Low dose oral cannabinoid therapy reduces progression of atherosclerosis in mice

Atherosclerosis is a chronic inflammatory disease, and is the primary cause of heart disease and stroke in Western countries. Derivatives of cannabinoids such as delta-9-tetrahydrocannabinol (THC) modulate immune functions and therefore have potential for the treatment of inflammatory diseases. We investigated the effects of THC in a murine model of established atherosclerosis. Oral administration of THC (1 mg kg(-1) per day) resulted in significant inhibition of disease progression. This effective dose is lower than the dose usually associated with psychotropic effects of THC. Furthermore, we detected the CB2 receptor (the main cannabinoid receptor expressed on immune cells) in both human and mouse atherosclerotic plaques. Lymphoid cells isolated from THC-treated mice showed diminished proliferation capacity and decreased interferon-gamma secretion. Macrophage chemotaxis, which is a crucial step for the development of atherosclerosis, was also inhibited in vitro by THC. All these effects were completely blocked by a specific CB2 receptor antagonist. Our data demonstrate that oral treatment with a low dose of THC inhibits atherosclerosis progression in the apolipoprotein E knockout mouse model, through pleiotropic immunomodulatory effects on lymphoid and myeloid cells. Thus, THC or cannabinoids with activity at the CB2 receptor may be valuable targets for treating atherosclerosis.     

β沸石的相对结晶度和Na2O含量对FCC催化剂催化性能的影响

β沸石的相对结晶度和Na2 O含量对引入 β沸石的FCC催化剂的催化性能有一定的影响。催化剂在 780℃下经 10 0 %水蒸气处理 4h后 ,影响FCC催化剂催化作用的主要因素是 β沸石的相对结晶度 ,Na2 O含量对催化剂初活性的影响不显著。催化剂在 780℃经 10 0 %水蒸气处理 17h后 ,β沸石的Na2 O含量对分子筛骨架稳定性的作用增大 ,从而导致引入高Na2 O含量的 β沸石的FCC催化剂的微反活性比低Na2 O含量样品的活性有所下降 ,同时使低碳烯烃和异构烷烃的产率降低。因此 ,引入FCC催化剂的 β沸石的相对结晶度要大于 80 % ,并要求其Na2 O含量低于 0 .1%。     

基于NFS的UNIX与Netware间数据传送

文中介绍在UNIX多用户系统与Novell网络服务器建立网络互连情况下 ,应用网络文件系统NFS使UNIX系统主机与Novell网络服务器之间实现数据的互备份。     

PLC实验装置的研制

介绍了PLC实验装置研制的意义 ,给出了实验装置的构成、功能、原理、特点以及可完成的培训内容。     

基于GA和粗集结合的规则抽取方法研究

本文介绍了一种基于GA和粗集结合的规则抽取方法。该方法可在具有不确定、不一致和不完备的大型数据库中进行规则抽取 ,并使用了一种二进制的分辨矩阵以寻找简式。不一致性问题通过上下近似来解决 ;不确定性和不完备性问题通过修改对象间的可分辨性到粗可分辨性的定义来处理。通过一个例子来说明该方法 ,且结果显示该方法是有效的。     

纳米润滑材料的研究及其在石油管连接中应用展望

阐述了纳米粒子的摩擦学研究进展 ,综合了纳米粒子在基础油中的分散与纳米润滑材料的抗磨减摩机理 .针对目前现场石油井油管扣和套管扣使用的丝扣油存在的缺陷 ,在现有丝扣油中通过加入纳米微粒作为润滑添加剂 ,以期减小上、卸扣劳动强度和避免咬扣、粘扣事故发生     

高负压吸引治疗慢性化脓性中耳炎40例

目的：观察高负压吸引法治疗慢性化脓性中耳炎的疗效。方法：选择经常规治疗方法难以干耳的慢性单纯性中耳炎40例(46耳)，采用高负压吸引法进行治疗。结果：治愈43耳，其中8耳仅治疗一次即愈，治愈率为93．5％。结论：高负压吸引法是治疗难治性慢性单纯性中耳炎有效、安全的首选方法，值得推广。     

Effect of glucagon on ethanol oxidation in isolated rat liver cells

Summary Addition of glucagon 5 min after ethanol was found to stimulate the rate of ethanol oxidation in hepatocytes isolated from starved rats. This stimulation is of the same order of magnitude as that mediated by asparagine. The glucagon effect is suppressed by antiproteolytic agents such as insulin or NH₄Cl. The stimulatingeffect of glucagon on ethanol oxidation is probably liked to enhanced proteolysis andan elevated glutamate level in the hepatocytes.Acknowledgments. this investigation was supported by grants from the Institut de la Santé de la Recherche Médicale, the Scientific Council of the Faculté de Médecine Paris-Ouest and the Ecole Pratique des Hautes Etudes (3rd section).     

以沥青为原料制备油井高温防砂剂

以沥青中的稠环芳烃为原料的改性 COPNA树脂可用作高温防砂材料 ,该材料具有原材料易得、价廉 ,且在高温下 ( 4 0 0～ 5 0 0℃ )长期不分解 ,抗压强度高等特点 .根据 COPNA树脂的溶解性及热稳定性实验结果阐述了改性 COPNA树脂作为防砂剂的优点 ,并对以胜利 1 0 0号沥青为原料合成的改性 COPNA树脂的性能进行了试验研究