Structure of an antibody combining site by magnetic resonance.

The structure of the combining site of the DNP binding IgA mouse myeloma protein MOPC 315 has been determined by a combination of high resolution nuclear magnetic resonance, electron spin resonance, model building and chemical modifications. This approach yields that general dimensions of the site, its polarity and asymmetry features, the assignment of the DNP-contact residues and their three-dimensional coordinates.     

Immunochemical identification of vitellogenin in the serum of the newtTriturus cristatus

Summary The hematic yolk precursor — vitellogenin — has been identified immunochemically in the serum of estrogenized females of the newtTriturus cristatus by employing an antiserum prepared against yolk proteins.     

Von Pasch zu Hilbert

Ohne Zusammenfassung Vorgelegt von B. L. van der Waerden Meinem verehrten Lehrer Herrn Prof. Dr. Willy Hartner zum 70. Geburtstag     

Effect of chronic hypo and hypervitaminosis C on the brush border enzymes and the intestinal uptake of glucose and alanine

Summary Brush border sucrase and alkaline phosphatase activities are considerably enhanced in the intestine of ascorbic acid deficient guinea-pigs. Similar increase in the uptake of D-glucose and L-alanine also occurs in chronic vitamin C deficiency. However the permeability of D-glucose and L-alanine in the intestine of animals fed with large doses of vitamin C is severely depressed, with a reduction in the levels of sucrase and alkaline phosphatase activities.     

Effect of lesions of the locus coeruleus complex on the circadian rhythm of plasma corticosterone in the mouse

Summary An apparently transient elevation of basal morning (08.00 h) plasma corticosterone levels in male mice was found 48 h after bilateral electrolytic lesions of the brainstem locus coeruleus complex but was not observed 6 weeks after lesioning.Supported by Alfred P. Sloan Foundation research fellowships awarded to W.G. Luttge and S.F. Zornetzer.     

Age dependency of the primary immune response in the hereditary pituitary dwarf and normal snell-bagg mouse

Riassunto Vengono riportati i dati relativi allo sviluppo in funzione dell'età, della reatività immunologica primaria nel topo con nanismo ereditario preipofisario e nel corrispondente fratello normale. Mentre in quest'ultimo si è notato un graduale incremento della reattività immunitaria di tipo primario soprattutto a partire dalla fine del periodo di allattamento, nel topo nano la reattività immunitaria primaria è rimasta costante nel tempo su bassi livelli anche dopo lo svezzamento. Alla luce dei dati sperimentali riportati viene ipotizzata l'esistenza di un controllo ipofisario della reattività immunitaria primaria.