中祁连地块东段元古宙基底湟源群沉积构造环境

通过对中祁连地块东段元古宙基底湟源群原岩建造及其地球化学特征的研究,认为：湟源群主要由各种千枚岩、片岩、变粒岩、大理岩、石英岩和斜长角闪岩等组成的中浅变质的表壳岩组合;其原岩为一套由陆源碎屑岩、不纯碳酸盐岩、中基性大山岩等组成的火山岩沉积岩组合;湟源群中变质沉积岩系中沉积韵律、沉积条带构造的广泛发育以及浊积层的存在等,指示了其原岩建造具有复理石或类复理石建造的特征;其中变质杂砂岩的地球化学特征类似于大陆岛弧或安底斯岛弧型杂砂岩的特征;湟源群变质中基性火山岩的地球化学特征类似于岛弧或活动大陆边缘的钙碱性火山岩的特征。经综合分析得出,湟源群沉积构造环境可能为陆缘弧后盆地且靠近大陆一侧。     

基于WWW信息系统的连接技术及其一种实现

对两层客户机／服务器（ｃｌｉｅｎｔ／ｓｅｒｖｅｒ）结构与客户机／服务器／服务器３ 层体系结构进行了比较和分析,讨论了目前采用 Ｗ Ｗ Ｗ 技术的信息系统的一些常用连接技术,重点阐述了 Ｃｏｌｄ Ｆｕｓｉｏｎ这样一种简捷、高效的连接技术,并用 Ｃｏｌｄ Ｆｕｓｉｏｎ 实现了一个 Ｗ Ｗ Ｗ 上的应用系统     

Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease.

Huntington's disease is an autosomal-dominant progressive neurodegenerative disorder resulting in specific neuronal loss and dysfunction in the striatum and cortex. The disease is universally fatal, with a mean survival following onset of 15-20 years and, at present, there is no effective treatment. The mutation in patients with Huntington's disease is an expanded CAG/polyglutamine repeat in huntingtin, a protein of unknown function with a relative molecular mass of 350,000 (M(r) 350K). The length of the CAG/polyglutamine repeat is inversely correlated with the age of disease onset. The molecular pathways mediating the neuropathology of Huntington's disease are poorly understood. Transgenic mice expressing exon 1 of the human huntingtin gene with an expanded CAG/polyglutamine repeat develop a progressive syndrome with many of the characteristics of human Huntington's disease. Here we demonstrate evidence of caspase-1 activation in the brains of mice and humans with the disease. In this transgenic mouse model of Huntington's disease, expression of a dominant-negative caspase-1 mutant extends survival and delays the appearance of neuronal inclusions, neurotransmitter receptor alterations and onset of symptoms, indicating that caspase-1 is important in the pathogenesis of the disease. In addition, we demonstrate that intracerebroventricular administration of a caspase inhibitor delays disease progression and mortality in the mouse model of Huntington's disease.     

Pr2Fe17-xSix合金的磁热效应

用电弧熔炼法制备了Pr2Fe17-xSix(x=0,0.1,0.15,0.3)系列合金,用粉末X线衍射和磁性测量研究样品的结构、磁性、磁熵变及绝热温变.结果表明:Pr2Fe17-xSix系列合金的晶体结构为Th2Zn17型菱方结构;随着Si含量的增加,居里温度由x=0时的290K提高到x=0.3时的328K;外加磁场为1.5T时,磁熵变由x=0时的2.39J/(kg.K)降低到x=0.3时的1.67J/(kg.K),但绝热温变没有显著变化.     

Severe accident risks from external events

This paper reviews the early development of design requirements for seismic events in US early developing US nuclear electric generating fleet. Notable safety studies, including WASH-1400, Sandia Siting Study, and the NUREG-1150 probabilistic risk study are briefly reviewed in terms of their relevance to extreme accidents arising from seismic and other severe accident initiators. Specific characteristic about the nature of severe accidents in nuclear power plants are reviewed along with present day state of art analysis methodologies (MELCOR and MACCS) that are used to evaluate severe accidents and to optimize mitigative and protective actions against such accidents. I is the aim of this paper to make nuclear operating nations aware of the risks that accompany a much needed energy resource and to identify some of the tools, techniques and landmark safety studies that serve to make the technology more safe and to maintain vigilance and adequate safety culture for the responsible management of this valuable but unforgiving technology.     

Late Paleozoic magmatism in South China:Oceanic subduction or intracontinental orogeny?

A gneissic granite with an U-Pb age of 313±4 Ma was found in northeastern Fujian Province,South China.It is an S-type granite characterized by high K2O,Al2O3 and low SiO2,Na2O contents with high A/CNK ratio of 1.22 for the whole rock.Zircons with stubby morphology from the gneissic granite yield 206 Pb/238 U ages ranging from 326 to 301 Ma with a weighted average age of 313±4 Ma,and negative εHf(t) values from -8.35 to -1.74 with Hf model ages (TCDM) of 1.43 to 1.84 Ga.This S-type granite probably originated from late Paleoproterozoic crust in intracontinental orogeny.Integrated with previous results on paleogeographic reconstruction of South China,the nature of Paleozoic basins,Early Permian volcanism and U-Pb-Hf isotope of detrital zircons from the late Paleozoic to early Mesozoic sedimentary rocks,we suggest the occurrence of a late Paleozoic orogeny in the eastern Cathaysia Block,South China.This orogenic cycle includes Late Carboniferous (340-310 Ma) orogeny (compression) episode and Early Permian (287-270 Ma) post-orogenic or intraplate extension episode.Therefore,the late Paleozoic magmatism in the southeastern South China probably occurred during the intraplate orogeny rather than the arc-related process.     

Grenvillian orogeny in the Southern Cathaysia Block: Constraints from U-Pb ages and Lu-Hf isotopes in zircon from metamorphic basement

Metamorphic basement rocks in the Cathaysia Block are composed mainly of meta-sediments with different ages. New zircon U-Pb geochronological results from the meta-sedimentary rocks exposed in the Zengcheng and Hezi areas, southern Cathaysia Block, show that they consist dominantly of early Neoproterozoic （1.0-0.9 Ga） materials with minor Paleo- to Mesoproterozoic and late Neoproterozoic （0.8-0.6 Ga） components, suggesting that the detritus mostly come from a Grenvillian orogen. The youngest detrital zircon ages place a constraint on the deposition time of these sediments in Late Neoproterozoic. Zircon Hf isotopic compositions indicate that the Grenvillian zircons were derived from the reworking of Mesoproterozoic arc magmatic rocks and Paleoproterozoic continental crust, implying an arc-continent collisional setting. Single-peak age spectra and the presence of abundant euhedral Grenvillian zircons suggest that the sedimentary provenance is not far away from the sample location. Thus, the Grenvillian orogen probably preexisted along the southern margin of the Cathaysia Block, or very close to the south. Similarity in the ages of Grenvillian orogeny and the influence of the assembly of Gondwana in South China with India and East Antarctic are discussed, with suggestion that South China was more likely linked with the India-East Antarctica continents in Early Neoproterozoic rather than between western Laurentia and eastern Australia.     

北京专利技术转移状况分析及建议

对2001－2006年北京专利技术转移情况所做的分析表明,北京专利技术转移呈现良好的增长势头,
专利技术合同成交额年均增长达到90.09%,其中发明专利达到85.93%,反映出北京技术创新能力和水平在
不断提升,知识产权保护意识明显增强。制定专利保护和应用战略、加大有利于专利技术转移的鼓励政策力
度、建立“产学研”互动机制等措施,将进一步推动北京地区专利技术的转移和转化,并朝着专利技术产业
化方向发展。     

Positive feedback sharpens the anaphase switch

At the onset of anaphase, sister-chromatid cohesion is dissolved abruptly and irreversibly, ensuring that all chromosome pairs disjoin almost simultaneously. The regulatory mechanisms that generate this switch-like behaviour are unclear. Anaphase is initiated when a ubiquitin ligase, the anaphase-promoting complex (APC), triggers the destruction of securin, thereby allowing separase, a protease, to disrupt sister-chromatid cohesion. Here we demonstrate that the cyclin-dependent kinase 1 (Cdk1)-dependent phosphorylation of securin near its destruction-box motif inhibits securin ubiquitination by the APC. The phosphatase Cdc14 reverses securin phosphorylation, thereby increasing the rate of securin ubiquitination. Because separase is known to activate Cdc14 (refs 5 and 6), our results support the existence of a positive feedback loop that increases the abruptness of anaphase. Consistent with this model, we show that mutations that disrupt securin phosphoregulation decrease the synchrony of chromosome segregation. Our results also suggest that coupling securin degradation with changes in Cdk1 and Cdc14 activities helps coordinate the initiation of sister-chromatid separation with changes in spindle dynamics.