Biochemical and autoradiographical distribution of hyaluronic acid in calf rib cartilage

Summary In calf rib cartilage, about one half of total hyaluronate is soluble with guanidinium hydrochloride, the other half only after collagenase treatment. Evidence is presented for its pericellular and intracellular distribution.Acknowledgment. This work was supported by grants from the Deutsche Forschungsgemeinschaft (Kl 193/10, Mo 183/5).     

Proteases of Antarctic krill--a new system for effective enzymatic debridement of necrotic ulcerations

The Antarctic krill (Euphausia superba) possesses an "over-dimensioned' digestive system, which is of vital importance for the survival of this euphaucean shrimp in the extreme marine environment. The isolated enzymes contain a well-balanced mixture of both endo- and exopeptidases, assuring fast and complete breakdown of proteinaceous material. These unique properties have now been shown to be extremely valuable for the effective removal of necrotic debris, fibrin or blood crusts in vitro. Therefore the krill enzymes should be considered as an important resource in the future management of necrotic wounds.     

The DNA helicase BRIP1 is defective in Fanconi anemia complementation group J

The protein predicted to be defective in individuals with Fanconi anemia complementation group J (FA-J), FANCJ, is a missing component in the Fanconi anemia pathway of genome maintenance. Here we identify pathogenic mutations in eight individuals with FA-J in the gene encoding the DEAH-box DNA helicase BRIP1, also called FANCJ. This finding is compelling evidence that the Fanconi anemia pathway functions through a direct physical interaction with DNA.     

Genetics,cytokines and human infectious disease: lessons from weakly pathogenic mycobacteria and salmonellae

Host genetic factors are important in determining the outcome of infections caused by intracellular pathogens, including mycobacteria and salmonellae, but until now have been poorly characterized. Recently, some individuals with severe infections due to otherwise weakly pathogenic mycobacteria (non-tuberculous mycobacteria or Mycobacterium bovis bacille Calmette-Guérin) or Salmonella species have been shown to be unable to produce or respond to interferon-gamma. This inability results from mutations in any of five genes encoding essential proteins of the type 1 cytokine cascade: interleukin-12p40, interleukin-12R beta 1, interferon-gamma R1, interferon-gamma R2 or STAT1. Ten syndromes have thus far been identified. Recent insights in genetically controlled host defense and susceptibility to mycobacterial disease are discussed.     

Mesothelzellveränderungen nach der intraperitonealen Injektion von denaturiertem Phytohaemagglutinin

Summary After the i.p. injection of heat denatured PHA, mesothelial cell changes are similar to those found after the application of natural PHA. While vacuolization of mesothelial cells and signet ring cell formation is strongly marked after the injection of natural PHA, this reaction is minor if denatured PHA is used. Furthermore, the peritoneal fluid does not contain hyaluronic acid in detectable amounts.

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Die Untersuchungen wurden mit finanzieller Unterstützung durch die Deutsche Forschungsgemeinschaft durchgeführt.