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51.
N. Akaike K. Hattori Y. Oomura D. O. Carpenter 《Cellular and molecular life sciences : CMLS》1985,41(1):70-71
Summary Using isolated, internally perfused bullfrog dorsal root ganglion cells we have studied the dose-response curves for -aminobutyric acid (GABA) in the presence of internally or externally applied GABA antagonists. With external application of antagonists the inhibition of the GABA current by bicuculline was competitive and that by picrotoxin was noncompetitive. Picrotoxin but not bicuculline blocked when internally perfused.To whom reprint requests should be addressed.Acknowledgments. We thank Drs S. Minakami and S. Yasui for helpful discussions and comments. 相似文献
52.
53.
R. K. A. Giger H. R. Loosli M. D. Walkinshaw B. J. Clark J. M. Vigouret 《Cellular and molecular life sciences : CMLS》1987,43(10):1125-1130
Summary We report the synthesis, stereochemistry and preliminary pharmacological evaluation of DCN 203-922, a novel ergot alkaloid of the cyclol type, which contains in its peptide moiety the uncommon amino acid L-allo-isoleucine.Part of this paper was reported by this author at the Herbstversammlung der Schweizerischen Chemischen Gesellschaft, Bern, in October 1986. 相似文献
54.
Chromosomal localization of human haemoglobin structural genes 总被引:15,自引:0,他引:15
55.
MSI and MSII made on ribosome in idling step of protein synthesis 总被引:56,自引:0,他引:56
56.
Growth of the bacterial cell 总被引:56,自引:0,他引:56
57.
RNA-DNA hybrids at the cytological level 总被引:37,自引:0,他引:37
58.
Summary The biochemical development of the fetal brain in relation to maternal vitamin A restriction was studied in rats. The vitamin A status of pregnant rats was varied by supplying low, medium and adequate amounts (6, 40, and 100 g retinol/day/kg body weight, respectively) of vitamin A during pregnancy and suckling. The maternal vitamin A restriction caused an altered brain development in terms of tissue weight, DNA, RNA and protein levels, and biosynthesis of DNA and protein from [3H]-thymidine and [3H]-leucine, respectively. A dose-dependent effect of maternal vitamin A restriction on the metabolism of DNA, RNA and protein was noticed in the developing fetal brain of rats. 相似文献
59.
Hypothalamic histamine modulates adaptive behavior of rats at high environmental temperature 总被引:1,自引:0,他引:1
K. Fujimoto T. Sakata K. Ookuma M. Kurokawa A. Yamatodani H. Wada 《Cellular and molecular life sciences : CMLS》1990,46(3):283-285
Summary Histamine content in the rat hypothalamus was lower at 4°C and higher at 31°C compared to that at 21°C. Pretreatment with -fluoromethylhistidine, a suicide inhibitor of histidine decarboxylase, attenuated both the increased level of hypothalamic histamine and rat adaptive behavior at 31°C. Increase of histamine content in the hypothalamus appears to be an important factor contributing to rat adaptive behavior to high environmental temperature. 相似文献
60.
A. Rakovska K. Milenov P. Henklein 《Cellular and molecular life sciences : CMLS》1990,46(10):1037-1041
Summary Suc-Tyr-(SE)-Met-Gly-Trp-Met-Asp--phenethylamide (GE 410) competitively antagonized the contractions of smooth muscle strips from guinea pig ileum (pA2=7.6, n=0.95) induced by cholecystokinin-octapeptide (CCK8). GE 410 inhibited the electrically-induced cholinergically mediated contractile responses and the [3H]ACh release in the ileum, as well as the CCK-stimulated electrical contractile responses and the [3H]ACh release in the cholinergic nerve terminals. The results suggest the existence of CCK-receptors not only in the smooth muscles but also on the neurons. 相似文献