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81.
Permatasari Yolanda Indah Hardjosoekarto Sudarsono Salomo Roy Valiant 《Systemic Practice and Action Research》2020,33(2):149-165
Systemic Practice and Action Research - This paper provides an example of reconstruction of Public-Private Partnership (PPP) as governance structure at the ministrial level, using a perspective of... 相似文献
82.
The intracellular pathogen Legionella pneumophila modulates the activity of host GTPases to direct the transport and assembly of the membrane-bound compartment in which it resides. In vitro studies have indicated that the Legionella protein DrrA post-translationally modifies the GTPase Rab1 by a process called AMPylation. Here we used mass spectrometry to investigate post-translational modifications to Rab1 that occur during infection of host cells by Legionella. Consistent with in vitro studies, DrrA-mediated AMPylation of a conserved tyrosine residue in the switch II region of Rab1 was detected during infection. In addition, a modification to an adjacent serine residue in Rab1 was discovered, which was independent of DrrA. The Legionella effector protein AnkX was required for this modification. Biochemical studies determined that AnkX directly mediates the covalent attachment of a phosphocholine moiety to Rab1. This phosphocholine transferase activity used CDP-choline as a substrate and required a conserved histidine residue located in the FIC domain of the AnkX protein. During infection, AnkX modified both Rab1 and Rab35, which explains how this protein modulates membrane transport through both the endocytic and exocytic pathways of the host cell. Thus, phosphocholination of Rab GTPases represents a mechanism by which bacterial FIC-domain-containing proteins can alter host-cell functions. 相似文献
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The intestinal absorption and portal vein transport of Na octanoate by isolated jejunal segments perfused in vivo were unchanged in rats studied 48 h after bile duct ligation or fistula. 相似文献
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Summary The intestinal absorption and portal vein transport of Na octanoate by isolate jejunal segments perfused in iivo were unchanged in rats studied 48 h after bile duct ligation or fistula.This work was supported by grant No. MT 4433 from the Medical Research Council of Canada. 相似文献
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Zusammenfassung Aus der Fleischschale der Nüsse vonSapindus laurifolius wurden ausser Hederagenin 2 Triterpene isoliert. Das eine wurde als Oleanolsäure identifiziert, und das andere (Sapindic-Säure) erwies sich als 12 3,23-oxido-oleanen-28-säure. 相似文献
89.
Dixon TH Amelung F Ferretti A Novali F Rocca F Dokka R Sella G Kim SW Wdowinski S Whitman D 《Nature》2006,441(7093):587-588
It has long been recognized that New Orleans is subsiding and is therefore susceptible to catastrophic flooding. Here we present a new subsidence map for the city, generated from space-based synthetic-aperture radar measurements, which reveals that parts of New Orleans underwent rapid subsidence in the three years before Hurricane Katrina struck in August 2005. One such area is next to the Mississippi River-Gulf Outlet (MRGO) canal, where levees failed during the peak storm surge: the map indicates that this weakness could be explained by subsidence of a metre or more since their construction. 相似文献
90.
A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response 总被引:1,自引:0,他引:1
L Kruidenier CW Chung Z Cheng J Liddle K Che G Joberty M Bantscheff C Bountra A Bridges H Diallo D Eberhard S Hutchinson E Jones R Katso M Leveridge PK Mander J Mosley C Ramirez-Molina P Rowland CJ Schofield RJ Sheppard JE Smith C Swales R Tanner P Thomas A Tumber G Drewes U Oppermann DJ Patel K Lee DM Wilson 《Nature》2012,488(7411):404-408