ofLaevicaulis, during 24-h-day, were maximal at 04.00 h and minimal at 12.00 h. But BuChE activity was 180°C out of phase with AChE in CNS. The rhythmic trend of AChE in CNS might be due to true cholinesterase activity.Acknowledgements. The Senior Fellowship (CSIR) awarded to TPK is thankfully acknowledged. 相似文献
16.
A naturally occurring MTA1 variant sequesters oestrogen receptor-alpha in the cytoplasm 总被引:13,自引:0,他引:13
Kumar R Wang RA Mazumdar A Talukder AH Mandal M Yang Z Bagheri-Yarmand R Sahin A Hortobagyi G Adam L Barnes CJ Vadlamudi RK 《Nature》2002,418(6898):654-657
Oestrogen receptor (ER) is a good prognostic marker for the treatment of breast cancers. Upregulation of metastatic tumour antigen 1 (MTA1) is associated with the invasiveness and metastatic potential of several human cancers and acts as a co-repressor of nuclear ER-alpha. Here we identify a naturally occurring short form of MTA1 (MTA1s) that contains a previously unknown sequence of 33 amino acids with an ER-binding motif, Leu-Arg-Ile-Leu-Leu (LRILL). MTA1s localizes in the cytoplasm, sequesters ER in the cytoplasm, and enhances non-genomic responses of ER. Deleting the LRILL motif in MTA1s abolishes its co-repressor function and its interaction with ER, and restores nuclear localization of ER. Dysregulation of human epidermal growth factor receptor-2 in breast cancer cells enhances the expression of MTA1s and the cytoplasmic sequestration of ER. Expression of MTA1s in breast cancer cells prevents ligand-induced nuclear translocation of ER and stimulates malignant phenotypes. MTA1s expression is increased in human breast tumours with no or low nuclear ER. The regulation of the cellular localization of ER by MTA1s represents a mechanism for redirecting nuclear receptor signalling by nuclear exclusion. 相似文献
17.
Zusammenfassung Bei Kontrolle der Speicheldrüsen ergibt sich, dass die Acridinbehandlung beiDrosophila Komplexinversionen erzeugt. 相似文献
18.
Saran Debasis Kumar Atul Bathula Sivaiah Klaumünzer David Sahu Kisor K 《矿物冶金与材料学报》2022,29(7):1435-1452
19.
Kumar Verandra Thakur Jitendra K. Prasad Manoj 《Cellular and molecular life sciences : CMLS》2021,78(10):4467-4486
Cellular and Molecular Life Sciences - Crop productivity is directly dependent on the growth and development of plants and their adaptation during different environmental stresses. Histone... 相似文献
20.