Vergleich der Wirkung des Aldosterons auf das Fremdkörpergranulom der Ratte mit derjenigen von Cortexon,Corticosteron, Cortison und Hydrocortison

Summary Aldosterone applied locally in doses of 50–100 enhances slightly the growth of granuloma and in doses of up to 200 fails to inhibit such growth. In the doses, then, its action differs from that of hydrocortisone, cortisone, and cortexone.     

Ein chemisch neuartiger Vasodilatator mit Wirkung auf die Lungenstrombahn

Summary 4-[5-Amino-3-(4-pyridyl)-1 pyrazolyl]-1-methyl-piperidine (CIBA 31531-Ba) was found to have a relatively pronounced vasodilator effect on the pulmonary circulation in the open chest, right heart-bypass cat with fixed cardiac output. This compound most probably has a direct effect on the vascular smooth muscle.     

Influence of an adrenergicβ-receptor blocking agent on the effect of various hypotensive agents in the hypertensive rat

Zusammenfassung Die hypotensiven Wirkungen von Hydralazin und Guanethidin an renal hypertonischen Ratten konnten für kurze Zeit durch Pronethalol antagonisiert werden. Die Wirkung von-Methyl-DOPA wurde nicht beeinflusst.     

SMC1beta-deficient female mice provide evidence that cohesins are a missing link in age-related nondisjunction

Mitotic chromosome segregation is facilitated by the cohesin complex, which maintains physical connections between sister chromatids until anaphase. Meiotic cell division is considerably more complex, as cohesion must be released sequentially to facilitate orderly segregation of chromosomes at both meiosis I and meiosis II. This necessitates meiosis-specific cohesin components; recent studies in rodents suggest that these influence chromosome behavior during both cell division and meiotic prophase. To elucidate the role of the meiosis-specific cohesin SMC1beta (encoded by Smc1l2) in oogenesis, we carried out meiotic studies of female SMC1beta-deficient mice. Our results provide the first direct evidence that SMC1beta acts as a chiasma binder in mammals, stabilizing sites of exchange until anaphase. Additionally, our observations support the hypothesis that deficient cohesion is an underlying cause of human age-related aneuploidy.     

Photoperiodic induction of synchronous flowering near the Equator

In tropical rainforests, 30-65% of tree species grow at densities of less than one individual per hectare. At these low population densities, successful cross-pollination relies on synchronous flowering. In rainforests with low climatic seasonality, photoperiodic control is the only reliable mechanism for inducing synchronous flowering. This poses a problem because there is no variation in day length at the Equator. Here we propose a new mechanism of photoperiodic timekeeping based on the perception of variation in sunrise or sunset time, which explains and predicts the annually repeated, staggered, synchronous and bimodal flowering of many tree species in Amazonian rainforests near the Equator.     

Schutzwirkung von polysaccharidartigen Fraktionen bakterieller Herkunft bei einer experimentellen Virusinfektion

Summary A polysaccharide like substance derived from cultivated bacteria is shown to exert a protective effect in mice infected with SK.-Col. Encephalomyelitis. The effect is optimally produced when the substance is applied previous to the infection. Certain changes in sera treated with the substance are observed involving normal virucidal factors of the sera.     

Spezifische Wirkung einiger tierischer und bakterieller Polysaccharide auf Leucocytenin vitro

Summary Different purified polysaccharides, mucopolysaccharides, phosphatides and carbohydrat-sulfonic acids have been investigated for their effect on stimulation of leucocytic migrationin vitro. The bacterial polysaccharides of proteus,S. marcescens, shiga and shiga fullantigen, have been found to be of high specific activity. All other compounds have much less or no activity. Therefore it might be concluded that the type of bacterial polysaccharides which promote leucocytic migration belong to a highly specific group.