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J M Nunnari  D L Zimmerman  S C Ogg  P Walter 《Nature》1991,352(6336):638-640
The rough endoplasmic reticulum membranes of mammalian cells contain specific ribosome-binding sites. A purification to apparent homogeneity of a negatively charged protein (ERp180) of relative molecular mass 180,000 (180 K) was reported which was proposed to function as a rough endoplasmic reticulum ribosome receptor. We report here that ribosome-binding site activity quantitatively solubilized from rough endoplasmic reticulum membranes does not cofractionate with ERp180. By contrast, ribosome-binding site activity fractionates as a much smaller, positively charged protein.  相似文献   
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There is considerable debate among scholars over whether Descartes allowed for genuine body–body interaction. I begin by considering Michael Della Rocca’s recent claim that Descartes accepted such interaction, and that his doctrine of the creation of the eternal truths indicates how this interaction could be acceptable to him. Though I agree that Descartes was inclined to accept real bodily causes of motion, I differ from Della Rocca in emphasizing that his ontology ultimately does not allow for them. This is not the end of the story however, since two of Descartes’s successors offered incompatible ways of developing his conflicted account of motion. I contrast the occasionalist view of Nicolas Malebranche that changes in motion derive directly from divine volitions with the non-occasionalist claim of Pierre-Sylvain Regis that such changes derive from a nature distinct from God. In light of Della Rocca’s interpretation, it is noteworthy that the issue of eternal truths is relevant to both alternative accounts. Indeed, Regis took the doctrine that such truths are created to provide crucial support for his alternative to an occasionalist account of body–body interaction. What does not help Della Rocca, however, is that Regis’s view of motion requires a fundamental revision of Descartes’s ontology.  相似文献   
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基于Windows NT的HRPS-Ⅱ设备的控制系统设计   总被引:1,自引:0,他引:1  
介绍了华中科技大学开发的HRPS-Ⅱ型选择性激光烧结设备的体系结构,根据选择性激光烧结的工作原理并结合该系统的硬件结构开发了基于NT操作系统下的控制软件.该控制软件是一种分层的结构,各个不同优先级的任务在不同的层面上运行,实时性强的部分运行在硬件中断级别上,对控制软件的关键性技术进行了描述.通过试验运行,该设备成功地加工出了复杂的原型件,证明控制系统开发是成功的.  相似文献   
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Summary (1) Doubly refracting lipoid droplets can be demonstrated in normal and pathological sera by means of alcohol ether extraction. This is not possible with ether extraction alone.(2) These lipoid droplets can be demonstrated only, or almost only, when they are precipitated out of alcohol or ether alcohol  相似文献   
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Progress on nuclear liquid gas phase transition (LGPT) or critical behavior has been simply reviewed and some signals of LGPT in heavy ion collisions, especially in NIMROD data, are focused. These signals include the power-law charge distribution, the largest fluctuation of the fragment observables, the nuclear Zipf law, caloric curve and critical exponent analysis etc.  相似文献   
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Summary By means of intratracheal injection, particles of metalloid silicium about five microns in size are introduced into the lungs of guinea pigs, and the secondary parenchymatous reactions are studied from 10 minutes to 105 days. In the dust cells, the silicium is progressively broken up into very small particles of less than 1 micron in size. The cells do not show degeneration or mummification as the ordinary silica cells (Mavrogordato) do.  相似文献   
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