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101.
102.
Raxworthy CJ Martinez-Meyer E Horning N Nussbaum RA Schneider GE Ortega-Huerta MA Townsend Peterson A 《Nature》2003,426(6968):837-841
Despite the importance of tropical biodiversity, informative species distributional data are seldom available for biogeographical study or setting conservation priorities. Modelling ecological niche distributions of species offers a potential solution; however, the utility of old locality data from museums, and of more recent remotely sensed satellite data, remains poorly explored, especially for rapidly changing tropical landscapes. Using 29 modern data sets of environmental land coverage and 621 chameleon occurrence localities from Madagascar (historical and recent), here we demonstrate a significant ability of our niche models in predicting species distribution. At 11 recently inventoried sites, highest predictive success (85.1%) was obtained for models based only on modern occurrence data (74.7% and 82.8% predictive success, respectively, for pre-1978 and all data combined). Notably, these models also identified three intersecting areas of over-prediction that recently yielded seven chameleon species new to science. We conclude that ecological niche modelling using recent locality records and readily available environmental coverage data provides informative biogeographical data for poorly known tropical landscapes, and offers innovative potential for the discovery of unknown distributional areas and unknown species. 相似文献
103.
Identification of the gene altered in Berardinelli-Seip congenital lipodystrophy on chromosome 11q13
Magré J Delépine M Khallouf E Gedde-Dahl T Van Maldergem L Sobel E Papp J Meier M Mégarbané A Bachy A Verloes A d'Abronzo FH Seemanova E Assan R Baudic N Bourut C Czernichow P Huet F Grigorescu F de Kerdanet M Lacombe D Labrune P Lanza M Loret H Matsuda F Navarro J Nivelon-Chevalier A Polak M Robert JJ Tric P Tubiana-Rufi N Vigouroux C Weissenbach J Savasta S Maassen JA Trygstad O Bogalho P Freitas P Medina JL Bonnicci F Joffe BI Loyson G Panz VR Raal FJ O'Rahilly S Stephenson T Kahn CR 《Nature genetics》2001,28(4):365-370
Congenital generalized lipodystrophy, or Berardinelli-Seip syndrome (BSCL), is a rare autosomal recessive disease characterized by a near-absence of adipose tissue from birth or early infancy and severe insulin resistance. Other clinical and biological features include acanthosis nigricans, hyperandrogenism, muscular hypertrophy, hepatomegaly, altered glucose tolerance or diabetes mellitus, and hypertriglyceridemia. A locus (BSCL1) has been mapped to 9q34 with evidence of heterogeneity. Here, we report a genome screen of nine BSCL families from two geographical clusters (in Lebanon and Norway). We identified a new disease locus, designated BSCL2, within the 2.5-Mb interval flanked by markers D11S4076 and D11S480 on chromosome 11q13. Analysis of 20 additional families of various ethnic origins led to the identification of 11 families in which the disease cosegregates with the 11q13 locus; the remaining families provide confirmation of linkage to 9q34. Sequence analysis of genes located in the 11q13 interval disclosed mutations in a gene homologous to the murine guanine nucleotide-binding protein (G protein), gamma3-linked gene (Gng3lg) in all BSCL2-linked families. BSCL2 is most highly expressed in brain and testis and encodes a protein (which we have called seipin) of unknown function. Most of the variants are null mutations and probably result in a severe disruption of the protein. These findings are of general importance for understanding the molecular mechanisms underlying regulation of body fat distribution and insulin resistance. 相似文献
104.
Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer 总被引:25,自引:0,他引:25
Fraga MF Ballestar E Villar-Garea A Boix-Chornet M Espada J Schotta G Bonaldi T Haydon C Ropero S Petrie K Iyer NG Pérez-Rosado A Calvo E Lopez JA Cano A Calasanz MJ Colomer D Piris MA Ahn N Imhof A Caldas C Jenuwein T Esteller M 《Nature genetics》2005,37(4):391-400
CpG island hypermethylation and global genomic hypomethylation are common epigenetic features of cancer cells. Less attention has been focused on histone modifications in cancer cells. We characterized post-translational modifications to histone H4 in a comprehensive panel of normal tissues, cancer cell lines and primary tumors. Using immunodetection, high-performance capillary electrophoresis and mass spectrometry, we found that cancer cells had a loss of monoacetylated and trimethylated forms of histone H4. These changes appeared early and accumulated during the tumorigenic process, as we showed in a mouse model of multistage skin carcinogenesis. The losses occurred predominantly at the acetylated Lys16 and trimethylated Lys20 residues of histone H4 and were associated with the hypomethylation of DNA repetitive sequences, a well-known characteristic of cancer cells. Our data suggest that the global loss of monoacetylation and trimethylation of histone H4 is a common hallmark of human tumor cells. 相似文献
105.
Lebreton JP Witasse O Sollazzo C Blancquaert T Couzin P Schipper AM Jones JB Matson DL Gurvits LI Atkinson DH Kazeminejad B Pérez-Ayúcar M 《Nature》2005,438(7069):758-764
Titan, Saturn's largest moon, is the only Solar System planetary body other than Earth with a thick nitrogen atmosphere. The Voyager spacecraft confirmed that methane was the second-most abundant atmospheric constituent in Titan's atmosphere, and revealed a rich organic chemistry, but its cameras could not see through the thick organic haze. After a seven-year interplanetary journey on board the Cassini orbiter, the Huygens probe was released on 25 December 2004. It reached the upper layer of Titan's atmosphere on 14 January and landed softly after a parachute descent of almost 2.5 hours. Here we report an overview of the Huygens mission, which enabled studies of the atmosphere and surface, including in situ sampling of the organic chemistry, and revealed an Earth-like landscape. The probe descended over the boundary between a bright icy terrain eroded by fluvial activity--probably due to methane-and a darker area that looked like a river- or lake-bed. Post-landing images showed centimetre-sized surface details. 相似文献
106.
Thuiller W Araújo MB Pearson RG Whittaker RJ Brotons L Lavorel S 《Nature》2004,430(6995):1 p following 33; discussion following 33
Thomas et al. model species-distribution responses to a range of climate-warming scenarios and use a novel application of the species-area relationship to estimate that 15-37% of modelled species in various regions of the world will be committed to extinction by 2050. Although we acknowledge the efforts that they make to measure the uncertainties associated with different climate scenarios, species' dispersal abilities and z values (predictions ranged from 5.6% to 78.6% extinctions), we find that two additional sources of uncertainty may substantially increase the variability in predictions. 相似文献
107.
Summary This work reports some findings which will aid us in our understanding of the female phase ofPisum sativum embryology. We have observed that the central planes between one ovule and the next form an angle of 60°. We suggest that this ovule arrangement may make it easier for the pollen tube to reach the ovular micropyle in the fertilization process. On the other hand, ovary and ovule growth do not depend on the megasporogenesis stage but have individual characteristics for each plant, every one depending on its own phenotype.Acknowledgments. This work has been supported by a grant of the Plan de formación de Personal Investigador and by the Comisión Asesora para la Investigación Científica y Técnica, projects Nos 613/02 and 613/10. 相似文献
108.
de Lucas M Davière JM Rodríguez-Falcón M Pontin M Iglesias-Pedraz JM Lorrain S Fankhauser C Blázquez MA Titarenko E Prat S 《Nature》2008,451(7177):480-484
109.
Álvaro L. Peña Cantero Estela Roig Ferrer Thais P. Miranda 《Journal of Natural History》2017,51(25-26):1437-1477
Antarctoscyphus is one of the most characteristic genera of Antarctic benthic hydroids, with nine of the 10 known species considered to be endemic to the Antarctic; only Antarctoscyphus elongatus is also present in the sub-Antarctic region of Kerguelen. Accordingly, the genus was considered to have an Antarctic–Kerguelen distribution. Here we present the results of the study of the species of Antarctoscyphus collected from different Antarctic areas and from the Magellan region, during several expeditions under the United States Antarctic Research Program between 1958 and 1986. A scanning electron microscopy survey of all known species of the genus was carried out. Eight of the 10 known species of Antarctoscyphus were found in the collection, with A. spiralis and A. elongatus being the most frequently found species, whereas A. biformis, A. fragilis and A. gruzovi were found only once. The type material of A. biformis was reviewed and re-described. This study represents the second records for A. biformis and A. fragilis. The new records allow updating of the biogeographic knowledge on the distribution of several species: A. mawsoni, so far considered endemic to East Antarctica, and A. asymmetricus, considered endemic to West Antarctica, are here considered to have a Circum-Antarctic distribution. Additionally, A. fragilis, previously considered endemic to the Weddell Sea, is now considered to have a West Antarctic–Patagonian distribution, as it was recorded off the Pacific Magellan region. The records gathered here allow us to change the distribution pattern of the genus from Antarctic–Kerguelen to Pan-Antarctic. The study has allowed us to increase the known bathymetric range for some species, some reaching much deeper waters than previously known. Hence, A. fragilis, A. grandis and A. mawsoni, hitherto considered shelf species, are reported from bathyal bottoms of the continental slope. A general discussion on the bathymetric and geographic distribution of all known species is included.
www.zoobank.org/urn:lsid:zoobank.org:pub:1C7ED3F2-3FF1-4C5C-85BB-FAAF557AC2ED 相似文献
110.
Diego Damásio de Lima Daniel Pacheco Lacerda Miguel Afonso Sellitto 《Systemic Practice and Action Research》2017,30(3):295-316
The purpose of this article is to analyze systemically the Brazilian production chain of semiconductors. The specific objectives of this article are to represent the chain systemically and to identify key variables and leverage points that can increase the overall performance of the semiconductor industry. The research method is qualitative modelling. Eleven practitioners of the industry answered a questionnaire approaching various aspects of the semiconductor industry in Brazil. By a systemic approach, the complex behavior present in the industry was considered. By content analysis, we identified patterns in the speech of the respondents. Texts fragments allowed the identification of key themes and variables present in the system. The association among key variables and complex behavior helped to build a systemic structure, aimed at representing the main relationships in the system. From the systemic structure, eight leverage points were identified and discussed. The key implications of the findings are the damage that cheap imports make in the local market; the need of strong public policies that include more than tax reduction, but also local conditions, like clusters or technological parks, for the high-tech manufacture; and the promotion of conditions that stimulate private investment in the industry. 相似文献