全文获取类型
收费全文 | 17749篇 |
免费 | 58篇 |
国内免费 | 88篇 |
专业分类
系统科学 | 74篇 |
丛书文集 | 121篇 |
教育与普及 | 45篇 |
理论与方法论 | 43篇 |
现状及发展 | 7469篇 |
研究方法 | 874篇 |
综合类 | 9070篇 |
自然研究 | 199篇 |
出版年
2013年 | 150篇 |
2012年 | 277篇 |
2011年 | 454篇 |
2009年 | 115篇 |
2008年 | 357篇 |
2007年 | 399篇 |
2006年 | 398篇 |
2005年 | 389篇 |
2004年 | 337篇 |
2003年 | 359篇 |
2002年 | 313篇 |
2001年 | 688篇 |
2000年 | 673篇 |
1999年 | 412篇 |
1994年 | 312篇 |
1992年 | 385篇 |
1991年 | 273篇 |
1990年 | 332篇 |
1989年 | 291篇 |
1988年 | 254篇 |
1987年 | 313篇 |
1986年 | 313篇 |
1985年 | 386篇 |
1984年 | 279篇 |
1983年 | 264篇 |
1982年 | 246篇 |
1981年 | 226篇 |
1980年 | 217篇 |
1979年 | 597篇 |
1978年 | 435篇 |
1977年 | 402篇 |
1976年 | 352篇 |
1975年 | 357篇 |
1974年 | 433篇 |
1973年 | 393篇 |
1972年 | 352篇 |
1971年 | 415篇 |
1970年 | 569篇 |
1969年 | 433篇 |
1968年 | 446篇 |
1967年 | 412篇 |
1966年 | 383篇 |
1965年 | 287篇 |
1959年 | 145篇 |
1958年 | 242篇 |
1957年 | 155篇 |
1956年 | 154篇 |
1955年 | 138篇 |
1954年 | 140篇 |
1948年 | 124篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
361.
362.
363.
Nicole Schwarz Jessica Pruessmeyer Franz M. Hess Daniela Dreymueller Elena Pantaler Anne Koelsch Reinhard Windoffer Matthias Voss Alisina Sarabi Christian Weber Antonio S. Sechi Stefan Uhlig Andreas Ludwig 《Cellular and molecular life sciences : CMLS》2010,67(24):4233-4248
The surface-expressed transmembrane CX3C chemokine ligand 1 (CX3CL1/fractalkine) induces firm adhesion of leukocytes expressing its receptor CX3CR1. After shedding by the disintegrins and metalloproteinases (ADAM) 10 and 17, CX3CL1 also acts as soluble leukocyte chemoattractant. Here, we demonstrate that transmembrane CX3CL1 expressed on both endothelial and epithelial cells induces leukocyte transmigration. To investigate the underlying mechanism, we generated CX3CR1 variants lacking the intracellular aspartate-arginine-tyrosine (DRY) motif or the intracellular C-terminus which led to a defect in intracellular calcium response and impaired ligand uptake, respectively. While both variants effectively mediated firm cell adhesion, they failed to induce transmigration and rather mediated retention of leukocytes on the CX3CL1-expressing cell layer. Targeting of ADAM10 led to increased adhesion but reduced transmigration in response to transmembrane CX3CL1, while transmigration towards soluble CX3CL1 was not affected. Thus, transmembrane CX3CL1 mediates leukocyte transmigration via the DRY motif and C-terminus of CX3CR1 and the activity of ADAM10. 相似文献
364.
Large intergenic non-coding RNA-RoR modulates reprogramming of human induced pluripotent stem cells 总被引:1,自引:0,他引:1
365.
The developmental dynamics of the maize leaf transcriptome 总被引:5,自引:0,他引:5
366.
Genome-wide association studies of 14 agronomic traits in rice landraces 总被引:20,自引:0,他引:20
Huang X Wei X Sang T Zhao Q Feng Q Zhao Y Li C Zhu C Lu T Zhang Z Li M Fan D Guo Y Wang A Wang L Deng L Li W Lu Y Weng Q Liu K Huang T Zhou T Jing Y Li W Lin Z Buckler ES Qian Q Zhang QF Li J Han B 《Nature genetics》2010,42(11):961-967
Uncovering the genetic basis of agronomic traits in crop landraces that have adapted to various agro-climatic conditions is important to world food security. Here we have identified ~ 3.6 million SNPs by sequencing 517 rice landraces and constructed a high-density haplotype map of the rice genome using a novel data-imputation method. We performed genome-wide association studies (GWAS) for 14 agronomic traits in the population of Oryza sativa indica subspecies. The loci identified through GWAS explained ~ 36% of the phenotypic variance, on average. The peak signals at six loci were tied closely to previously identified genes. This study provides a fundamental resource for rice genetics research and breeding, and demonstrates that an approach integrating second-generation genome sequencing and GWAS can be used as a powerful complementary strategy to classical biparental cross-mapping for dissecting complex traits in rice. 相似文献
367.
368.
369.
370.
W.E. Knowles Middleton D.Sc. F.R.S.C. 《Annals of science》2013,70(2):125-141
In 1639–1640 Benedetto Castelli (1577–1643) wrote a treatise on the loadstone which is quite unlike any of its contemporaries. In it are the origins of the notion of elementary magnets sharing a common alignment, the idea that all materials are magnetic in different ways, and the first intimation of the conception of magnetic domains. Castelli did not publish his treatise. Nevertheless his work was noted during his life-time, and may have exerted an influence on the development of magnetic theory in the 17th century. The treatise was published in 1883. Since then, however, it has either been neglected or not appreciated. It deserves being rescued from the neglect of more than three centuries. 相似文献