全文获取类型
收费全文 | 120篇 |
免费 | 0篇 |
专业分类
系统科学 | 4篇 |
理论与方法论 | 1篇 |
现状及发展 | 27篇 |
研究方法 | 10篇 |
综合类 | 76篇 |
自然研究 | 2篇 |
出版年
2016年 | 1篇 |
2013年 | 1篇 |
2012年 | 6篇 |
2011年 | 6篇 |
2010年 | 1篇 |
2009年 | 2篇 |
2008年 | 10篇 |
2007年 | 8篇 |
2006年 | 7篇 |
2005年 | 5篇 |
2004年 | 2篇 |
2003年 | 5篇 |
2002年 | 7篇 |
2001年 | 8篇 |
2000年 | 3篇 |
1999年 | 2篇 |
1997年 | 2篇 |
1996年 | 1篇 |
1994年 | 2篇 |
1992年 | 2篇 |
1990年 | 1篇 |
1988年 | 2篇 |
1987年 | 1篇 |
1986年 | 1篇 |
1985年 | 3篇 |
1984年 | 1篇 |
1983年 | 1篇 |
1982年 | 2篇 |
1980年 | 2篇 |
1979年 | 2篇 |
1978年 | 3篇 |
1977年 | 3篇 |
1974年 | 2篇 |
1973年 | 3篇 |
1972年 | 1篇 |
1971年 | 2篇 |
1970年 | 3篇 |
1967年 | 4篇 |
1965年 | 1篇 |
1955年 | 1篇 |
排序方式: 共有120条查询结果,搜索用时 62 毫秒
81.
Mackay TF Richards S Stone EA Barbadilla A Ayroles JF Zhu D Casillas S Han Y Magwire MM Cridland JM Richardson MF Anholt RR Barrón M Bess C Blankenburg KP Carbone MA Castellano D Chaboub L Duncan L Harris Z Javaid M Jayaseelan JC Jhangiani SN Jordan KW Lara F Lawrence F Lee SL Librado P Linheiro RS Lyman RF Mackey AJ Munidasa M Muzny DM Nazareth L Newsham I Perales L Pu LL Qu C Ràmia M Reid JG Rollmann SM Rozas J Saada N Turlapati L Worley KC Wu YQ Yamamoto A Zhu Y Bergman CM Thornton KR 《Nature》2012,482(7384):173-178
A major challenge of biology is understanding the relationship between molecular genetic variation and variation in quantitative traits, including fitness. This relationship determines our ability to predict phenotypes from genotypes and to understand how evolutionary forces shape variation within and between species. Previous efforts to dissect the genotype-phenotype map were based on incomplete genotypic information. Here, we describe the Drosophila melanogaster Genetic Reference Panel (DGRP), a community resource for analysis of population genomics and quantitative traits. The DGRP consists of fully sequenced inbred lines derived from a natural population. Population genomic analyses reveal reduced polymorphism in centromeric autosomal regions and the X chromosome, evidence for positive and negative selection, and rapid evolution of the X chromosome. Many variants in novel genes, most at low frequency, are associated with quantitative traits and explain a large fraction of the phenotypic variance. The DGRP facilitates genotype-phenotype mapping using the power of Drosophila genetics. 相似文献
82.
M. Zacco E. M. Richardson J. O. Crittenden F. C. Dohan J. L. Hollander 《Cellular and molecular life sciences : CMLS》1955,11(7):279-280
Riassunto In pazienti affetti da artrite reumatoide viene iniettato cortisone acetato, idrocortisone acetato, o idrocortisone, nel cavo sinoviale artritico.La durata del riassorbimento di questi 17-idrossicorticoidi; la loro distribuzione nelle cellule e nel fluido articolare e nelle cellule del rivestimento sinoviale; le andamento del processo idrolitico dei composti acetati, studiati con mezzi chimici e cromatografici, si prestano a commenti utili ad interpretare la maggiore efficacia locale dell'idrocortisone.
Supported by a grant from the Helen Augusta Parkhill Foundation.—Communication at the 8th International Congress of Rheumatic Diseases, Geneva, August 1953. 相似文献
Supported by a grant from the Helen Augusta Parkhill Foundation.—Communication at the 8th International Congress of Rheumatic Diseases, Geneva, August 1953. 相似文献
83.
84.
Frequent chromosomal translocations induced by DNA double-strand breaks 总被引:40,自引:0,他引:40
The faithful repair of DNA damage such as chromosomal double-strand breaks (DSBs) is crucial for genomic integrity. Aberrant repair of these lesions can result in chromosomal rearrangements, including translocations, which are associated with numerous tumours. Models predict that some translocations arise from DSB-induced recombination in differentiating lymphoid cell types or from aberrant repair of DNA damage induced by irradiation or other agents; however, a genetic system to study the aetiology of these events has been lacking. Here we use a mouse embryonic stem cell system to examine the role of DNA damage on the formation of translocations. We find that two DSBs, each on different chromosomes, are sufficient to promote frequent reciprocal translocations. The results are in striking contrast with interchromosomal repair of a single DSB in an analogous system in which translocations are not recovered. Thus, while interchromosomal DNA repair does not result in genome instability per se, the presence of two DSBs in a single cell can alter the spectrum of repair products that are recovered. 相似文献
85.
Th. Cooper M. Jellinek Teresa Pinakatt A. W. Richardson 《Cellular and molecular life sciences : CMLS》1965,21(1):28-29
Résumé L'administration intraveineuse de pyridoxine et pyridoxal (10 mg/kg) à des rats anesthésiés inhibe l'augmentation du rendement du cocur. En même temps, une hyperthermie est provoquée par l'irradiation du corps entier avec des ondes de longueur minime (2,450 Mc. c.w. 0.08/w/cm2). Cet effet peut être attribué à l'interaction de ces composés d'amines vasoactifs libérés pendant l'irradiation. 相似文献
86.
87.
DNA methylation and the regulation of gene transcription 总被引:28,自引:0,他引:28
88.
Mutations in IRF6 cause Van der Woude and popliteal pterygium syndromes 总被引:25,自引:0,他引:25
Kondo S Schutte BC Richardson RJ Bjork BC Knight AS Watanabe Y Howard E de Lima RL Daack-Hirsch S Sander A McDonald-McGinn DM Zackai EH Lammer EJ Aylsworth AS Ardinger HH Lidral AC Pober BR Moreno L Arcos-Burgos M Valencia C Houdayer C Bahuau M Moretti-Ferreira D Richieri-Costa A Dixon MJ Murray JC 《Nature genetics》2002,32(2):285-289
89.
A rho-recognition site on phage lambda cro-gene mRNA 总被引:1,自引:0,他引:1
90.
Rotational breakup as the origin of small binary asteroids 总被引:1,自引:0,他引:1
Asteroids with satellites are observed throughout the Solar System, from subkilometre near-Earth asteroid pairs to systems of large and distant bodies in the Kuiper belt. The smallest and closest systems are found among the near-Earth and small inner main-belt asteroids, which typically have rapidly rotating primaries and close secondaries on circular orbits. About 15 per cent of near-Earth and main-belt asteroids with diameters under 10 km have satellites. The mechanism that forms such similar binaries in these two dynamically different populations was hitherto unclear. Here we show that these binaries are created by the slow spinup of a 'rubble pile' asteroid by means of the thermal YORP (Yarkovsky-O'Keefe-Radzievskii-Paddack) effect. We find that mass shed from the equator of a critically spinning body accretes into a satellite if the material is collisionally dissipative and the primary maintains a low equatorial elongation. The satellite forms mostly from material originating near the primary's surface and enters into a close, low-eccentricity orbit. The properties of binaries produced by our model match those currently observed in the small near-Earth and main-belt asteroid populations, including 1999 KW(4) (refs 3, 4). 相似文献