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931.
Protein deacetylation by sirtuins: delineating a post-translational regulatory program responsive to nutrient and redox stressors 总被引:1,自引:1,他引:0
Lysine acetylation/deacetylation is increasingly being recognized as common post-translational modification that appears to
be broadly operational throughout the cell. The functional roles of these modifications, outside of the nucleus, have not
been extensively studied. Moreover, as acetyl-CoA donates the acetyl group for acetylation, nutrient availability and energetic
status may be pivotal in this modification. Similarly, nutrient limitation is associated with the deacetylation reaction.
This modification is orchestrated by a novel family of sirtuin deacetylases that function in a nutrient and redox dependent
manner and targets non-histone protein deacetylation. In compartment-specific locations, candidate target proteins undergoing
lysine-residue deacetylation are being identified. Through these investigations, the functional role of this post-translational
modification is being delineated. We review the sirtuin family proteins, discuss their functional effects on target proteins,
and postulate on potential biological programs and disease processes that may be modified by sirtuin-mediated deacetylation
of target proteins. 相似文献
932.
Christoph-Erik Mayer Barbara Haigl Florian Jantscher Gerald Siegwart Michael Grusch Walter Berger Hedwig Sutterlüty 《Cellular and molecular life sciences : CMLS》2010,67(19):3299-3311
Sprouty2 is an important inhibitor of cell proliferation and signal transduction. In this study, we found a bimodal expression
of Sprouty2 protein during cell cycle progression after exit from quiescence, whereas elevated Sprouty4 expression in the
G1 phase stayed high throughout the rest of the cell cycle. Induction of the mitogen-activated protein kinase via activated
Ras was crucial for increased Sprouty2 expression at the G0/G1 transition. Following the first peak, accelerated proteasomal
protein degradation caused a transient attenuation of Sprouty2 abundance during late G1. Since the decline in its expression
was abolished by dominant negative c-Cbl and the timely restricted interaction between Sprouty2 and c-Cbl disappeared at the
second peak of Sprouty2 expression, we conclude that the second phase in the cell cycle-specific expression profile of Sprouty2
is solely dependent on ubiquitination by c-Cbl. Our results suggest that Sprouty2 abundance is the result of strictly coordinated
activities of Ras and c-Cbl. 相似文献
933.
Ludwig Heesen Michael Peitz Laura Torres-Benito Irmgard Hölker Kristina Hupperich Kristina Dobrindt Johannes Jungverdorben Swetlana Ritzenhofen Beatrice Weykopf Daniela Eckert Seyyed Mohsen Hosseini-Barkooie Markus Storbeck Noemi Fusaki Renata Lonigro Raoul Heller Min Jeong Kye Oliver Brüstle Brunhilde Wirth 《Cellular and molecular life sciences : CMLS》2016,73(10):2089-2104
934.
The zoeal stages of Hiplyra variegata are described and illustrated for the first time. Zoea I was obtained from an ovigerous female, and the zoea II and zoea III stages were captured in the plankton (their identity was confirmed by rearing some of them from earlier stages). Comparisons are made with the only other species of the genus of which larvae are known, i.e. H. platycheir. The presence of a lateral spine on the carapace of zoea I is one of the most important characters that can be used for easy recognition of H. variegata. It is important to note that the third zoea of H. variegata has four small spines at each posterolateral margin of the carapace, in contrast to three spines in other species. 相似文献
935.
We compared vertebrate populations between the two major islands (paoha and Negit) in Mono Lake, California and the adjacent mainland to further elucidate the mechanisms underlying island colonization. Deer mice ( Peromyscus maniculatus ) and montane voles ( Microtus montanus ) were captured on Paoha, but only deer mice were captured on Negit. In contrast, eight species of rodents were captured on the mainland. Overall rodent abundance on Paoha and the mainland was similar, but on Negit it was about three times greater than on Paoha or the mainland. Adult deer mice from Paoha were significantly ( P Canis latrans ) and one or two species of lagomorphs were observed on the islands and the mainland. No amphibians or reptiles were found on the islands; both occurred in low numbers on the mainland. Rafting and human transport are probable means of colonization for mice and voles. The occurrence of coyotes on the islands may have modified historic predator-prey relationships, and thus the population of rodents and lagomorphs. 相似文献
936.
Two mule deer herds were studied on comparable, adjacent winter ranges in Utah. Significant differences in overwinter fawn survival were attributed to intensive predator control. 相似文献
937.
Counts of Double-crested Cormorants ( Phalacrocorax auritus ) were made at 13 reservoirs and lakes in southwestern Utah during 1989-91 to determine current abundance of that species. Food habits of cormorants were studied at three of the reservoirs in 1989. Data were also collected on trout abundance during standardized gill-netting to make comparisons between cormorant numbers and trout abundance. Cormorants were observed at all waters studied except one and were generally most numerous during the spring as they migrated through the area. Estimated cormorant abundance ranged from 0 to 34 bird-days per ha and was highest at the larger, lower-elevation reservoirs. Cormorants were summer residents at several of the larger reservoirs and nested successfully at Piute Reservoir. Trout accounted for 24-81% of the diet of cormorants, with Utah chubs constituting most of the remainder of the diet. Estimates of the annual consumption of fish by cormorants ranged from 0 to 15.8 kg per ha. The index of trout abundance was inversely related to cormorant abundance ( P < .01) at the waters studied. Cormorants apparently have increased in numbers and extended their range in southwestern Utah during the past decade. This change may be the result of factors that have led to similar changes throughout North America as well as some factors unique to Utah. Methods to mitigate the impact of predation by piscivorous birds of sportfisheries are discussed. The Utah Division of Wildlife Resources has initiated a new management plan at Minersville Reservoir that incorporates piscivorous birds into sportfish management at that reservoir. 相似文献
938.
We surveyed bats using echolocation calls near inactive mines in the western Great Basin from 2003 to 2007. We identified 14 species of bats during our surveys, with Myotis lucifugus and Lasionycteris noctivagans found at 9 sites and Myotis evotis and Tadarida brasiliensis at 7 sites; all other species were found at less than one-half of the sites. Euderma maculatum, a state-protected species in Nevada, was recorded at 2 sites. Our work provides information that will be useful in managing bat habitat, especially with regard to mining activities. 相似文献
939.
The Bonneville cutthroat trout ( Oncorhynchus clarki utah ; BCT) was once abundant throughout the Bonneville Basin. In southwestern Utah, however, only 3 local populations of the subspecies were known to exist in 1977, when conservation efforts to protect and replicate them began. By 1995 remnant populations were known in 6 streams, and replicate populations had been established in an additional 16. Populations of BCT in southwestern Utah streams were survey by electrofishing in 1994 and 1995 to describe the subspecies' status. Estimated densities of age-1 and older BCT ranged from 118 to 546 fish per km. Biomass estimates ranged from 8 to 64 kg per ha. Several age groups of BCT were collected at most locations. Six populations were classified as self-sustaining, 9 as expanding through natural recruitment, 6 as new, and 1 as hybridized. Overall status of BCT in southwestern Utah has improved since 1977, but conservation measures must continue to maintain a positive trend. 相似文献
940.
Seasonal movements, roost-site fidelity, and foraging activity patterns are largely unknown for western populations of Townsend's big-eared bat ( Plecotus townsendii ). We used miniature radiotelemetry units to track springtime movements of six bats inhabiting forested lava flows in central Oregon, and found that bats moved up to 24 km from hibernacula to foraging areas. Individual bats returned to the same foraging area on successive nights but shifted to different areas in presumed response to changes in insect availability. Both sexes apparently use a series of interim roost sites between emergence from hibernation and the time females enter into maternity colonies, with little individual fidelity to these sites. In regions characterized by extensive lava-flow topography, suitable daytime roosts are numerous and dispersed over a large area, allowing bats to move relatively great distances to locate foraging ranges. Hence, the actual area of concern for effective management of individual populations can be considerably larger than indicated solely by locations of hibernacula and maternity caves of this declining species. 相似文献