“Who” is a “Topical Measuring” Postphenomenologist and How Does One Get That Way?

Gert Goeminne’s paper is primarily concerned with “the politics of sustainable technology,” but for good reasons he does not start with this topic. He knows that technology studies as he conceives it must clear a space for itself in a philosophical atmosphere that discourages its pursuit. He therefore begins with a critique of this objectivistic and technocratically defined atmosphere, before moving on to embrace a postphenomenology of technological multistabilities, and then further to introduce what he calls (in an adaptation of Rudolf Boehm) the “topical measure” of technoscientific life. The problem I raise is not about Goeminne’s aims, with which I mostly agree, but with his presentation of how to achieve them. I argue that if one were actually to follow his advice—that is, start with critique, move on to postphenomenology, and end with “political” evaluation of technoscientific life, the project would be doomed to failure. For in our world, no one Understands this pluralizing vision. According to the understanding we actually live through and speak from, some of postphenomenology’s multiple disclosures already arrive in our experience with significantly greater ontological power than others, and sincerity about topical measure notwithstanding, the very identification of something as an interest or “value,” especially if it allegedly comes from a “layperson,” already condemns it to secondary status.     

Inverse computation and the Universal Resolving Algorithm

We survey fundamental concepts for inverse programming and then present the Universal Resolving Algorithm, an algorithm for inverse computation in a first-order, functional programming language. We discuss the key concepts of the algorithm, including a three-step approach based on the notion of a perfect process tree, and demonstrate our implementation with several examples of inverse computation.     

Human embryonic stem cell lines derived from single blastomeres

The derivation of human embryonic stem (hES) cells currently requires the destruction of ex utero embryos. A previous study in mice indicates that it might be possible to generate embryonic stem (ES) cells using a single-cell biopsy similar to that used in preimplantation genetic diagnosis (PGD), which does not interfere with the embryo's developmental potential. By growing the single blastomere overnight, the resulting cells could be used for both genetic testing and stem cell derivation without affecting the clinical outcome of the procedure. Here we report a series of ten separate experiments demonstrating that hES cells can be derived from single blastomeres. In this proof-of-principle study, multiple biopsies were taken from each embryo using micromanipulation techniques and none of the biopsied embryos were allowed to develop in culture. Nineteen ES-cell-like outgrowths and two stable hES cell lines were obtained. The latter hES cell lines maintained undifferentiated proliferation for more than eight months, and showed normal karyotype and expression of markers of pluripotency, including Oct-4, SSEA-3, SSEA-4, TRA-1-60, TRA-1-81, nanog and alkaline phosphatase. These cells retained the potential to form derivatives of all three embryonic germ layers both in vitro and in teratomas. The ability to create new stem cell lines and therapies without destroying embryos would address the ethical concerns of many, and allow the generation of matched tissue for children and siblings born from transferred PGD embryos.     

Driven coherent oscillations of a single electron spin in a quantum dot

The ability to control the quantum state of a single electron spin in a quantum dot is at the heart of recent developments towards a scalable spin-based quantum computer. In combination with the recently demonstrated controlled exchange gate between two neighbouring spins, driven coherent single spin rotations would permit universal quantum operations. Here, we report the experimental realization of single electron spin rotations in a double quantum dot. First, we apply a continuous-wave oscillating magnetic field, generated on-chip, and observe electron spin resonance in spin-dependent transport measurements through the two dots. Next, we coherently control the quantum state of the electron spin by applying short bursts of the oscillating magnetic field and observe about eight oscillations of the spin state (so-called Rabi oscillations) during a microsecond burst. These results demonstrate the feasibility of operating single-electron spins in a quantum dot as quantum bits.     

Influence of the thalamus on spatial visual processing in frontal cortex

Each of our movements activates our own sensory receptors, and therefore keeping track of self-movement is a necessary part of analysing sensory input. One way in which the brain keeps track of self-movement is by monitoring an internal copy, or corollary discharge, of motor commands. This concept could explain why we perceive a stable visual world despite our frequent quick, or saccadic, eye movements: corollary discharge about each saccade would permit the visual system to ignore saccade-induced visual changes. The critical missing link has been the connection between corollary discharge and visual processing. Here we show that such a link is formed by a corollary discharge from the thalamus that targets the frontal cortex. In the thalamus, neurons in the mediodorsal nucleus relay a corollary discharge of saccades from the midbrain superior colliculus to the cortical frontal eye field. In the frontal eye field, neurons use corollary discharge to shift their visual receptive fields spatially before saccades. We tested the hypothesis that these two components-a pathway for corollary discharge and neurons with shifting receptive fields-form a circuit in which the corollary discharge drives the shift. First we showed that the known spatial and temporal properties of the corollary discharge predict the dynamic changes in spatial visual processing of cortical neurons when saccades are made. Then we moved from this correlation to causation by isolating single cortical neurons and showing that their spatial visual processing is impaired when corollary discharge from the thalamus is interrupted. Thus the visual processing of frontal neurons is spatiotemporally matched with, and functionally dependent on, corollary discharge input from the thalamus. These experiments establish the first link between corollary discharge and visual processing, delineate a brain circuit that is well suited for mediating visual stability, and provide a framework for studying corollary discharge in other sensory systems.     

Proteome survey reveals modularity of the yeast cell machinery

Protein complexes are key molecular entities that integrate multiple gene products to perform cellular functions. Here we report the first genome-wide screen for complexes in an organism, budding yeast, using affinity purification and mass spectrometry. Through systematic tagging of open reading frames (ORFs), the majority of complexes were purified several times, suggesting screen saturation. The richness of the data set enabled a de novo characterization of the composition and organization of the cellular machinery. The ensemble of cellular proteins partitions into 491 complexes, of which 257 are novel, that differentially combine with additional attachment proteins or protein modules to enable a diversification of potential functions. Support for this modular organization of the proteome comes from integration with available data on expression, localization, function, evolutionary conservation, protein structure and binary interactions. This study provides the largest collection of physically determined eukaryotic cellular machines so far and a platform for biological data integration and modelling.     

Discovery of two young brown dwarfs in an eclipsing binary system

Brown dwarfs are considered to be 'failed stars' in the sense that they are born with masses between the least massive stars (0.072 solar masses, M(o)) and the most massive planets (approximately 0.013M(o)); they therefore serve as a critical link in our understanding of the formation of both stars and planets. Even the most fundamental physical properties of brown dwarfs remain, however, largely unconstrained by direct measurement. Here we report the discovery of a brown-dwarf eclipsing binary system, in the Orion Nebula star-forming region, from which we obtain direct measurements of mass and radius for these newly formed brown dwarfs. Our mass measurements establish both objects as brown dwarfs, with masses of 0.054 +/- 0.005M(o) and 0.034 +/- 0.003M(o). At the same time, with radii relative to the Sun's of 0.669 +/- 0.034R(o) and 0.511 +/- 0.026R(o), these brown dwarfs are more akin to low-mass stars in size. Such large radii are generally consistent with theoretical predictions for young brown dwarfs in the earliest stages of gravitational contraction. Surprisingly, however, we find that the less-massive brown dwarf is the hotter of the pair; this result is contrary to the predictions of all current theoretical models of coeval brown dwarfs.     

Evolutionary genetics: evolution of mate choice in the wild

Qvarnstr?m et al. test whether the preference of female collared flycatchers (Ficedula albicollis) for males with large forehead patches could have evolved as a by-product of selection acting on male patch size. They find that the crucial genetic correlation between female choice and male patch size is not significant, and conclude that preference for large patches must have been shaped directly by selection. However, their use of the patch size of a female's social partner as a measure of choice is incomplete, and will result in low estimates of the potential for direct selection to shape female preference. Their study is therefore unable to resolve the question of how female preference for large forehead patches has evolved.