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排序方式: 共有176条查询结果,搜索用时 15 毫秒
141.
Eva C. Schwarz Christina Backes Arne Knörck Nicole Ludwig Petra Leidinger Cora Hoxha Gertrud Schwär Thomas Grossmann Sabine C. Müller Martin Hart Jan Haas Valentina Galata Isabelle Müller Tobias Fehlmann Hermann Eichler Andre Franke Benjamin Meder Eckart Meese Markus Hoth Andreas Keller 《Cellular and molecular life sciences : CMLS》2016,73(16):3169-3181
142.
Cambon-Thomsen A Thorisson GA Mabile L Andrieu S Bertier G Boeckhout M Cambon-Thomsen A Carpenter J Dagher G Dalgleish R Deschênes M di Donato JH Filocamo M Goldberg M Hewitt R Hofman P Kauffmann F Leitsalu L Lomba I Mabile L Melegh B Metspalu A Miranda L Napolitani F Oestergaard MZ Parodi B Pasterk M Reiche A Rial-Sebbag E Rivalle G Rochaix P Susbielle G Tarasova L Thomsen M Thorisson GA Zawati MH Zins M;BRIF workshop group 《Nature genetics》2011,43(6):503-504
143.
Regulation of flowering time: all roads lead to Rome 总被引:5,自引:0,他引:5
Plants undergo a major physiological change as they transition from vegetative growth to reproductive development. This transition
is a result of responses to various endogenous and exogenous signals that later integrate to result in flowering. Five genetically
defined pathways have been identified that control flowering. The vernalization pathway refers to the acceleration of flowering
on exposure to a long period of cold. The photoperiod pathway refers to regulation of flowering in response to day length
and quality of light perceived. The gibberellin pathway refers to the requirement of gibberellic acid for normal flowering
patterns. The autonomous pathway refers to endogenous regulators that are independent of the photoperiod and gibberellin pathways.
Most recently, an endogenous pathway that adds plant age to the control of flowering time has been described. The molecular
mechanisms of these pathways have been studied extensively in Arabidopsis
thaliana and several other flowering plants. 相似文献
144.
Oxidatively damaged biomolecules impair cellular functions and contribute to the pathology of a variety of diseases. RNA is
also attacked by reactive oxygen species, and oxidized RNA is increasingly recognized as an important contributor to neurodegenerative
complications in humans. Recently, evidence has accumulated supporting the notion that tRNA is involved in cellular responses
to various stress conditions. This review focuses on the intriguing consequences of oxidative modification of tRNA at the
structural and functional level. 相似文献
145.
Hillmer AM Brockschmidt FF Hanneken S Eigelshoven S Steffens M Flaquer A Herms S Becker T Kortüm AK Nyholt DR Zhao ZZ Montgomery GW Martin NG Mühleisen TW Alblas MA Moebus S Jöckel KH Bröcker-Preuss M Erbel R Reinartz R Betz RC Cichon S Propping P Baur MP Wienker TF Kruse R Nöthen MM 《Nature genetics》2008,40(11):1279-1281
We carried out a genome-wide association study in 296 individuals with male-pattern baldness (androgenetic alopecia) and 347 controls. We then investigated the 30 best SNPs in an independent replication sample and found highly significant association for five SNPs on chromosome 20p11 (rs2180439 combined P = 2.7 x 10(-15)). No interaction was detected with the X-chromosomal androgen receptor locus, suggesting that the 20p11 locus has a role in a yet-to-be-identified androgen-independent pathway. 相似文献
146.
Molecular pathways driving disease-specific alterations of intestinal epithelial cells 总被引:1,自引:1,他引:0
Rocío López-Posadas Markus F. Neurath Imke Atreya 《Cellular and molecular life sciences : CMLS》2017,74(5):803-826
Due to the fact that chronic inflammation as well as tumorigenesis in the gut is crucially impacted by the fate of intestinal epithelial cells, our article provides a comprehensive overview of the composition, function, regulation and homeostasis of the gut epithelium. In particular, we focus on those aspects which were found to be altered in the context of inflammatory bowel diseases or colorectal cancer and also discuss potential molecular targets for a disease-specific therapeutic intervention. 相似文献
147.
Groesser L Herschberger E Ruetten A Ruivenkamp C Lopriore E Zutt M Langmann T Singer S Klingseisen L Schneider-Brachert W Toll A Real FX Landthaler M Hafner C 《Nature genetics》2012,44(7):783-787
Nevus sebaceous is a common congenital cutaneous malformation. Affected individuals may develop benign and malignant secondary tumors in the nevi during life. Schimmelpenning syndrome is characterized by the association of nevus sebaceous with extracutaneous abnormalities. We report that of 65 sebaceous nevi studied, 62 (95%) had mutations in the HRAS gene and 3 (5%) had mutations in the KRAS gene. The HRAS c.37G>C mutation, which results in a p.Gly13Arg substitution, was present in 91% of lesions. Nonlesional tissues from 18 individuals had a wild-type sequence, confirming genetic mosaicism. The HRAS c.37G>C mutation was also found in 8 of 8 associated secondary tumors. Mosaicism for HRAS c.37G>C and KRAS c.35G>A mutations was found in two individuals with Schimmelpenning syndrome. Functional analysis of HRAS c.37G>C mutant cells showed constitutive activation of the MAPK and PI3K-Akt signaling pathways. Our results indicate that nevus sebaceous and Schimmelpenning syndrome are caused by postzygotic HRAS and KRAS mutations. These mutations may predispose individuals to the development of secondary tumors in nevus sebaceous. 相似文献
148.
Broderick P Chubb D Johnson DC Weinhold N Försti A Lloyd A Olver B Ma YP Dobbins SE Walker BA Davies FE Gregory WA Child JA Ross FM Jackson GH Neben K Jauch A Hoffmann P Mühleisen TW Nöthen MM Moebus S Tomlinson IP Goldschmidt H Hemminki K Morgan GJ Houlston RS 《Nature genetics》2012,44(1):58-61
To identify risk variants for multiple myeloma, we conducted a genome-wide association study of 1,675 individuals with multiple myeloma and 5,903 control subjects. We identified risk loci for multiple myeloma at 3p22.1 (rs1052501 in ULK4; odds ratio (OR) = 1.32; P = 7.47 × 10(-9)) and 7p15.3 (rs4487645, OR = 1.38; P = 3.33 × 10(-15)). In addition, we observed a promising association at 2p23.3 (rs6746082, OR = 1.29; P = 1.22 × 10(-7)). Our study identifies new genomic regions associated with multiple myeloma risk that may lead to new etiological insights. 相似文献
149.
Since the reports three decades ago revealed that viruses are surprisingly abundant and efficiently infective in the ocean, marine viruses have generated a grea... 相似文献
150.
Attosecond science is based on steering electrons with the electric field of well controlled femtosecond laser pulses. It has led to the generation of extreme-ultraviolet pulses with a duration of less than 100 attoseconds (ref. 3; 1 as = 10(-18) s), to the measurement of intramolecular dynamics (by diffraction of an electron taken from the molecule under scrutiny) and to ultrafast electron holography. All these effects have been observed with atoms or molecules in the gas phase. Electrons liberated from solids by few-cycle laser pulses are also predicted to show a strong light-phase sensitivity, but only very small effects have been observed. Here we report that the spectra of electrons undergoing photoemission from a nanometre-scale tungsten tip show a dependence on the carrier-envelope phase of the laser, with a current modulation of up to 100 per cent. Depending on the carrier-envelope phase, electrons are emitted either from a single sub-500-attosecond interval of the 6-femtosecond laser pulse, or from two such intervals; the latter case leads to spectral interference. We also show that coherent elastic re-scattering of liberated electrons takes place at the metal surface. Owing to field enhancement at the tip, a simple laser oscillator reaches the peak electric field strengths required for attosecond experiments at 100-megahertz repetition rates, rendering complex amplified laser systems dispensable. Practically, this work represents a simple, extremely sensitive carrier-envelope phase sensor, which could be shrunk in volume to about one cubic centimetre. Our results indicate that the attosecond techniques developed with (and for) atoms and molecules can also be used with solids. In particular, we foresee subfemtosecond, subnanometre probing of collective electron dynamics (such as plasmon polaritons) in solid-state systems ranging in scale from mesoscopic solids to clusters and to single protruding atoms. 相似文献