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231.
Comparison of white pock (h) mutants of monkeypox virus with parental monkeypox and with variola-like viruses isolated from animals 总被引:5,自引:0,他引:5
Monkeypox mutants arising spontaneously or after serial, high multiplicity passage were characterized phenotypically and by restriction endonuclease mapping. Some resemble "whitepox" and variola viruses in several of the markers tested but all are distinguishable phenotypically from these. None resembles "whitepox" viruses in genome structure although near-terminal deletions or symmetrical, terminal rearrangements, relative to parental monkeypox, occurred. "Whitepox" viruses isolated from animals closely resemble variola in both phenotype and genome structure. 相似文献
232.
D. Sabourault Françoise Bauché Y. Giudicelli J. Nordmann R. Nordmann 《Cellular and molecular life sciences : CMLS》1981,37(3):227-229
Summary After 3 weeks of continuous ethanol intoxication by inhalation, the maximal number and affinity of the -and -receptors of rat heart were unchanged. These data indicate that adrenergic receptor disturbances are not involved in the mechanism of chronic ethanol-induced triglyceride deposition in the heart.Acknowledgments. This work was supported by grants from the Institut National de la Santé et de la Recherche Médicale. We wish to thank Mr M. Clément for skilled technical assistance in performing chronic ethanol inhalation treatments. 相似文献
233.
Summary In the sandal plant affected by spike disease, caused by mycoplasma-like organisms, the changes occurring in the 5-and 3-nucleotidase activities were studied and their possible significance discussed. 相似文献
234.
R. L. Tyson C. -j. Chang J. L. McLaughlin Y. Aynehchi J. M. Cassady 《Cellular and molecular life sciences : CMLS》1981,37(5):441-442
Summary A novel sesquiterpene lactone, 9--hydroxyparthenolide (1) was isolated from a chloroform extract ofAnvillea garcini that was collected in Iran. The structure of1 was assigned on the basis of high field NMR decoupling experiments and other spectroscopic evidence. This -methylene lactone has shown significant activity in both the 9KB cell culture and P388 mouse leukemia test systems.The authors acknowledge the support of contract No. N01-CM-97296 from the National Cancer Institute and the use of the Purdue University Biochemical Magnetic Resonance Laboratory (NIH grant No. RR01077). This is paper 16 in the series Potential Antitumor Agents. 相似文献
235.
B. Lejczak H. Starzemska P. Mastalerz 《Cellular and molecular life sciences : CMLS》1981,37(5):461-462
Summary Analogues of glutamic acid, -methylglutamic acid and glutamine in which the -or -COOH groups are replaced by PO3H2 or P(O)(OH3)OH functions competitively inhibit rat liver glutamine synthetase. The K1 values are comparable to or lower than KM for L-glutamate.This study was supported by grant R.1.9. 相似文献
236.
R. Lenzhofer C. Cerni I. Fröhlich J. Prager H. Pointner 《Cellular and molecular life sciences : CMLS》1981,37(9):1015-1017
Summary The influence of somatostatin on tumor cell growth was studied in vivo in mice (sarcoma 180 ascites tumor and Lewis lung tumor) and in vitro on nontransformed and polyoma-transformed cell lines. 4 or 20 g/100 g of cyclic somatostatin and 4 g/100 g of linear protamin Zn-bound somatostatin were injected s.c. twice daily in the in vivo study. Cyclic somatostatin (1, 4 or 10 g/ml) was added twice daily to the cell cultures. Somatostatin administration influenced neither the survival of animals nor the growth rate of cultured cell lines. *** DIRECT SUPPORT *** A2025117 00011 相似文献
237.
238.
Summary There are wide individual variations in the thermal stability of human plasma dopamine--hydroxylase (DBH). Thermal stability variations have proven of value in biochemical genetic studies of many enzymes. The development of DBH thermolability depends on the exposure of plasma to oxygen. This observation may help to elucidate the biochemical basis of the genetic regulation of DBH.This work was supported in part by NIH grants HL 17487 and NS 11014. 相似文献
239.
Summary Subdermal injections of PGE2 (5 g) in the rat foot lead to increases in the potentials evoked in sensory nerve branches by the mechanical stimulation of the skin. This sensitization of both A and C fibres complements the previously described hyperalgesic effects of prostaglandins of the E series. 相似文献
240.
F. Bonneaux P. Labrude E. Dellacherie 《Cellular and molecular life sciences : CMLS》1981,37(8):884-886
Summary Stroma-free hemoglobin solutions present some drawbacks when used as blood substitutes, essentially because the hemoprotein has a low vascular retention, due to its small hydrodynamic volume. Covalent coupling of the protein with dextran derivatives artificially increases its size and affords polymeric conjugates whose oxygen-binding properties (Barcroft's curve, Hill coefficient) depend on the molecular weight.The authors wish to thank Prof. J. Neel and Prof. C. Vigneron for useful discussions and criticism. 相似文献