排序方式: 共有88条查询结果,搜索用时 31 毫秒
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提出参考资源模型结构,并给出其构造方法,研究其在建模导出过程中的支持作用.企业参考资源模型是一个资源的参考目录,在建立特定企业资源模型时,可以直接从参考资源模型中选取所需资源.参考资源模型的建立支持资源重组,缩短建模时间,从而加速建模的进程. 相似文献
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Star B Nederbragt AJ Jentoft S Grimholt U Malmstrøm M Gregers TF Rounge TB Paulsen J Solbakken MH Sharma A Wetten OF Lanzén A Winer R Knight J Vogel JH Aken B Andersen O Lagesen K Tooming-Klunderud A Edvardsen RB Tina KG Espelund M Nepal C Previti C Karlsen BO Moum T Skage M Berg PR Gjøen T Kuhl H Thorsen J Malde K Reinhardt R Du L Johansen SD Searle S Lien S Nilsen F Jonassen I Omholt SW Stenseth NC Jakobsen KS 《Nature》2011,477(7363):207-210
Atlantic cod (Gadus morhua) is a large, cold-adapted teleost that sustains long-standing commercial fisheries and incipient aquaculture. Here we present the genome sequence of Atlantic cod, showing evidence for complex thermal adaptations in its haemoglobin gene cluster and an unusual immune architecture compared to other sequenced vertebrates. The genome assembly was obtained exclusively by 454 sequencing of shotgun and paired-end libraries, and automated annotation identified 22,154 genes. The major histocompatibility complex (MHC)?II is a conserved feature of the adaptive immune system of jawed vertebrates, but we show that Atlantic cod has lost the genes for MHC?II, CD4 and invariant chain (Ii) that are essential for the function of this pathway. Nevertheless, Atlantic cod is not exceptionally susceptible to disease under natural conditions. We find a highly expanded number of MHC?I genes and a unique composition of its Toll-like receptor (TLR) families. This indicates how the Atlantic cod immune system has evolved compensatory mechanisms in both adaptive and innate immunity in the absence of MHC?II. These observations affect fundamental assumptions about the evolution of the adaptive immune system and its components in vertebrates. 相似文献
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mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake 总被引:2,自引:0,他引:2
Yilmaz ÖH Katajisto P Lamming DW Gültekin Y Bauer-Rowe KE Sengupta S Birsoy K Dursun A Yilmaz VO Selig M Nielsen GP Mino-Kenudson M Zukerberg LR Bhan AK Deshpande V Sabatini DM 《Nature》2012,486(7404):490-495
How adult tissue stem and niche cells respond to the nutritional state of an organism is not well understood. Here we find that Paneth cells, a key constituent of the mammalian intestinal stem-cell (ISC) niche, augment stem-cell function in response to calorie restriction. Calorie restriction acts by reducing mechanistic target of rapamycin complex 1 (mTORC1) signalling in Paneth cells, and the ISC-enhancing effects of calorie restriction can be mimicked by rapamycin. Calorie intake regulates mTORC1 in Paneth cells, but not ISCs, and forced activation of mTORC1 in Paneth cells during calorie restriction abolishes the ISC-augmenting effects of the niche. Finally, increased expression of bone stromal antigen 1 (Bst1) in Paneth cells—an ectoenzyme that produces the paracrine factor cyclic ADP ribose—mediates the effects of calorie restriction and rapamycin on ISC function. Our findings establish that mTORC1 non-cell-autonomously regulates stem-cell self-renewal, and highlight a significant role of the mammalian intestinal niche in coupling stem-cell function to organismal physiology. 相似文献
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中国农作物秸秆资源量及其“五料化”利用现状 总被引:1,自引:0,他引:1
农作物秸秆是十分宝贵的生物资源,资源丰富,秸秆"用则利,弃则害"。秸秆的高效综合利用能有效解决秸秆利用率低、转化率低、经济效益低、环境污染严重这"三低一重"的问题,对中国现代农业的可持续发展起重要的作用。本文分析了中国农作物秸秆资源数量及分布,介绍了秸秆资源综合利用技术的最新进展,包括肥料化、燃料化、饲料化、原料化和基料化("五料化")这些重点领域的应用。集约、循环、高效、充分利用秸秆资源是保护生态环境、节约可再生资源的需要,也是促进中国农业和农村社会经济实现可持续发展的必然要求。 相似文献
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用气象色谱和气象色谱-质谱联用方法对高原鼢鼠油脂中油酸含量进行了定量分析,并对方法的准确度进行了检验。结果发现,高原鼢鼠油脂中油酸含量为18.57%±0.43%,皂化和酯化最佳时间分别为15min和7min,油酸甲酯标准曲线回归系数r=0.9999,油酸甲酯色谱峰面积的相对偏差为0.0171,样品中油酸甲酯回收率为94.08%。 相似文献
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介绍了引文索引的功能及其异化过程,探讨了国内外科研学术绩效评价中引文数据的应用,分析了SCI及其衍生产品的科研绩效评价功能,阐述了SCI来源刊及其分区依据。 相似文献
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详细地介绍了一种利用电磁涡流信号检测淬火钢轨硬度的新型无损检测装置 .利用该装置可连续地实现钢轨踏面硬度的检测 ,并且通过应用计算机信号处理技术和图形技术 ,使得该装置的检测精度达到了工业测量的要求 . 相似文献
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以火箭式激振器为震源对高大结构物(即云南景洪澜沧江大桥主塔)进行了现场动力测试和分析,利用实测结构体系的动力特性,取得了场地土边界元参数,在考虑了土与结构相互作用的基础上,为选取全桥的抗震设计参数提供合理依据. 相似文献