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411.
Zheng Liu Yuri G. Andreev A. Robert Armstrong Sergio Brutti Yu Ren Peter G. Bruce 《自然科学进展(英文版)》2013,23(3):235-244
Reducing the dimensions of electrode materials from the micron to the nanoscale can have a profound influence on their properties and hence on the performance of electrochemical devices,e.g.Li-ion batteries,that employ such electrodes.TiO2(B) has received growing interest as a possible anode for Li-ion batteries in recent years.It offers the possibility of higher energy storage compared with the commercialized Li4Ti5O12.Bulk,nanowire,nanotube,and nanoparticle morphologies have been prepared and studied.However,to date these materials have not be compared in one article.In the current review we first summarize the different synthesis methods for the preparation of nanostructured TiO2(B);then present the effects of size and shape on the electrochemical properties.Finally TiO2(B) with nanometer dimensions exhibit a higher capacity to store Li,regardless of rate,due to structural distortions inherent at the nanoscale. 相似文献
412.
基于换热过程中的损失率能定量地反映该过程中流体的传热与流动的综合性能这一特性,借助换热过程的损失率方程,分析比较了几种流体工质在不同换热方式下的综合特性。比较结果表明,液体(如水)有远优于气体(如空气)的流动与传热的综合性能,且随着流体温度的升高其优势更为明显。同时表明分析法在定量评价换热工质性能的突出特点及工程上的应用价值。 相似文献
413.
HIV preferentially infects HIV-specific CD4+ T cells 总被引:34,自引:0,他引:34
Douek DC Brenchley JM Betts MR Ambrozak DR Hill BJ Okamoto Y Casazza JP Kuruppu J Kunstman K Wolinsky S Grossman Z Dybul M Oxenius A Price DA Connors M Koup RA 《Nature》2002,417(6884):95-98
HIV infection is associated with the progressive loss of CD4(+) T cells through their destruction or decreased production. A central, yet unresolved issue of HIV disease is the mechanism for this loss, and in particular whether HIV-specific CD4(+) T cells are preferentially affected. Here we show that HIV-specific memory CD4(+) T cells in infected individuals contain more HIV viral DNA than other memory CD4(+) T cells, at all stages of HIV disease. Additionally, following viral rebound during interruption of antiretroviral therapy, the frequency of HIV viral DNA in the HIV-specific pool of memory CD4(+) T cells increases to a greater extent than in memory CD4(+) T cells of other specificities. These findings show that HIV-specific CD4(+) T cells are preferentially infected by HIV in vivo. This provides a potential mechanism to explain the loss of HIV-specific CD4(+) T-cell responses, and consequently the loss of immunological control of HIV replication. Furthermore, the phenomenon of HIV specifically infecting the very cells that respond to it adds a cautionary note to the practice of structured therapy interruption. 相似文献
414.
采用球面刀在三坐标数控机床上加工具有凸曲面工位的零部件时,往往会导致几何形状误差,对此,运用点涉法原理,推导出在凸曲面上确定平头立铣刀五轴和三轴数控联动加工刀位轨迹的计算方法。 相似文献
415.
为了在路面三维图像的基础上快速、准确、完整地识别裂缝,提出一种基于深度学习的路面裂缝类病害自动检测方法.首先,以子块图像为处理单元,将三维图像划分为裂缝面元和背景面元,其中背景面元包含了路面标线、不同纹理和桥接缝等复杂场景.根据对面元图像的分析,提出一种基于卷积神经网络的PCCNet分类模型,用于路面背景面元和路面裂缝... 相似文献
416.
A universal marker for transgenic insects 总被引:16,自引:0,他引:16
417.
1 Results The enantioselective addition of allylic organometallic reagents to aldehydes is a fundamental tool in organic synthesis.The high degree of both diastereo-and enantioselectivity gives the possibility to obtain a wide series of homoallylic alcohols,versatile intermediates in a great number of synthesis[1]. One of the most successful approaches is related to the discovery that organocatalytic activation of the nucleophilic allyltrichlorosilanes by means of neutral Lewis bases,such as formamides,... 相似文献
418.
Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells 总被引:102,自引:0,他引:102
R L Williams D J Hilton S Pease T A Willson C L Stewart D P Gearing E F Wagner D Metcalf N A Nicola N M Gough 《Nature》1988,336(6200):684-687
Embryonic stem (ES) cells, the totipotent outgrowths of blastocysts, can be cultured and manipulated in vitro and then returned to the embryonic environment where they develop normally and can contribute to all cell lineages. Maintenance of the stem-cell phenotype in vitro requires the presence of a feeder layer of fibroblasts or of a soluble factor, differentiation inhibitory activity (DIA) produced by a number of sources; in the absence of DIA the ES cells differentiate into a wide variety of cell types. We recently noted several similarities between partially purified DIA and a haemopoietic regulator, myeloid leukaemia inhibitory factor (LIF), a molecule which induces differentiation in M1 myeloid leukaemic cells and which we have recently purified, cloned and characterized. We demonstrate here that purified, recombinant LIF can substitute for DIA in the maintenance of totipotent ES cell lines that retain the potential to form chimaeric mice. 相似文献
419.
Stem cells, cancer, and cancer stem cells. 总被引:312,自引:0,他引:312
Stem cell biology has come of age. Unequivocal proof that stem cells exist in the haematopoietic system has given way to the prospective isolation of several tissue-specific stem and progenitor cells, the initial delineation of their properties and expressed genetic programmes, and the beginnings of their utility in regenerative medicine. Perhaps the most important and useful property of stem cells is that of self-renewal. Through this property, striking parallels can be found between stem cells and cancer cells: tumours may often originate from the transformation of normal stem cells, similar signalling pathways may regulate self-renewal in stem cells and cancer cells, and cancer cells may include 'cancer stem cells' - rare cells with indefinite potential for self-renewal that drive tumorigenesis. 相似文献
420.
刘浪 《北京理工大学学报》2006,26(Z1):190-194
为了减少目前国民经济动员能力多指标综合评价过程中的主观性,在建立国民经济动员能力评价指标体系的基础上,依据灰色理论的原理,采用灰色变权聚类的方法对它进行综合评价.灰色变权聚类是一种新的计算各指标权重的方法,指标之间的权重在评价过程中会自动产生,不需要经过人为判断确定,能够减少评价过程中的主观因素,比使用层次分析法、模糊综合评价法等方法的结果要更加客观.结合算例,通过专家对各指标进行评估打分,根据评价的过程和结果,对有关单位动员能力水平进行判断,为其动员能力建设提供建议. 相似文献