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131.
AIDS virus-specific cytotoxic T lymphocytes in lung disorders 总被引:6,自引:0,他引:6
F Plata B Autran L P Martins S Wain-Hobson M Rapha?l C Mayaud M Denis J M Guillon P Debré 《Nature》1987,328(6128):348-351
Human immunodeficiency virus (HIV) is implicated in the development of AIDS (acquired immune deficiency syndrome). HIV infection leads to the generation of HIV-specific thymus-derived (T) lymphocytes in humans and apes. We describe an experimental system permitting the quantitative and systematic analysis of HIV-specific cytotoxic T lymphocytes (CTL). Functional, HIV-specific CTL are obtained by broncho-alveolar lavage (BAL) from the lungs of seropositive patients with lymphocytic alveolitis. These alveolar CTL: (1) recognize and kill HIV-infected alveolar macrophages in vitro under autologous, but not heterologous, conditions; (2) correspond to standard CTL as they express the CD3 and CD8 surface markers, but not the CD4 marker; and (3) are restricted by class I HLA transplantation antigens in their cytotoxic activities. We propose the hypothesis that interactions between HIV-specific CTL and infected macrophages induce major inflammatory reactions in seropositive patients. 相似文献
132.
133.
Jian?Zhang Sumin?Li Yongqiang?Tian Yunge?Zhao Amy?Sang?Qing-Xiang Enkui?DuanEmail author 《科学通报(英文版)》2002,47(22):1884-1888
Matrix metalloproteinase-26 (MMP-26, endometase and matrilysin-2), a novel member of the MMPs family, is detected not only
in the placenta and uterus, but is widely expressed in malignant tumors from different sources as well as in diverse tumor
cell lines. However, the function of MMP-26 in the reproductive system has never been reported. Expression of MMP-26 in mouse
embryos and the function of the MMP-26 antibody during mouse embryo implantation was examined for the first time by injecting
the uterine horn, immunohistochemistry,in situ hybridization, co-culture of mouse blastocysts and uterine monolayer epithelial cells, Western blot, RT-PCR, Northern blot
and zymography. Our results show that there is strong expression of MMP-26 mRNA and protein in the mouse embryo. Furthermore,
the MMP-26 antibody dramatically inhibited mouse embryo implantation and significantly inhibited adhesion and outgrowth of
mouse blastocysts onin vitro uterine monolayer epithelial cells. At the same time, the MMP-26 antibody inhibited the expression of integrin αV mRNA and
protein in a dose-dependent manner. These data suggest that MMP-26 may play a role in some of the tissue-remodeling events
associated with the invasion of the endometrium by trophoblast cells and facilitate successfully embryo implantation. 相似文献
134.
Cunyue?Guo Zhi?Ma Mingge?Zhang Aihua?He Yucai?Ke Youliang?HuEmail author 《科学通报(英文版)》2002,47(15):1267-1270
The catalyst [(2-ArN=C(Me))2C5H3N]FeCl2 (Ar = 2-C6H4(i-Pr)) with methylaluminoxane (MAO) as cocatalyst was intercalated between layers of montmorillonite (MMT) for ethylene oligomerization.
Metallocene catalyst Me2Si(Ind)2ZrCl2 and MAO was then added to form a dual functional catalytic system. A PE/MMT nanocomposite was prepared by copolymerization
of ethylene with α-olefins produced in situ from ethylene over the dual functional catalytic system. The catalytic system was of high polymeric activity. The resultant
PE/MMT nanocomposites were stable and got increases in tensile strength and temperature of maximum weight loss (Tonset). 相似文献
135.
Radiolarian record to paleoecological environment change events over the past 1.2 MaBP in the southern South China Sea 总被引:2,自引:0,他引:2
This note studies the Radiolarian fossil groups since 1.2 MaBP in ODP leg 184 site 1143, the southern South China Sea (SCS).
The result shows that radiolarian abundance experienced a significant variation: before 0.9 MaBP it remained at the extremely
low level, but increased with low extent between 0.9–0.65 Ma, which corresponded to the Mid-Pleistocene Transition stage,
and it increased rapidly after 0.65 MaBP. During the whole process, the average abundance became higher and higher in each
stage, and showed regularly periodic fluctuations. The obvious increase after 0.65 MaBP is inferred to result from the enhanced
upwelling in this region, which was induced by the intensified monsoon circulation after the “Mid-Pleistocene Transition”.
An outstanding result of the spectral analyses is that a long oscillation of ∼ 0.2 Ma cycle was found in the records of radiolarian
abundance and complex diversity, which corresponds well to the result of other paleoceanographic indexes. This probably indicated
a special cycle characteristic of paleoecological environment evolution in this area. In addition, all of the radiolarian
indexes show an obvious boundary in about 0.47 MaBP, indicating the abrupt variation of the community structure and radiolarian
abundance level before and after 0.47 MaBP. So we suppose that there existed a distinct change event of oceanic ecology environment
during that period. 相似文献
136.
The intron is an important component of eukaryotic gene. Extensive studies have been conducted to get a better understanding
of its structure and function. This paper presents a brief review of the structure and function of introns in higher plant
genes. It is shown that higher plant introns possess structural properties shared by all eukaryotic introns, however, they
also exhibit a striking degree of diversity. The process of intron splicing in higher plant genes involves interaction between
multiple cis-acting elements and trans-acting factors, such as 5′ splicing site, 3′ splicing site and many protein factors. The process of intron splicing is an
important level at which gene expression is regulated. Especially alternative splicing of intron can regulate time and space
of gene expression. In addition, some introns in higher plant genes also regulate gene expression by affecting the pattern
of gene expression, enhancing the level of gene expression and driving the gene expression. 相似文献
137.
Considering the features of martensitic transformation in Fe-Mn-Si based alloys, the Landau theory is established by introducing the density of stacking faults as a new order parameter ηand the corresponding free energy function. By using such an order parameter, the stacking fault mechanism of the nucleation and growth for the γ(fcc)→ε(hcp) martensitic transformation can be reasonably explained, and a further detailed mechanism is proposed. The stacking faults are generated and overlapped in an irregular form at the beginning and then becoming regular to create some transition structures till a stable phase forms at a certain temperature. The importance of the interface soliton is to complete the transformations into various structures of martensite but not the twinned one. The thermodynamics of fcc→hcp transformation and those between different transition structures are described by the free energy function established in the present note. 相似文献
138.
Based on 489 known perovskite-type complex oxides and a number of other type complex oxides, the pattern recognition-atomic parameter method is adopted to find regularities of the formation and the lattice distortion of the perovskite structure. It has been found that the restriction on Goldschmidt's t factor constitutes only a necessary but not a sufficient condition to form perovskite-type compounds. A more effective mathematical model, which can precisely sum up the regularities of the formation, the lattice distortion,and the cell constants of known perovskite-type compounds and reliably make corresponding predictions on unknown compounds, can be set up by integrating multiple atomic parameters such as ionic radii, ionic valency, and Basanov's electronegativity of constituent elements. Based on it, an intelligent database has been implemented. Its prediction accuracy is tested by eight newly discovered perovskite-type compounds such as Eu(Mn0.5 Ni0.5)O3, etc. (they are not included in the database during the test). The prediction resuits are in agreement with experimental facts. 相似文献
139.
The microscopic structure of charcoals was determined in two sites of Bronze Age, Chifeng area by using the scanning electronic
microscope. The results showed that these charcoals are all timbers of Mongolian oak (Quercus mongolica). It has powerful climatic indicative significance. Based on the assemblage of pollen composition, their eco-climatic index
and character of community, the vegetation reconstruction of Bronze Age was obtained. The reconstruction showed that the zonal
vegetation was Mongolian oak forest and Chinese pine forest in the loess hills in the Chifeng area, which suggested that the
climatic condition was warmer and wetter at that time than present time. 相似文献
140.
Chengzhi?LiuEmail author You?Zhao Cunbo?Fan Douxing?Cui Xingwei?Han Fumin?Yang 《科学通报(英文版)》2002,47(13):1070-1072
This note introduces the performance and observation summary of the SLR system at Changcun Observatory, the Chinese Academy
of Sciences. The performance of the SLR system has been greatly improved since August 1997. The single shot precision is improved
from 5–7 cm to 1–2 cm and the normal point precision reaches 4–7 mm. The long-term stability is better than 1 cm. The amount
of observation has been increased from 1000 to over 3000 passes. The whole performance of Changcun SLR system has reached
the advanced level among the worldwide SLR stations. 相似文献