Lead distribution in the nervous system of 8-month-old rats intoxicated since birth by lead

Lead levels in the nervous system of rats intoxicated for 8 months by lead acetate (0.2% in drinking water) varied according to the region: the lowest levels were observed in sciatic nerve and the highest in hippocampus and cerebral neocortex, while intermediate levels were observed in pons medulla, cerebellum, midbrain, hypothalamus and striatum.     

The addition of ethyl azodicarboxylate to pyrroles

Zusammenfassung Es reagieren die - und -Positionen von Pyrrol-Derivaten ohne weiteres mit thyl-Azodicarboxylat unter Bildung von Hydrazindicarboxyester-Derivaten, was durch die NMR- und IR-Spektren bestätigt wird.     

Agglutinating antibrain antibodies in dogs with experimental allergic encephalomyelitis

Résumé Chez 19 chiens présentant des symptomes de EAE, on a trouvé des anticorps sériques anticerveaux pendant divers laps de temps.     

Defect of incorporation of S in old Swan autoimmune mice thymus (author's transl)]

A diminution of the incorporation of radioactive S in epithelial cells of the thymus of auto-immune Swan mice is shown. This defect of incorporation seems to be in relation to a thymus deficiency.     

Occurrence in mushrooms (Homobasidiomycetes) of cis- and trans-octa-1,5-dien-3-ol,attractants to the cheese miteTyrophagus putrescentiae (Schrank) (Acarina,Acaridae)

Summary Cis- and trans-octa-1,5-dien-3-ol were identified in 15 Homobasidiomycetes; these compounds exhibited a significant attraction for the cheese miteTyrophagus putrescentiae (Schrank) (Acarina, Acaridae).     

The role of ras and other low molecular weight guanine nucleotide (GTP)-binding proteins during hematopoietic cell differentiation

Recent progress in the understanding of signal transduction and gene regulation in hematopoietic cells has shown that many intracellular signalling pathways are modulated by low molecular weight guanine nucleotide (GTP)-binding proteins (LMWGs). LMWGs act as molecular switches for regulating a wide range of signal-transduction pathways in virtually all cells. In hematopoietic cells, LMWGs have been shown to participate in essential functions such as growth control, differentiation, cytoskeletal organization, cytokine and chemoattractant-induced signalling events, reduced nicotinamide adenine dinucleotide phosphate oxidase activity, intracellular vesicle transport and secretion. In human leukemias, myelodysplastic syndromes and myeloproliferative disorders, Ras activation occurs by point mutations, overexpression or by alteration of NF-1 Ras-GTPase activating protein (GAP). These are postinitiation events in leukemia but may modulate growth-factor-dependent and independent leukemic growth. Two animal models of mutated N-ras expression resulting in myelodysplastic and myeloproliferative features are discussed. The role of Ras in organ development is discussed in the context of transgenic knockout mice. More LMWG functions will certainly be identified as we gain a better understanding of regulatory pathways modulating myeloid signal transduction. This review will summarize our current understanding of this rapidly advancing area of research.