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Positional cloning of a quantitative trait locus on chromosome 13q14 that influences immunoglobulin E levels and asthma 总被引:20,自引:0,他引:20
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Recent innovations in the Welsh economy have led to the view that the region's economy is likely to exhibit differential responses to financial and external shocks compared to the rest of the UK. This is examined with the aid of a structural VAR forecasting model for Wales. 相似文献
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Hydrophobic stabilization in T4 lysozyme determined directly by multiple substitutions of Ile 3 总被引:37,自引:0,他引:37
Replacing the isoleucine at amino-acid position three of bacteriophage T4 lysozyme causes changes in the thermodynamic stability of the protein that are directly related to the hydrophobicity of the substituted residue. Structural analysis confirms that the hydrophobic stabilization is proportional to the reduction of the surface area accessible to solvent on folding. 相似文献
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Matthews JM Kuschnig R Guenther DB Walker GA Moffat AF Rucinski SM Sasselov D Weiss WW Kusching R 《Nature》2004,430(6995):51-53
Pressure-driven (p-mode) oscillations at the surface of the Sun, resulting from sound waves travelling through the solar interior, are a powerful probe of solar structure, just as seismology can reveal details about the interior of the Earth. Astronomers have hoped to exploit p-mode asteroseismology in Sun-like stars to test detailed models of stellar structure and evolution, but the observations are extremely difficult. The bright star Procyon has been considered one of the best candidates for asteroseismology, on the basis of models and previous reports of p-modes detected in ground-based spectroscopy. Here we present a search for p-modes in 32 days of nearly continuous photometric satellite-based observations of Procyon. If there are p-modes in Procyon, they must have lifetimes less than 2-3 days and/or peak amplitudes <15 parts per million, which defy expectations from the Sun's oscillations and previous theoretical predictions. Target selection for future planned asteroseismology space missions may need to be reconsidered, as will the theory of stellar oscillations. 相似文献
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本文实验研究了在一种专门设计的具有多孔惰性介质燃烧器中预混火焰的燃烧特性.初步结果已经表明,在多孔介质中,热辐射对其火焰结构和燃烧速度有较大影响.燃烧速率比无惰性介质时提高了若干倍,最大火焰温度比普通的绝热预混火焰温度也高许多,火焰稳定性亦明显增强. 相似文献
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Treatment of turkey liver fructose-1,6--bisphosphatase with penicillin G progressively inactivated the enzyme and desensitized the enzyme toward high substrate inhibition. The treatment also led to reduced sensitivity to AMP inhibition and the loss of cooperative interaction among AMP-binding sites. These altered properties were not reversed by dialysis, but were prevented when treatment with penicillin G was perfomed in the presence of substrate. 相似文献