Zwei neue Sesquiterpene mit Isosativangerüst ausHelminthosporium sativum

Summary The structure of two new sesquiterpene metabolites ofHelminthosporium sativum, previously assigned to the sativene series, has been settled as in4 and14 by chemical correlation.     

粒子和核——物理概念导论

本书从实验角度统一地描述了原子核和基本粒子，是作者们基于在海德堡大学给大学三年级学生讲授原子核与基本粒子课的讲义基础上发展成书的。其第一版于1995年出版，1999年和2002年出版了两次修订版。本书是2004年出版的第四版。本版主要的修改是增加了中微子振荡和无中微子双β衰变等最新实验进展的介绍。     

Stochastic Factors Affecting the Diffusion of A Technological Inndovation-A

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(S)-3-p-Methoxyphenyl-3-acetylaminopropan-1-ol, a New Metabolite of an Actinomycete.

(S)-3-p-methoxyphenyl-3-acetamidopropan-1-ol was isolated from cultures of an actinomycete (Streptomyces michiganensis). Its structural determination by spectroscopic means and its synthesis are described.     

Insulin stimulates sodium-potassium activated ATPase from rat hippocampus

Summary It is suggested that insulin is capable of activating cerebral NaK-ATPase in a dose-dependent manner.Supported by grants from Ministerium für Hoch- und Fachschulwesen der DDR.     

自动温度记录技术在斑尾榛鸡产卵孵卵节律研究中的应用

以莲花山斑尾榛鸡(Bonasa sewerzowi)的研究结果为例,介绍了利用自动温度记录器技术研究鸟类产卵孵卵节律的方法.研究表明,斑尾榛鸡雌鸟每隔2d产1枚卵,通过分析1只斑尾榛鸡雌鸟整个孵卵期的孵卵节律,发现它平均每天出巢(5.55±0.80)次(4～7次,n=22),平均每次出巢时间为(17.6±6.77)min.雌鸟早晨出巢的时刻平均为6:07±23min,傍晚出巢的回巢时刻平均为19:40±22min,日活动期平均为(812.5±35.1)min.雌鸟出巢的时间长度与环境温度呈正相关(Spearman相关检验,r=0.264,p=0.004),说明斑尾榛鸡在较温暖的天气条件下出巢时间较长.     

Deficiency of UBR1, a ubiquitin ligase of the N-end rule pathway, causes pancreatic dysfunction, malformations and mental retardation (Johanson-Blizzard syndrome)

Johanson-Blizzard syndrome (OMIM 243800) is an autosomal recessive disorder that includes congenital exocrine pancreatic insufficiency, multiple malformations such as nasal wing aplasia, and frequent mental retardation. We mapped the disease-associated locus to chromosome 15q14-21.1 and identified mutations, mostly truncating ones, in the gene UBR1 in 12 unrelated families with Johanson-Blizzard syndrome. UBR1 encodes one of at least four functionally overlapping E3 ubiquitin ligases of the N-end rule pathway, a conserved proteolytic system whose substrates include proteins with destabilizing N-terminal residues. Pancreas of individuals with Johanson-Blizzard syndrome did not express UBR1 and had intrauterine-onset destructive pancreatitis. In addition, we found that Ubr1(-/-) mice, whose previously reported phenotypes include reduced weight and behavioral abnormalities, had an exocrine pancreatic insufficiency, with impaired stimulus-secretion coupling and increased susceptibility to pancreatic injury. Our findings indicate that deficiency of UBR1 perturbs the pancreas' acinar cells and other organs, presumably owing to metabolic stabilization of specific substrates of the N-end rule pathway.     

Über die Beeinflussung der Ca-Aufnahme in Lipidextrakte aus Mikrosomen und Mitochondrien des Herzens durch Digitoxin

Summary Lipids were isolated by chloroform-methanol extraction from mitochondrial and microsomal fractions of guinea-pig hearts. In the presence of digitoxin (10^–9-10^–6 g/ml) 15–30% more radioactive Ca was taken up by the lipid extracts than under control conditions, but the total amount of Ca in this phase remained unchanged. Thus, digitoxin produced an increase in the specific activity of the lipid-bound Ca which may be explained by an increased exchangeability of this Ca fraction. This effect of digitoxin might result in an improved availability of the lipid-bound Ca for Ca-dependent functions (e.g. contraction) of the heart muscle cell.