Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder

To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases and 6,209 controls and identified a region of strong association (rs10994336, P = 9.1 x 10(-9)) in ANK3 (ankyrin G). We also found further support for the previously reported CACNA1C (alpha 1C subunit of the L-type voltage-gated calcium channel; combined P = 7.0 x 10(-8), rs1006737). Our results suggest that ion channelopathies may be involved in the pathogenesis of bipolar disorder.     

tRNA splicing endonuclease mutations cause pontocerebellar hypoplasia

Pontocerebellar hypoplasias (PCH) represent a group of neurodegenerative autosomal recessive disorders with prenatal onset, atrophy or hypoplasia of the cerebellum, hypoplasia of the ventral pons, microcephaly, variable neocortical atrophy and severe mental and motor impairments. In two subtypes, PCH2 and PCH4, we identified mutations in three of the four different subunits of the tRNA-splicing endonuclease complex. Our findings point to RNA processing as a new basic cellular impairment in neurological disorders.     

Cellular modelling using P systems and process algebra

In this paper various molecular chemical interactions are modelled under different computational paradigms. P systems andπ-calculus are used to describe intra-cellular reactions like protein-protein interactions and gene regulation control.     

SD振子、吸引子的转迁过程及其特性

SD振子及SD吸引子的动力学行为决定于一个光滑参数α的连续变化。当α>0时,系统表现为光滑特征;当α=0时,系统表现为不连续特性。这是一个具有强非线性特征的振动系统,它提供了一个从光滑动力学行为向不连续动力学行为光滑转迁的典型示范,这种直接的转迁并不需要连续系统的过渡。当系统为光滑动力学性态时,表现出与Duffing系统类似的双井等标准动力学行为;当系统表现为不连续性态时,除表现为标准的双井动力学行为外,也表现出如类鞍点和类同宿轨道等非标准动力学行为,展示了这个系统的转迁过程和特性及其相应的吸引子的复杂动力学行为。