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Summary Mycoside Cm, m.p. 198–200° []D = – 31° (CHCl3), a new peptido-glycolipid isolated fromMycobacterium marianum, has the approximate molecular formula C108H185N7O28 and gives on hydrolysis seven molecules ofd-amino acids (oned-phenylalanine, threed-allo-threonine, threed-alanine), three molecules of 6-deoxyhexoses (one 6-deoxy-talose of as yet undetermined configuration and two molecules of 3,4-di-O-methyl-l-rhamnose); the lipid moiety of mycoside Cm is a hydroxy-acid of approximate formula C50H96O3; three O-acetyl groups are also present. The preliminary formula (I) is proposed for mycoside Cm.

60ème communication sur les constitutants des Mycobactéries; 59ème comm. voir: ref. 7.

Ce travail a bénéficié d'une subvention de la Fondation Waksman pour le développement des Études microbiologiques en France, et d'une subvention du National Institute of Allergy and Infectious Diseases (Grant E 28 38).  相似文献   
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We investigate the effects of a complex sampling design on the estimation of mixture models. An approximate or pseudo likelihood approach is proposed to obtain consistent estimates of class-specific parameters when the sample arises from such a complex design. The effects of ignoring the sample design are demonstrated empirically in the context of an international value segmentation study in which a multinomial mixture model is applied to identify segment-level value rankings. The analysis reveals that ignoring the sample design results in both an incorrect number of segments as identified by information criteria and biased estimates of segment-level parameters.  相似文献   
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A predisposition for thoracic aortic aneurysms leading to acute aortic dissections can be inherited in families in an autosomal dominant manner. Genome-wide linkage analysis of two large unrelated families with thoracic aortic disease followed by whole-exome sequencing of affected relatives identified causative mutations in TGFB2. These mutations-a frameshift mutation in exon 6 and a nonsense mutation in exon 4-segregated with disease with a combined logarithm of odds (LOD) score of 7.7. Sanger sequencing of 276 probands from families with inherited thoracic aortic disease identified 2 additional TGFB2 mutations. TGFB2 encodes transforming growth factor (TGF)-β2, and the mutations are predicted to cause haploinsufficiency for TGFB2; however, aortic tissue from cases paradoxically shows increased TGF-β2 expression and immunostaining. Thus, haploinsufficiency for TGFB2 predisposes to thoracic aortic disease, suggesting that the initial pathway driving disease is decreased cellular TGF-β2 levels leading to a secondary increase in TGF-β2 production in the diseased aorta.  相似文献   
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High plant diversity is needed to maintain ecosystem services   总被引:3,自引:0,他引:3  
Biodiversity is rapidly declining worldwide, and there is consensus that this can decrease ecosystem functioning and services. It remains unclear, though, whether few or many of the species in an ecosystem are needed to sustain the provisioning of ecosystem services. It has been hypothesized that most species would promote ecosystem services if many times, places, functions and environmental changes were considered; however, no previous study has considered all of these factors together. Here we show that 84% of the 147 grassland plant species studied in 17 biodiversity experiments promoted ecosystem functioning at least once. Different species promoted ecosystem functioning during different years, at different places, for different functions and under different environmental change scenarios. Furthermore, the species needed to provide one function during multiple years were not the same as those needed to provide multiple functions within one year. Our results indicate that even more species will be needed to maintain ecosystem functioning and services than previously suggested by studies that have either (1) considered only the number of species needed to promote one function under one set of environmental conditions, or (2) separately considered the importance of biodiversity for providing ecosystem functioning across multiple years, places, functions or environmental change scenarios. Therefore, although species may appear functionally redundant when one function is considered under one set of environmental conditions, many species are needed to maintain multiple functions at multiple times and places in a changing world.  相似文献   
109.
Downs JA  Nussenzweig MC  Nussenzweig A 《Nature》2007,447(7147):951-958
The integrity of the genome is frequently challenged by double-strand breaks in the DNA. Defects in the cellular response to double-strand breaks are a major cause of cancer and other age-related pathologies; therefore, much effort has been directed at understanding the enzymatic mechanisms involved in recognizing, signalling and repairing double-strand breaks. Recent work indicates that chromatin - the fibres into which DNA is packaged with a proteinaceous structural polymer - has an important role in initiating, propagating and terminating this cellular response to DNA damage.  相似文献   
110.
Copepod hatching success in marine ecosystems with high diatom concentrations   总被引:22,自引:0,他引:22  
Diatoms dominate spring bloom phytoplankton assemblages in temperate waters and coastal upwelling regions of the global ocean. Copepods usually dominate the zooplankton in these regions and are the prey of many larval fish species. Recent laboratory studies suggest that diatoms may have a deleterious effect on the success of copepod egg hatching. These findings challenge the classical view of marine food-web energy flow from diatoms to fish by means of copepods. Egg mortality is an important factor in copepod population dynamics, thus, if diatoms have a deleterious in situ effect, paradoxically, high diatom abundance could limit secondary production. Therefore, the current understanding of energy transfer from primary production to fisheries in some of the most productive and economically important marine ecosystems may be seriously flawed. Here we present in situ estimates of copepod egg hatching success from twelve globally distributed areas, where diatoms dominate the phytoplankton assemblage. We did not observe a negative relationship between copepod egg hatching success and either diatom biomass or dominance in the microplankton in any of these regions. The classical model for diatom-dominated system remains valid.  相似文献   
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