Shwartzman phenomenon without endotoxin preparation

Zusammenfassung Kasein, Pepton bzw. Baktokasiton wurde als präparierende Erstinjektion für lokalisiertes Shwartzman-Phänomen an Kaninchen verwendet. Nach provozierender i.v. Endotoxininjektion kommt es zum typischen Shwartzman-Phänomen. Da die verwendeten Substanzen Chemotaxis von Leukozyten verursachen, ist anzunehmen, dass die an Stelle der präparierenden Injektion angesammelten Leukozyten in der Ausbildung des Shwartzman-Phänomens eine vorwiegende Rolle spielen.     

Molecular aspects of 2 human urinary glycoproteins with histocompatibility antigen (HLA) serological activity]

Two serologically active urinary glycoproteins (HLA-A 9 and HLA-B 12) were isolated from urine provided by a patient suffering from tubular proteinuria. Their N-terminal sequences were automatically determined. The latter were identical with the sequence of another urinary glycoprotein (protein HC). The relationship between protein HC and the serological activity is discussed.     

Effect of orotic acid on liver glycogen of different animal species

Summary The effect of orotic acid on the liver glycogen content in the mice, frogs and catfish was studied. It was observed that the orotic acid significantly increases the glycogen content in the liver of mice and catfish as it does in rats. On the other hand it causes a fall of the glycogen level in frogs in experiments made both in autumn and spring. This effect was modified by amino acids administrated together with orotic acid.     

Decrease of mast cells in regional lymph nodes in response to allogeneic antigens and syngeneic tumor antigens

Summary The absolute number of mast cells in regional lymph nodes decreases on the 5th day after stimulation by allogeneic lymphocytes and semisyngeneic leukaemic cells, despite the enlargement of stimulated lymph nodes. It is postulated that the reaction of lymphatic mast cells could be a sensitive test for tissue incompatibility, and probably also for the presence of tumor associated antigens.     

Interaction of cocaine and bunaphtide on the3H-norepinephrine uptake mechanism on isolated left atrium of guinea-pig

Summary Bunaphtide induces a blockade in the³H-norepinephrine uptake and retention in the isolated guinea-pig left atrium. However, this blockade does not seems to be related with the cardiodepressant effect of the drug.     

The effect of NADH and NAD+ on the proteolysis of lactate dehydrogenase isozymes by trypsin

Résumé L'effet de la NADH et NAD⁺ sur la protéolyse de la lacticodéhydrogénase isoenzyme 1 (LDH 1) et isoenzyme 5 (LDH 5) par la trypsine fut étudié. Les résultats montrent que la NAD⁺ exerce une protection contre la protéolyse de la LDH 1. Mais ni la NADH ni la NAD⁺ ne protègent contre la protéolyse de la LDH 5.     

Ultra-remote stereocontrol by conformational communication of information along a carbon chain

Many receptors and allosteric proteins function through binding of a molecule to induce a conformational change, which then influences a remote active site. In synthetic systems, comparable intramolecular information transfer can be effected by using the shape of one part of a molecule to control the stereoselectivity of reactions occurring some distance away. However, the need for direct communication with the reaction site usually limits such remote stereocontrol to distances of not more than about five bond lengths. Cyclic structures overcome this problem by allowing the controlling centre and the reaction site to approach each other, but the information transfer spans only short absolute distances. Truly remote stereocontrol can, however, be achieved with rigid compounds containing amide groups: the conformation of the amides can be controlled by stereogenic centres and responds to that of neighbouring amide groups and in turn influences stereoselective reactions. This strategy has allowed remote stereocontrol spanning 8 (ref. 11) or 9 (ref. 12) bonds. Here we demonstrate stereocontrol over a reaction taking place more than 20 bond lengths from the controlling centre, corresponding to a linear distance of over 2.5 nm. This transmission of information, achieved by conformational changes relayed through the molecule, provides a chemical model of allostery and might serve as a molecular mechanism for communicating and processing information.