S → N acetyl migration in yeast glyceraldehyde-3-phosphate dehydrogenase

Zusammenfassung Nachweis, dass bei der Hefe-GAPD-katalysierten PNPA-Hydrolyse das als Zwischenprodukt gebildete S-Acetyl-Enzym durch eine intramolekulare Wanderung zu einem N-Acetyl-Derivat führen kann. Im Gegensatz zu dem aus Muskel isolierten Enzym findet im Hefe-Enzym eine Acetylwanderung bzw. eine Acetylierung des gegebenen Lysin statt, ohne wesentliche Beeinflussung durch das Coenzym (NAD).     

Vestibular origin of the rapid eye movements during desynchronized sleep

Riassunto I movimenti rapidi oculari caratteristici del sonno desincronizzato nel gatto dipendono dall'integrità anatomica e funzionale dei nuclei vestibolari.

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This investigation was supported by PHS research grant NB-02990-04 from the National Institute of Neurological Diseases and Blindness, N.I.H., Public Health Service (USA).     

Histochemische Untersuchungen zur Natur der Cytoplasma-Einschlüsse des Lungentumors der Maus

Résumé Dans une étude histochimique on a montré que les inclusions cytoplasmiques des tumeurs pulmonaires de la souris (Klärner etGieseking) contenaient une polysaccharide neutre jointe à l'acide ribonucléique. Les résultats ont été discutés au sens d'une hypothèse virale.     

Hydroxyproline production in chick fibroblast cultures

Zusammenfassung Kulturen von Hühnerherzfibroblasten wurden nach 10, 21 und 28 Tagenin vitro auf ihren Gehaltan Hydroxyprolin — einer wichtigen Aminosäure des Kollagens — untersucht. Nach 10, bzw. 21 Tagen ist eine signifikante, durch Prolinzugaben nicht beeinflussbare Vermehrung des zu 50% löslichen Hydroxyprolins feststellbar.

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Kantonsspital, Chur.     

Concentrations of organic acids in animal tissues

Résumé Les auteurs ont réuni en 2 tableaux les données de la littérature sur le degré de concentration des acides organiques dans les tissus animaux.

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Supported in part by a research grant from the National Cancer Institute, National Institutes of Health, U. S. Public Health Service.     

On the importance of thiols and disulphides and the antiviral action of dichloropyrimidines

Summary Free SH or SS groups of infected cells are not involved in the antiviral action of dichloropyrimidines.This work has been supported by a grant of the Consiglio Nazionale delle Ricerche, Roma (Italy).     

T3-Ti receptor triggering of T8+ suppressor T cells leads to unresponsiveness to interleukin-2

T3-associated disulphide linked heterodimers (Tin) comprised of clonally unique alpha-chains of molecular weight (MW) 49,000-54,000 and beta chains of MW 43,000 have been identified as the antigen receptors on human cytotoxic effector and inducer T-lymphocytes. Crosslinking of Ti molecules by either the appropriate nominal antigen/MHC specificity or anti-clonotypic monoclonal antibody results in clonal expansion of such cells via induction of IL-2 receptor expression, endogenous IL-2 release and IL-2-IL-2 receptor interaction. To determine whether analogous antigen receptor molecules and autocrine growth mechanisms are utilized by suppressor T-cells, we produced an anti-clonotypic monoclonal antibody against a non-cytotoxic T8+ suppressor T-cell, T8AC6, which defines a T3-associated disulphide-linked heterodimer of similar molecular weight to the above clonotypes. We find that Te-Ti triggering of suppressor clones (T8AC6, T8AC7 or T8RW) does not result in IL-2 production or T-cell proliferation and in contrast to inducer clones, also leads to a transient IL-2 unresponsive state. We suggest that such T3-Ti receptor mediated autoregulation of suppressor T-cell growth is necessary in the facilitation of initial inducer T-cell activation following antigenic perturbation.     

The effect of indole derivatives onMycobacterium tuberculosis

Résumé L'étude des effets de l'indole sur l'organismeM. tuberculosis hominis révéla qu'il est bactériostatiquein vitro etin vivo chez les cobayes infectés par lui (5 mg par jour pendant 15 jours). Les acides indol-acétiques et indolpropioniques sont aussi légèrement tuberculostatiques.