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151.
Evolutionary developmental biology has encouraged a change of research emphasis from the sorting of phenotypic variation by natural selection to the production of that variation through development. Some morphologies are more readily generated than others, and developmental mechanisms can limit or channel evolutionary change. Such biases determine how readily populations are able to respond to selection, and have been postulated to explain stasis in morphological evolution and unexplored morphologies. There has been much discussion about evolutionary constraints but empirical data testing them directly are sparse. The spectacular diversity in butterfly wing patterns is suggestive of how little constrained morphological evolution can be. However, for wing patterns involving serial repeats of the same element, developmental properties suggest that some directions of evolutionary change might be restricted. Here we show that despite the developmental coupling between different eyespots in the butterfly Bicyclus anynana, there is great potential for independent changes. This flexibility is consistent with the diversity of wing patterns across species and argues for a dominant role of natural selection, rather than internal constraints, in shaping existing variation. 相似文献
152.
Hole DG Whittingham MJ Bradbury RB Anderson GQ Lee PL Wilson JD Krebs JR 《Nature》2002,418(6901):931-932
House-sparrow populations have declined sharply in Western Europe in recent decades, but the reasons for this decline have yet to be identified, despite intense public interest in the matter. Here we use a combination of field experimentation, genetic analysis and demographic data to show that a reduction in winter food supply caused by agricultural intensification is probably the principal explanation for the widespread local extinctions of rural house-sparrow populations in southern England. We show that farmland populations exhibit fine-level genetic structuring and that some populations are unable to sustain themselves (sinks), whereas others act as sources. 相似文献
153.
Detection of large-scale variation in the human genome 总被引:26,自引:0,他引:26
Iafrate AJ Feuk L Rivera MN Listewnik ML Donahoe PK Qi Y Scherer SW Lee C 《Nature genetics》2004,36(9):949-951
We identified 255 loci across the human genome that contain genomic imbalances among unrelated individuals. Twenty-four variants are present in > 10% of the individuals that we examined. Half of these regions overlap with genes, and many coincide with segmental duplications or gaps in the human genome assembly. This previously unappreciated heterogeneity may underlie certain human phenotypic variation and susceptibility to disease and argues for a more dynamic human genome structure. 相似文献
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156.
Mutations in SOX2 cause anophthalmia 总被引:12,自引:0,他引:12
Fantes J Ragge NK Lynch SA McGill NI Collin JR Howard-Peebles PN Hayward C Vivian AJ Williamson K van Heyningen V FitzPatrick DR 《Nature genetics》2003,33(4):461-463
A submicroscopic deletion containing SOX2 was identified at the 3q breakpoint in a child with t(3;11)(q26.3;p11.2) associated with bilateral anophthalmia. Subsequent SOX2 mutation analysis identified de novo truncating mutations of SOX2 in 4 of 35 (11%) individuals with anophthalmia. Both eyes were affected in all cases with an identified mutation. 相似文献
157.
Vanhamme L Paturiaux-Hanocq F Poelvoorde P Nolan DP Lins L Van Den Abbeele J Pays A Tebabi P Van Xong H Jacquet A Moguilevsky N Dieu M Kane JP De Baetselier P Brasseur R Pays E 《Nature》2003,422(6927):83-87
Human sleeping sickness in east Africa is caused by the parasite Trypanosoma brucei rhodesiense. The basis of this pathology is the resistance of these parasites to lysis by normal human serum (NHS). Resistance to NHS is conferred by a gene that encodes a truncated form of the variant surface glycoprotein termed serum resistance associated protein (SRA). We show that SRA is a lysosomal protein, and that the amino-terminal alpha-helix of SRA is responsible for resistance to NHS. This domain interacts strongly with a carboxy-terminal alpha-helix of the human-specific serum protein apolipoprotein L-I (apoL-I). Depleting NHS of apoL-I, by incubation with SRA or anti-apoL-I, led to the complete loss of trypanolytic activity. Addition of native or recombinant apoL-I either to apoL-I-depleted NHS or to fetal calf serum induced lysis of NHS-sensitive, but not NHS-resistant, trypanosomes. Confocal microscopy demonstrated that apoL-I is taken up through the endocytic pathway into the lysosome. We propose that apoL-I is the trypanosome lytic factor of NHS, and that SRA confers resistance to lysis by interaction with apoL-I in the lysosome. 相似文献
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159.
Patricia Fara 《Studies in history and philosophy of science》1997,28(1):187-195
160.
Résumé Le régime de contrôle (alimentation de laboratoire des lapins) deMicrotus montanus a été augmenté de plantes vertes. La glande pinéale des animaux recevant le supplément eut un poids inférieur à celui de la glande des témoins (p<0,01).
This project was supported by the Atomic Energy Commission, contract No. AT-(40-1)-3946, the United States Public Health Service No. NIH-GM 00669-MBS and a Biomedical Sciences Support Grant from Tulane University. 相似文献
This project was supported by the Atomic Energy Commission, contract No. AT-(40-1)-3946, the United States Public Health Service No. NIH-GM 00669-MBS and a Biomedical Sciences Support Grant from Tulane University. 相似文献