高耸结构建造阶段环境振动测试与模态分析

以建造阶段的广州新电视塔为研究背景,详细介绍了在一般风荷载激励下,对其进行的一次环境振动测试,然后用频域法和时域法两种不同的方法识别出了在测试阶段电视塔的前十阶模态频率及相应的振型和阻尼比,并与SAP2000有限元模型的计算结果进行了比较。结果表明本次频率的测试值和理论值低阶模态频率符合得很好,但高阶存在一定的差异。表明此次环境振动测试结果可以用来修正电视塔的初始有限元模型,从而为今后的健康监测和损伤检测提供较精确的基准模型。     

Simple scaling relations in geodynamics： the role of pressure in mantle convection and plume formation

Scaling relations are important in extrapolating laboratory experiments to the Earth‘s mantle. In planetary interiors, compression becomes an important parameter and it is useful to explore scalings that involve volume. I use simple volume scaling relations that allow one to extrapolate laboratory experiments and upper mantle behavior, in a thermodynamically self-consistent way, to predict lower mantle behavior. The relations are similar to the quasi-har-monic approximation. Slabs and plates have characteristic dimensions of hundreds of kilometers and time constants of 100 million years, but the volume scalings predict order of magnitude higher values in the deep mantle. The scaling relations imply that the deep mantle is a sluggish system with ancient features. They imply irreversible chemical stratification and do not favor the plume hypothesis.     

Subtractive proteomic mapping of the endothelial surface in lung and solid tumours for tissue-specific therapy

The molecular complexity of tissues and the inaccessibility of most cells within a tissue limit the discovery of key targets for tissue-specific delivery of therapeutic and imaging agents in vivo. Here, we describe a hypothesis-driven, systems biology approach to identifying a small subset of proteins induced at the tissue-blood interface that are inherently accessible to antibodies injected intravenously. We use subcellular fractionation, subtractive proteomics and bioinformatics to identify endothelial cell surface proteins exhibiting restricted tissue distribution and apparent tissue modulation. Expression profiling and gamma-scintigraphic imaging with antibodies establishes two of these proteins, aminopeptidase-P and annexin A1, as selective in vivo targets for antibodies in lungs and solid tumours, respectively. Radio-immunotherapy to annexin A1 destroys tumours and increases animal survival. This analytical strategy can map tissue- and disease-specific expression of endothelial cell surface proteins to uncover novel accessible targets useful for imaging and therapy.