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211.
In nature, helical macromolecules such as collagen, chitin and cellulose are critical to the morphogenesis and functionality of various hierarchically structured materials. During tissue formation, these chiral macromolecules are secreted and undergo self-templating assembly, a process whereby multiple kinetic factors influence the assembly of the incoming building blocks to produce non-equilibrium structures. A single macromolecule can form diverse functional structures when self-templated under different conditions. Collagen type I, for instance, forms transparent corneal tissues from orthogonally aligned nematic fibres, distinctively coloured skin tissues from cholesteric phase fibre bundles, and mineralized tissues from hierarchically organized fibres. Nature's self-templated materials surpass the functional and structural complexity achievable by current top-down and bottom-up fabrication methods. However, self-templating has not been thoroughly explored for engineering synthetic materials. Here we demonstrate the biomimetic, self-templating assembly of chiral colloidal particles (M13 phage) into functional materials. A single-step process produces long-range-ordered, supramolecular films showing multiple levels of hierarchical organization and helical twist. Three distinct supramolecular structures are created by this approach: nematic orthogonal twists, cholesteric helical ribbons and smectic helicolidal nanofilaments. Both chiral liquid crystalline phase transitions and competing interfacial forces at the interface are found to be critical factors in determining the morphology of the templated structures during assembly. The resulting materials show distinctive optical and photonic properties, functioning as chiral reflector/filters and structural colour matrices. In addition, M13 phages with genetically incorporated bioactive peptide ligands direct both soft and hard tissue growth in a hierarchically organized manner. Our assembly approach provides insight into the complexities of hierarchical assembly in nature and could be expanded to other chiral molecules to engineer sophisticated functional helical-twisted structures. 相似文献
212.
Bonnin A Goeden N Chen K Wilson ML King J Shih JC Blakely RD Deneris ES Levitt P 《Nature》2011,472(7343):347-350
Serotonin (5-hydroxytryptamine or 5-HT) is thought to regulate neurodevelopmental processes through maternal-fetal interactions that have long-term mental health implications. It is thought that beyond fetal 5-HT neurons there are significant maternal contributions to fetal 5-HT during pregnancy but this has not been tested empirically. To examine putative central and peripheral sources of embryonic brain 5-HT, we used Pet1(-/-) (also called Fev) mice in which most dorsal raphe neurons lack 5-HT. We detected previously unknown differences in accumulation of 5-HT between the forebrain and hindbrain during early and late fetal stages, through an exogenous source of 5-HT which is not of maternal origin. Using additional genetic strategies, a new technology for studying placental biology ex vivo and direct manipulation of placental neosynthesis, we investigated the nature of this exogenous source. We uncovered a placental 5-HT synthetic pathway from a maternal tryptophan precursor in both mice and humans. This study reveals a new, direct role for placental metabolic pathways in modulating fetal brain development and indicates that maternal-placental-fetal interactions could underlie the pronounced impact of 5-HT on long-lasting mental health outcomes. 相似文献
213.
Mills RE Walter K Stewart C Handsaker RE Chen K Alkan C Abyzov A Yoon SC Ye K Cheetham RK Chinwalla A Conrad DF Fu Y Grubert F Hajirasouliha I Hormozdiari F Iakoucheva LM Iqbal Z Kang S Kidd JM Konkel MK Korn J Khurana E Kural D Lam HY Leng J Li R Li Y Lin CY Luo R Mu XJ Nemesh J Peckham HE Rausch T Scally A Shi X Stromberg MP Stütz AM Urban AE Walker JA Wu J Zhang Y Zhang ZD Batzer MA Ding L Marth GT McVean G Sebat J Snyder M Wang J Ye K Eichler EE Gerstein MB Hurles ME Lee C McCarroll SA 《Nature》2011,470(7332):59-65
Genomic structural variants (SVs) are abundant in humans, differing from other forms of variation in extent, origin and functional impact. Despite progress in SV characterization, the nucleotide resolution architecture of most SVs remains unknown. We constructed a map of unbalanced SVs (that is, copy number variants) based on whole genome DNA sequencing data from 185 human genomes, integrating evidence from complementary SV discovery approaches with extensive experimental validations. Our map encompassed 22,025 deletions and 6,000 additional SVs, including insertions and tandem duplications. Most SVs (53%) were mapped to nucleotide resolution, which facilitated analysing their origin and functional impact. We examined numerous whole and partial gene deletions with a genotyping approach and observed a depletion of gene disruptions amongst high frequency deletions. Furthermore, we observed differences in the size spectra of SVs originating from distinct formation mechanisms, and constructed a map of SV hotspots formed by common mechanisms. Our analytical framework and SV map serves as a resource for sequencing-based association studies. 相似文献
214.
澳大利亚和新西兰都是英语国家且在文化和经济上历来与英国和美国有着紧密的联系,同时他们又都是依靠资源和农业的传统型经济体.最近的一篇关于新西兰创新体制的OECD报告中提到这样一段话:“过去,新西兰经济主要是依靠农业、林业、渔业、加工及服务业而发展的典型的自然资源经济.而近年来随着农业食品生物技术、旅游业以及影视制作等新兴... 相似文献
215.
Suppression of inflammation by a synthetic histone mimic 总被引:1,自引:0,他引:1
Nicodeme E Jeffrey KL Schaefer U Beinke S Dewell S Chung CW Chandwani R Marazzi I Wilson P Coste H White J Kirilovsky J Rice CM Lora JM Prinjha RK Lee K Tarakhovsky A 《Nature》2010,468(7327):1119-1123
216.
Hyerim Han Sang Hyeon Koh Bo Young Han Yeong Jin Chung Sang Chul Shin 《南京林业大学学报(自然科学版)》2010,34(4):175-175
以往研究认为,2006年前在韩国唯一的传播松材线虫的天牛是松褐天牛,但是最近的研究发现云杉花墨天牛也能传播松材线虫。对于两种天牛携带和传播线虫种类,特别是对拟松材线虫的携带和传播途径需要进一步研究。拟松材线虫分为欧洲型和东亚型,在韩国两种生物型都存在。笔者的研究表明大部分云杉花墨天牛携带的是欧洲型的拟松材线虫。 相似文献
217.
Metallorganic chemical vapor deposition is used as a novel simple pore tailoring method to fine-tune the pore opening size of SBA-15 materials without significant loss in pore volume and surface area. By using acetylene as carbon source and copper (II) acetylacetonate as precursor, the poremouth of SBA-15 is effectively reduced from 5.78 nm to 3.67 nm while maintaining the pore body at 5.78 nm. The effect of four pore modification factors-the ratio of acetylene/nitrogen, the feeding time of carbon precursor, the ratio of SBA-C/Cu(acac)2 and the cycles of MOCVD on the final pore structure of the SBA-15/carbon/copper composite is studied. The morphology and microstructure of the resulting product SBA-C-Cu are characterized by XRD patterns, TEM images and EDS analysis. The XRD and TEM reveal that the SBA-C-Cu composite is highly hexagonally ordered and has similar particle morphology as the original SBA-15. 相似文献
218.
Vinko SM Ciricosta O Cho BI Engelhorn K Chung HK Brown CR Burian T Chalupský J Falcone RW Graves C Hájková V Higginbotham A Juha L Krzywinski J Lee HJ Messerschmidt M Murphy CD Ping Y Scherz A Schlotter W Toleikis S Turner JJ Vysin L Wang T Wu B Zastrau U Zhu D Lee RW Heimann PA Nagler B Wark JS 《Nature》2012,482(7383):59-62
Matter with a high energy density (>10(5)?joules per cm(3)) is prevalent throughout the Universe, being present in all types of stars and towards the centre of the giant planets; it is also relevant for inertial confinement fusion. Its thermodynamic and transport properties are challenging to measure, requiring the creation of sufficiently long-lived samples at homogeneous temperatures and densities. With the advent of the Linac Coherent Light Source (LCLS) X-ray laser, high-intensity radiation (>10(17)?watts per cm(2), previously the domain of optical lasers) can be produced at X-ray wavelengths. The interaction of single atoms with such intense X-rays has recently been investigated. An understanding of the contrasting case of intense X-ray interaction with dense systems is important from a fundamental viewpoint and for applications. Here we report the experimental creation of a solid-density plasma at temperatures in excess of 10(6) kelvin on inertial-confinement timescales using an X-ray free-electron laser. We discuss the pertinent physics of the intense X-ray-matter interactions, and illustrate the importance of electron-ion collisions. Detailed simulations of the interaction process conducted with a radiative-collisional code show good qualitative agreement with the experimental results. We obtain insights into the evolution of the charge state distribution of the system, the electron density and temperature, and the timescales of collisional processes. Our results should inform future high-intensity X-ray experiments involving dense samples, such as X-ray diffractive imaging of biological systems, material science investigations, and the study of matter in extreme conditions. 相似文献
219.
220.
Dye-sensitized solar cells based on titanium dioxide (TiO(2)) are promising low-cost alternatives to conventional solid-state photovoltaic devices based on materials such as Si, CdTe and CuIn(1-x)Ga(x)Se(2) (refs 1, 2). Despite offering relatively high conversion efficiencies for solar energy, typical dye-sensitized solar cells suffer from durability problems that result from their use of organic liquid electrolytes containing the iodide/tri-iodide redox couple, which causes serious problems such as electrode corrosion and electrolyte leakage. Replacements for iodine-based liquid electrolytes have been extensively studied, but the efficiencies of the resulting devices remain low. Here we show that the solution-processable p-type direct bandgap semiconductor CsSnI(3) can be used for hole conduction in lieu of a liquid electrolyte. The resulting solid-state dye-sensitized solar cells consist of CsSnI(2.95)F(0.05) doped with SnF(2), nanoporous TiO(2) and the dye N719, and show conversion efficiencies of up to 10.2 per cent (8.51 per cent with a mask). With a bandgap of 1.3 electronvolts, CsSnI(3) enhances visible light absorption on the red side of the spectrum to outperform the typical dye-sensitized solar cells in this spectral region. 相似文献