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51.
Didier Fraix-Burnet Philippe Choler Emmanuel J.P. Douzery Anne Verhamme 《Journal of Classification》2006,23(1):57-78
This series of papers is intended to evaluate astrocladistics in reconstructing phylogenies of galaxies. The objective of
this second paper is to formalize the concept of galaxy formation and to identify the processes of diversification. We show
that galaxy diversity can be expected to organize itself in a hierarchy. In order to better understand the role of mergers,
we have selected a sample of 43 galaxies from the GALICS database built from simulations with a hybrid model for galaxy formation
studies. These simulated galaxies, described by 119 characters and considered as representing still undefined classes, have
experienced different numbers of merger events during evolution. Our cladistic analysis yields a robust tree that proves the
existence of a hierarchy. Mergers, like interactions (not taken into account in the GALICS simulations), are probably a strong
driver for galaxy diversification. Our result shows that mergers participate in a branching type of evolution, but do not
seem to play the role of an evolutionary clock. 相似文献
52.
Anne R. Dain 《Cellular and molecular life sciences : CMLS》1980,36(12):1358-1360
Summary An account is given of stillborn male twins born to a female Saanen goat (Capra hircus) and a Barbary ram (Ammotragus lervia). The cytogenetics of the cultured hybrid cells are described and attention is drawn to the high proportion of cells which lacked one chromosome.Acknowledgment. I. gratefully acknowledge the help of Mr G.E. Embleton who took the skin biopsy of the Barbary ram. 相似文献
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54.
Lotte Hulliger M. Allgöwer Anne Arcon 《Cellular and molecular life sciences : CMLS》1963,19(11):577-580
Zusammenfassung Monocyten des strömenden Blutes könnenin vitro die morphologischen und funktionellen (Hydroxyprolinbildung) Kriterien von Fibrocyten erwerben. Die quantitative Bedeutung dieses Phänomens für den reparativen Bindegewebsaufbau wurde mit folgender Versuchsanordnung geprüft: Vergleichbare Inokulate von Monocyten (enthalten in der Leucocytenhaut des zentrifugierten Blutes) und von Fibrocyten (aus subcutanem Bindegewebe) von Kaninchen verschiedenen Geschlechts, wurden in Millipore-Kammern eingeschlossen und für 14–21 Tage in das Abdomen eines Kaninchens implantiert. Die Auszählung des Sex-Chromatins in den fibrocytären Kernen am Ende der Züchtungsperiode ergibt, dass ca. 50% monocytären Ursprunges sind. Es wird gefolgert, dass dieses Phänomen bei der eigentlichen Wundheilung noch bedeutungsvoller sein dürfte, da der Zustrom teilungsfähiger Monocyten in einem Wundgebiet kontinuierlich vor sich geht und nicht auf ein initiales Inokulum beschränkt ist. 相似文献
55.
Helene N. Guttman Boris Weinstein Rita M. Bartschot Peter S. Tam 《Cellular and molecular life sciences : CMLS》1975,31(3):285-288
Zusammenfassung Eine Synthese von Scotophobin mit klassischen Methoden ergab ein Produkt, das sich vom natürlichen Peptid hinsichtlich seiner biologischen, chromatographischen und physiologischen Eigenschaften unterschied. Es wird daraus gefolgert, dass die für das natürliche Produkt vorgeschlagene Strukturformel nicht korrekt ist. 相似文献
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59.
A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2 总被引:18,自引:0,他引:18
Loeys BL Chen J Neptune ER Judge DP Podowski M Holm T Meyers J Leitch CC Katsanis N Sharifi N Xu FL Myers LA Spevak PJ Cameron DE De Backer J Hellemans J Chen Y Davis EC Webb CL Kress W Coucke P Rifkin DB De Paepe AM Dietz HC 《Nature genetics》2005,37(3):275-281
We report heterozygous mutations in the genes encoding either type I or type II transforming growth factor beta receptor in ten families with a newly described human phenotype that includes widespread perturbations in cardiovascular, craniofacial, neurocognitive and skeletal development. Despite evidence that receptors derived from selected mutated alleles cannot support TGFbeta signal propagation, cells derived from individuals heterozygous with respect to these mutations did not show altered kinetics of the acute phase response to administered ligand. Furthermore, tissues derived from affected individuals showed increased expression of both collagen and connective tissue growth factor, as well as nuclear enrichment of phosphorylated Smad2, indicative of increased TGFbeta signaling. These data definitively implicate perturbation of TGFbeta signaling in many common human phenotypes, including craniosynostosis, cleft palate, arterial aneurysms, congenital heart disease and mental retardation, and suggest that comprehensive mechanistic insight will require consideration of both primary and compensatory events. 相似文献
60.
Ménétrey J Bahloul A Wells AL Yengo CM Morris CA Sweeney HL Houdusse A 《Nature》2005,435(7043):779-785
Here we solve a 2.4-A structure of a truncated version of the reverse-direction myosin motor, myosin VI, that contains the motor domain and binding sites for two calmodulin molecules. The structure reveals only minor differences in the motor domain from that in plus-end directed myosins, with the exception of two unique inserts. The first is near the nucleotide-binding pocket and alters the rates of nucleotide association and dissociation. The second unique insert forms an integral part of the myosin VI converter domain along with a calmodulin bound to a novel target motif within the insert. This serves to redirect the effective 'lever arm' of myosin VI, which includes a second calmodulin bound to an 'IQ motif', towards the pointed (minus) end of the actin filament. This repositioning largely accounts for the reverse directionality of this class of myosin motors. We propose a model incorporating a kinesin-like uncoupling/docking mechanism to provide a full explanation of the movements of myosin VI. 相似文献