Supernova--remnant origin of cosmic rays?

It is thought that Galactic cosmic-ray nuclei are gradually accelerated to high energies (up to about 300 TeV per nucleon, where 1 TeV is 10(12) eV) in the expanding shock waves connected with the remnants of powerful supernova explosions. However, this conjecture has eluded direct observational confirmation since it was first proposed in 1953 (ref. 3). Enomoto et al. claim to have finally found definitive evidence that corroborates this model, proposing that very-high-energy, TeV-range, gamma-rays from the supernova remnant (SNR) RX J1713.7-3946 are due to the interactions of energetic nuclei in this region. Here we argue that their claim is not supported by the existing multiwavelength spectrum of this source. The search for the origin(s) of Galactic cosmic-ray nuclei may be closing in on the long-suspected supernova-remnant sources, but it is not yet over.     

Effects of cysteine and N-acetyl cysteine on GSH content of brain of adult rats

Intraperitoneal injections of cysteine or N-acetyl cysteine induce a depletion of reduced glutathione (GSH) in rat brain. The doses required to promote GSH depletion are lower than those reported to cause a disseminate neurodegenerative syndrome. Since physiological GSH concentrations are required to maintain cell membranes, we suggest that consideration of the cysteine-induced GSH depletion is important in attempts to understand the mechanism of cysteine-induced cytotoxicity in brain.     

Generation of MHC class I ligands in the secretory and vesicular pathways

CD8⁺ T lymphocytes screen the surface of all cells in the body to detect pathogen infection or oncogenic transformation. They recognize peptides derived from cellular proteins displayed at the plasma membrane by major histocompatibility complex (MHC) class I molecules. Peptides are mostly by-products of cytosolic proteolytic enzymes. Peptidic ligands of MHC class I molecules are also generated in the secretory and vesicular pathways. Features of protein substrates, of proteases and of available MHC class I molecules for loading peptides in these compartments shape a singular collection of ligands that also contain different, longer, and lower affinity peptides than ligands produced in the cytosol. Especially in individuals who lack the transporters associated with antigen processing, TAP, and in infected and tumor cells where TAP is blocked, which thus have no supply of peptides derived from the cytosol, MHC class I ligands generated in the secretory and vesicular pathways contribute to shaping the CD8⁺ T lymphocyte response.     

Adversus Singularitates: The Ontology of Space–Time Singularities

I argue that there are no physical singularities in space–time. Singular space–time models do not belong to the ontology of the world, because of a simple reason: they are concepts, defective solutions of Einstein’s field equations. I discuss the actual implication of the so-called singularity theorems. In remarking the confusion and fog that emerge from the reification of singularities I hope to contribute to a better understanding of the possibilities and limits of the theory of general relativity.     

Outline of a Theory of Scientific Aesthetics

I offer a theory of art that is based on science. I maintain that, as any other human activity, art can be studied with the tools of science. This does not mean that art is scientific, but aesthetics, the theory of art, can be formulated in accord with our scientific knowledge. I present elucidations of the concepts of aesthetic experience, art, work of art, artistic movement, and I discuss the ontological status of artworks from the point of view of scientific philosophy.     

Dünnschichtstärkegelelektrophorese

Summary A modification ofSmithies starch gel electrophorese is presented. Thin starch gel layers (4 mm thick) were prepared on glass plates and used for analytical or preparative electrophorese.