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51.
Lindström S Vachon CM Li J Varghese J Thompson D Warren R Brown J Leyland J Audley T Wareham NJ Loos RJ Paterson AD Rommens J Waggott D Martin LJ Scott CG Pankratz VS Hankinson SE Hazra A Hunter DJ Hopper JL Southey MC Chanock SJ Silva Idos S Liu J Eriksson L Couch FJ Stone J Apicella C Czene K Kraft P Hall P Easton DF Boyd NF Tamimi RM 《Nature genetics》2011,43(3):185-187
High-percent mammographic density adjusted for age and body mass index is one of the strongest risk factors for breast cancer. We conducted a meta analysis of five genome-wide association studies of percent mammographic density and report an association with rs10995190 in ZNF365 (combined P = 9.6 × 10(-10)). Common variants in ZNF365 have also recently been associated with susceptibility to breast cancer. 相似文献
52.
Electrical properties of wet collagen 总被引:10,自引:0,他引:10
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N. E. Eriksson N. V. B. Marsden D. Z. Popov 《Cellular and molecular life sciences : CMLS》1974,30(5):572-574
Zusammenfassung In gefriergetrockneten Schnitten von Sephadex G-25 wurde die Verteilung einiger Alkalihalogenverbindungen mit Hilfe ihrer Röntgenstrahlenfluoreszenz im Raster-Elektronenmikroskop untersucht. Es ergab sich eine ionisch homogene radiale Verteilung und fluoreszierende Makromoleküle (Dextran) wurden von den Gelschichten ausgeschieden.
We wish to thank Pharmacia, Uppsala, for very kindly giving the fluorescent dextran and Sephadex® G-25. We also want to thank DrL. O. Lindbom for informative discussions and acknowledge financial support from the Swedish Natural Science Research Council, Grant No 2944. 相似文献
We wish to thank Pharmacia, Uppsala, for very kindly giving the fluorescent dextran and Sephadex® G-25. We also want to thank DrL. O. Lindbom for informative discussions and acknowledge financial support from the Swedish Natural Science Research Council, Grant No 2944. 相似文献
54.
Andresen GB Ashkezari MD Baquero-Ruiz M Bertsche W Bowe PD Butler E Cesar CL Chapman S Charlton M Deller A Eriksson S Fajans J Friesen T Fujiwara MC Gill DR Gutierrez A Hangst JS Hardy WN Hayden ME Humphries AJ Hydomako R Jenkins MJ Jonsell S Jørgensen LV Kurchaninov L Madsen N Menary S Nolan P Olchanski K Olin A Povilus A Pusa P Robicheaux F Sarid E el Nasr SS Silveira DM So C Storey JW Thompson RI van der Werf DP Wurtele JS Yamazaki Y 《Nature》2010,468(7324):673-676
Antimatter was first predicted in 1931, by Dirac. Work with high-energy antiparticles is now commonplace, and anti-electrons are used regularly in the medical technique of positron emission tomography scanning. Antihydrogen, the bound state of an antiproton and a positron, has been produced at low energies at CERN (the European Organization for Nuclear Research) since 2002. Antihydrogen is of interest for use in a precision test of nature's fundamental symmetries. The charge conjugation/parity/time reversal (CPT) theorem, a crucial part of the foundation of the standard model of elementary particles and interactions, demands that hydrogen and antihydrogen have the same spectrum. Given the current experimental precision of measurements on the hydrogen atom (about two parts in 10(14) for the frequency of the 1s-to-2s transition), subjecting antihydrogen to rigorous spectroscopic examination would constitute a compelling, model-independent test of CPT. Antihydrogen could also be used to study the gravitational behaviour of antimatter. However, so far experiments have produced antihydrogen that is not confined, precluding detailed study of its structure. Here we demonstrate trapping of antihydrogen atoms. From the interaction of about 10(7) antiprotons and 7?×?10(8) positrons, we observed 38 annihilation events consistent with the controlled release of trapped antihydrogen from our magnetic trap; the measured background is 1.4?±?1.4 events. This result opens the door to precision measurements on anti-atoms, which can soon be subjected to the same techniques as developed for hydrogen. 相似文献
55.
Positional identification of TNFSF4, encoding OX40 ligand, as a gene that influences atherosclerosis susceptibility 总被引:25,自引:0,他引:25
Wang X Ria M Kelmenson PM Eriksson P Higgins DC Samnegård A Petros C Rollins J Bennet AM Wiman B de Faire U Wennberg C Olsson PG Ishii N Sugamura K Hamsten A Forsman-Semb K Lagercrantz J Paigen B 《Nature genetics》2005,37(4):365-372
Ath1 is a quantitative trait locus on mouse chromosome 1 that renders C57BL/6 mice susceptible and C3H/He mice resistant to diet-induced atherosclerosis. The quantitative trait locus region encompasses 11 known genes, including Tnfsf4 (also called Ox40l or Cd134l), which encodes OX40 ligand. Here we report that mice with targeted mutations of Tnfsf4 had significantly (P 相似文献
56.
57.
Piezoelectric properties of dry and wet bone 总被引:2,自引:0,他引:2
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Moore RB Oborník M Janouskovec J Chrudimský T Vancová M Green DH Wright SW Davies NW Bolch CJ Heimann K Slapeta J Hoegh-Guldberg O Logsdon JM Carter DA 《Nature》2008,451(7181):959-963
Many parasitic Apicomplexa, such as Plasmodium falciparum, contain an unpigmented chloroplast remnant termed the apicoplast, which is a target for malaria treatment. However, no close relative of apicomplexans with a functional photosynthetic plastid has yet been described. Here we describe a newly cultured organism that has ultrastructural features typical for alveolates, is phylogenetically related to apicomplexans, and contains a photosynthetic plastid. The plastid is surrounded by four membranes, is pigmented by chlorophyll a, and uses the codon UGA to encode tryptophan in the psbA gene. This genetic feature has been found only in coccidian apicoplasts and various mitochondria. The UGA-Trp codon and phylogenies of plastid and nuclear ribosomal RNA genes indicate that the organism is the closest known photosynthetic relative to apicomplexan parasites and that its plastid shares an origin with the apicoplasts. The discovery of this organism provides a powerful model with which to study the evolution of parasitism in Apicomplexa. 相似文献