Prospective epidemiologic studies and the nature of the association between Epstein-Barr virus (EBV) and Burkitt's lymphoma (BL)]

The prospective study carried out by the International Agency for Research on Cancer on the relationships between E.B.V. infection and Burkitt's Lymphoma development as well as their partial malaria chemoprophylaxy proposals, are discussed as an example of studying the role of a virus and of co-factors in one human cancer.     

Production and characterization of antibody against aflatoxin M1

Antibody against aflatoxin M1 was obtained after immunization of rabbits with bovine serum albumin-afla M1 oxime conjugate. The antibody has greatest binding efficiency for afla M1, and was less efficient for afla B1. Cross-reaction of antibody with aflatoxin Q1, aflatoxicol, and aflatoxin B2a was weak. Aflatoxin B2, G1, and G2 and afla B1-guanine adducts showed almost no cross-reaction with the antibody. The sensitivity of the binding assay for aflatoxin M1 detection is in the range of 1-10 ng per assay. Detailed methods for the preparation of the conjugate, production of immune serum, and methods for antibody determination are described.     

Transmembrane secretory potentials in the cat submandibular gland during perfusion with potassium-free and low sodium Locke solutions

Zusammenfassung Während der Perfusion der Submandibulardrüse der Katze mit kaliumfreier Lockelösung oder mit einer Lockelösung, in der das meiste Kochsalz durch Tetraethylammoniumchlorid ersetzt wurde, sind die sekretorischen Potentialdifferenzen der basalen Azinuszellmembran vergrössert. Ein Kaliumstrom aus der Azinuszelle, der teilweise von einem Natriumstrom in die Zelle kurzgeschlossen wird, könnte die sekretorischen Potentialdifferenzen erklären.

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With the technical assistance of G.Pedersen.     

Leão's spreading depression in the cerebellum of rat

Zusammenfassung Ischämie ruft in der Kleinhirnrinde eine ähnliche Depolarisation hervor wie in der Grosshirnrinde. Durch lokale KCl-Applikation erhält man in der Kleinhirnrinde langsame Potentialwellen, die in Amplitude und Ausbreitungsgeschwindigkeit der «spreading depression» vonLeão in der Grosshirnrinde entsprechen. Ischämie und lokale Applikation von 2,4-Dinitrophenol bewirken in beiden Rindengebieten gleiche Verschiebungen der Kaliumionen.