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101.
氯接触池中溶质输移与消毒过程的数值模拟 总被引:1,自引:0,他引:1
为使饮用水处理中氯接触池达到较高的掺混和消毒效率 ,提出一种数学模拟方法。采用二维水流动量方程和连续方程、自由氯的反应过程一阶动力学方程和细菌数量衰减过程的 Chick- Watson公式等组成的模型 ,计算了氯接触池中溶质输移与消毒过程。对 3种涡粘性湍流模型与 3种差分格式的不同组合下计算所得到的多组模拟结果进行了分析 ,并与试验数据进行了比较。研究表明 :通过数值方法对池内的水流紊动结构及自由氯输运、反应和细菌生灭等过程进行计算模拟 ,与仅依据不同设计方案所得滞留曲线进行评价的做法相比 ,更有利于比较内部细节的设计 ,方便地判定不同设计方案的运行效率 相似文献
102.
Roger Burggraeve 《Foundations of Science》2016,21(2):301-304
Drawing on Victor Frankl’s observations, this comment illustrates how human beings are prior to any initiative that is pre-directed towards meaning. In pointing to this human condition, it introduces a subtle distinction between striving for happiness and a will for meaning, yet it is in the trans-ethical meaningful acts that a relation can be found with the wit(h)nessing as referred to by Note and Van Daele. 相似文献
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104.
Roger J. Bowden 《Journal of forecasting》1989,8(2):117-127
The range and rationales for forecasting schemes involving feedback are surveyed. Classic Delphi schemes involve an iterated exchange of information between a small group of experts in the pursuit of efficiencies arising from the ‘collective mind’. In other applications the event or state to be forecast may itself depend upon the forecast, and feedback forecasting schemes can be derived to allow for such reflexivity. Most situations of informational feedback are at least implicitly informational or predictive games, and a recognition of this character may help in understanding the possible or likely outcomes, including their social desirability. Various informational transfer devices such as real time surveys may speed up the process of feedback. 相似文献
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A long-standing issue in ecology is reconciling the apparent stability of many populations with robust predictions of large-amplitude population cycles from general theory on consumer-resource interactions. Even when consumers are decoupled from dynamic resources, large-amplitude cycles can theoretically emerge from delayed feedback processes found in many consumers. Here we show that resource-dependent mortality and a dynamic developmental delay in consumers produces a new type of small-amplitude cycle that coexists with large-amplitude fluctuations in coupled consumer-resource systems. A distinctive characteristic of the small-amplitude cycles is slow juvenile development for consumers, leading to a developmental delay that is longer than the cycle period. By contrast, the period exceeds the delay in large-amplitude cycles. These theoretical predictions may explain previous empirical results on coexisting attractors found in Daphnia-algal systems. To test this, we used bioassay experiments that measure the growth rates of individuals in populations exhibiting each type of cycle. The results were consistent with predictions. Together, the new theory and experiments establish that two very general features of consumers--a resource-dependent juvenile stage duration and resource-dependent mortality--combine to produce small-amplitude resource-consumer cycles. This phenomenon may contribute to the prevalence of small-amplitude fluctuations in many other consumer-resource populations. 相似文献
108.
Wang PY Caspi L Lam CK Chari M Li X Light PE Gutierrez-Juarez R Ang M Schwartz GJ Lam TK 《Nature》2008,452(7190):1012-1016
Energy and glucose homeostasis are regulated by food intake and liver glucose production, respectively. The upper intestine has a critical role in nutrient digestion and absorption. However, studies indicate that upper intestinal lipids inhibit food intake as well in rodents and humans by the activation of an intestine-brain axis. In parallel, a brain-liver axis has recently been proposed to detect blood lipids to inhibit glucose production in rodents. Thus, we tested the hypothesis that upper intestinal lipids activate an intestine-brain-liver neural axis to regulate glucose homeostasis. Here we demonstrate that direct administration of lipids into the upper intestine increased upper intestinal long-chain fatty acyl-coenzyme A (LCFA-CoA) levels and suppressed glucose production. Co-infusion of the acyl-CoA synthase inhibitor triacsin C or the anaesthetic tetracaine with duodenal lipids abolished the inhibition of glucose production, indicating that upper intestinal LCFA-CoAs regulate glucose production in the preabsorptive state. Subdiaphragmatic vagotomy or gut vagal deafferentation interrupts the neural connection between the gut and the brain, and blocks the ability of upper intestinal lipids to inhibit glucose production. Direct administration of the N-methyl-d-aspartate ion channel blocker MK-801 into the fourth ventricle or the nucleus of the solitary tract where gut sensory fibres terminate abolished the upper-intestinal-lipid-induced inhibition of glucose production. Finally, hepatic vagotomy negated the inhibitory effects of upper intestinal lipids on glucose production. These findings indicate that upper intestinal lipids activate an intestine-brain-liver neural axis to inhibit glucose production, and thereby reveal a previously unappreciated pathway that regulates glucose homeostasis. 相似文献
109.
Sexual mimicry among animals is widespread, but does it impart a fertilization advantage in the widely accepted 'sneak-guard' model of sperm competition? Here we describe field results in which a dramatic facultative switch in sexual phenotype by sneaker-male cuttlefish leads to immediate fertilization success, even in the presence of the consort male. These results are surprising, given the high rate at which females reject copulation attempts by males, the strong mate-guarding behaviour of consort males, and the high level of sperm competition in this complex mating system. 相似文献
110.
Aminoglycoside antibiotics induce bacterial biofilm formation 总被引:2,自引:0,他引:2
Biofilms are adherent aggregates of bacterial cells that form on biotic and abiotic surfaces, including human tissues. Biofilms resist antibiotic treatment and contribute to bacterial persistence in chronic infections. Hence, the elucidation of the mechanisms by which biofilms are formed may assist in the treatment of chronic infections, such as Pseudomonas aeruginosa in the airways of patients with cystic fibrosis. Here we show that subinhibitory concentrations of aminoglycoside antibiotics induce biofilm formation in P. aeruginosa and Escherichia coli. In P. aeruginosa, a gene, which we designated aminoglycoside response regulator (arr), was essential for this induction and contributed to biofilm-specific aminoglycoside resistance. The arr gene is predicted to encode an inner-membrane phosphodiesterase whose substrate is cyclic di-guanosine monophosphate (c-di-GMP)-a bacterial second messenger that regulates cell surface adhesiveness. We found that membranes from arr mutants had diminished c-di-GMP phosphodiesterase activity, and P. aeruginosa cells with a mutation changing a predicted catalytic residue of Arr were defective in their biofilm response to tobramycin. Furthermore, tobramycin-inducible biofilm formation was inhibited by exogenous GTP, which is known to inhibit c-di-GMP phosphodiesterase activity. Our results demonstrate that biofilm formation can be a specific, defensive reaction to the presence of antibiotics, and indicate that the molecular basis of this response includes alterations in the level of c-di-GMP. 相似文献