Aspirin-like drugs may block pain independently of prostaglandin synthesis inhibition

Summary Using flurbiprofen, a chiral anti-inflammatory and analgesic 2-arylpropionic acid derivative, the enantiomers of which are not converted to each other (less than 5%) in rats or man, we obtained evidence that prostaglandin synthesis inhibition is primarily mediating the anti-inflammatory activity but prostaglandin synthesis independent mechanisms contribute to the analgesic effects. Thus, the S-form inhibited prostaglandin synthesis, inflammation and nociception in rats. The R-form had much less effect on prostaglandin synthesis and did not affect inflammation. It did, however, block nociception in rats almost as potently as the S-form. S-flurbiprofen, in contrast to the R-form, was clearly ulcerogenic in the gastrointestinal mucosa. These results indicate additional molecular mechanisms of analgesia and suggest the use of R-arylpropionic acids as analgesics.     

激光开槽、埋槽电极硅太阳电池

报道一种新颖的激光开槽、埋槽电极硅太阳电池的结构、工艺流程及其研制结果。在ＡＭ１．５，２５℃，１００ｍＷ／ｃｍ２的条件下，以面积为４５ｃｍ３的３６片硅片研制的硅太阳电池的输出参数的平均值为ＪＳＣ＝３６．１ｍＡ／ｃｍ２，Ｖ∞＝６３３ｍＶ，Ｆ．Ｆ．＝０．７９８，η＝１８．２３％，最后分析了种高性能硅太阳电池的设计特点。     

A small GTP-binding protein dissociates from synaptic vesicles during exocytosis.

Low-molecular-weight GTP-binding proteins are strong candidates for regulators of membrane traffic. In yeast, mutations in the sec4 or ypt1 genes encoding small GTP-binding proteins inhibit constitutive membrane flow at the plasma membrane or Golgi complex, respectively. It has been suggested that membrane fusion-fission events are regulated by cycling of small GTP-binding proteins between a membrane-bound and free state, but although most of these small proteins are found in both soluble and tightly membrane-bound forms, there is no direct evidence to support such cycling. In rat brain a small GTP-binding protein, rab3A, is exclusively associated with synaptic vesicles, the secretory organelles of nerve terminals. Here we use isolated nerve terminals to study the fate of rab3A during synaptic vesicle exocytosis. We find that rab3A dissociates quantitatively from the vesicle membrane after Ca2(+)-dependent exocytosis and that this dissociation is partially reversible during recovery after stimulation. These results are direct evidence for an association-dissociation cycle of a small GTP-binding protein during traffic of its host membrane.     

在UBBE框架下考虑不肯定的上界的估计方法

对目前的ＵＢＢＥ模型进行了适当的推广，使在解决估计问题时可以考虑那些可能是误差上界的数值，并在此基础上提出了一种方法，能够通过对估计精度和可靠性进行合理的权衡确定所需估计值，实际案例研究结果表明所提方法能够较好地解决估计精度和可靠性之间的矛盾。     

Subset threshold autoregression

We develop in this paper an efficient way to select the best subset threshold autoregressive model. The proposed method uses a stochastic search idea. Differing from most conventional approaches, our method does not require us to fix the delay or the threshold parameters in advance. By adopting the Markov chain Monte Carlo techniques, we can identify the best subset model from a very large of number of possible models, and at the same time estimate the unknown parameters. A simulation experiment shows that the method is very effective. In its application to the US unemployment rate, the stochastic search method successfully selects lag one as the time delay and five best models from more than 4000 choices. Copyright © 2003 John Wiley & Sons, Ltd.     

网格技术发展现状研究

本文阐述了网格的概念、基础理论、国外一些国家的网格研究计划,并在此基础上对国内的研究工作提出了一些建议。     

The Huntington's disease candidate region exhibits many different haplotypes.

Analysis of 78 Huntington's disease (HD) chromosomes with multi-allele markers revealed 26 different haplotypes, suggesting a variety of independent HD mutations. The most frequent haplotype, accounting for about one third of disease chromosomes, suggests that the disease gene is between D4S182 and D4S180. However, the paucity of an expected class of chromosomes that can be related to this major haplotype by assuming single crossovers may reflect the operation of other mechanisms in creating haplotype diversity. Some of these mechanisms sustain alternative scenarios that do not require a multiple mutational origin for HD and/or its positioning between D4S182 and D4S180.     

Characterization of the rough endoplasmic reticulum ribosome-binding activity.

The rough endoplasmic reticulum membranes of mammalian cells contain specific ribosome-binding sites. A purification to apparent homogeneity of a negatively charged protein (ERp180) of relative molecular mass 180,000 (180 K) was reported which was proposed to function as a rough endoplasmic reticulum ribosome receptor. We report here that ribosome-binding site activity quantitatively solubilized from rough endoplasmic reticulum membranes does not cofractionate with ERp180. By contrast, ribosome-binding site activity fractionates as a much smaller, positively charged protein.     

在局域网上进行材料力学实验的探讨

本文提出了在局域网上进行材料力学实验预习、预约,实验成绩的评定,材料力学实验教学及管理这一新的体系。     

填补科技史名词空白 展现中国古代科学技术

一 第二届科学技术史名词审定委员会成立的意义 2007年1月15日，在全国科学技术名词审定委员会和中国科学院自然科学史研究所的共同努力下，“第二届科学技术史名词审定委员会”正式成立。自1988年第一届科学技术史名词审定委员会成立以来，海内外学术界关于中国科技史的研究取得了重大的成就，国内外交流空前活跃。2005年7月“第廿二届国际科学史大会”在北京召开，中国科技史的研究进一步走向国外。在全球科学史研究和学术交流日渐频繁的大背景下，如何进一步认识、规范和推广科技史名词术语，建立中国自己的科技史名词体系，便迫切地摆在了中国学者和相关机构的面前。第二届科学技术史名词审定委员会将在第一届委员会工作成就的基础上，改进以往之不足，尽快形成一个稳定、行之有效且高效率的编辑机制和渠道，填补我国科技史名词的空白，展现中国古代辉煌的科学技术。