A role for mitochondria in NLRP3 inflammasome activation

An inflammatory response initiated by the NLRP3 inflammasome is triggered by a variety of situations of host 'danger', including infection and metabolic dysregulation. Previous studies suggested that NLRP3 inflammasome activity is negatively regulated by autophagy and positively regulated by reactive oxygen species (ROS) derived from an uncharacterized organelle. Here we show that mitophagy/autophagy blockade leads to the accumulation of damaged, ROS-generating mitochondria, and this in turn activates the NLRP3 inflammasome. Resting NLRP3 localizes to endoplasmic reticulum structures, whereas on inflammasome activation both NLRP3 and its adaptor ASC redistribute to the perinuclear space where they co-localize with endoplasmic reticulum and mitochondria organelle clusters. Notably, both ROS generation and inflammasome activation are suppressed when mitochondrial activity is dysregulated by inhibition of the voltage-dependent anion channel. This indicates that NLRP3 inflammasome senses mitochondrial dysfunction and may explain the frequent association of mitochondrial damage with inflammatory diseases.     

纤维对PEI改性环氧树脂单向复合材料形态的影响

人们改善环氧树脂基复合材料的脆性通常只改善环氧树脂基体和增强纤维间的界面，提高环氧树脂韧性的另一种常用方法是添加初始相容性良好的热塑性树脂如聚醚酰亚胺，在某一转化率（取决于体系的组成和反应温度）时体系发生相转变，体系最终的形态由相转变速率和环氧树脂反应速度所控制。本文作者研究了两种增强纤维（玻璃纤维和碳纤维）对不同环氧树脂／聚醚酰亚爱体系形态形成的影响，结果发现体系中纤维的存在不会影响基体相分离过程，但会改变体系的最终形态；形态的变化与纤维的品种关系不大；基体中不同组分的粘度是影响复合材料形态形成的关键因素。     

Advances and applications of electrohydrodynamics

Electrohydrodynamics (EHD) has been applied in many areas, such as EHD enhanced heat transfer, EHD pump, electrospray mass spectrometry, electrospray nanotechnology, etc. The basic theories underlying these applications and a brief review of the EHD advances are presented in this paper. As electrospray is an important branch of EHD,the applications of electrospray are particularly discussed.Finally, this paper gives some suggestions for the future research and development.     

Design and fabrication of 1-D semiconductor nanomaterials for high-performance photovoltaics

To date, the cost-effective utilization of solar energy by photovoltaics for large-scale deployment remains challenging. Further cost minimization and efficiency maximization, through reduction of material consumption, simplification of device fabrication as well as optimization of device structure and geometry, are required. The usage of 1D nanomaterials is attractive due to the outstanding light coupling effect, the ease of fabrication, and integration with one-dimensional(1-D) semiconductor materials. The light absorption efficiency can be enhanced significantly, and the corresponding light-toelectricity conversion efficiency can be as high as their bulk counterparts. Also, the amount of active materials used can be reduced. This review summarizes the recent development of 1-D nanomaterials for photovoltaic applications, including the anti-reflection, the light absorption,the minority diffusion, and the semiconductor junction properties. With solid progress and prospect shown in the past 10 years, 1-D semiconductor nanomaterials are attractive and promising for the realization of high-efficiency and low-cost solar cells.     

1800mm虚拟轧机板形控制性能

定义了评价轧机板形控制性能的六项指标,包括承载辊缝凸度调节域、辊缝横向刚度、板形调控功效曲线、边缘降、辊间接触压力平均幅值和辊间接触压力分布不均匀度.建立了HC,CVC,PC和DSR系列轧机的有限元仿真模型,并从板形控制性能的六项指标方面分析了当前国际上流行的各种机型的特点.     

云南保山盆地生物气源岩生物标志化合物特征

通过对保山盆地气源岩有机质饱和烃色谱、三环萜烷、四环萜烷、五环三萜烷及甾烷分布特征的研究,发现气源岩有机质碳数分布存在比较明显的奇碳优势,结合R.数据,认为该区气源岩成熟度很低;可溶有机质生物标志化合物中的三环萜烷、四环萜烷含量低,五环三萜烷中有含量十分丰富的生物藿烷,表明源岩成熟度低;还检测出与细菌作用有关的C<,3...     

BP神经网络在入侵检测中的应用

对如何检测未知入侵手段的问题进行了探讨．在被监测程序输入条件已知情况下，借助程序行为简档，给出了一种基于BP神经网络的入侵检测方法，阐述了所用BP神经网络的基本结构以及训练方法，最后在LINUX环境下进行了实验验证．结果表明，在程序行为简档内容比较清晰的条件下，运用BP神经网络检测入侵，可在一定程度上提高入侵检测系统的难确检测率．     

超凸度量空间中的极大极小不等式和拟变分不等式

用连续迭取方法得到了超凸距离空间上集值映射的一个不动点定理。作为应用，给出了超凸距离空间中的一个极小极大定理和广义拟变分不等式解的一个存在性定理。     

基于中期基准面旋回变化的沉积微相精细研究——以松辽盆地扶余油田泉四段为例

 从区域沉积背景出发,以岩心和测井资料分析为基础,对松辽盆地扶余油田泉四段的岩石类型、粒度分布、沉积构造、泥岩颜色及地球化学特征等各类沉积相标志进行分析,确定其为三角洲沉积,包含三角洲平原和前缘亚相。其中,平原亚相可识别出分支河道、决口扇、天然堤、废弃河道、湖泊沼泽微相;前缘亚相可细分为水下分支河道、河口坝、远沙坝、水下天然堤和支流间湾等微相。依据沉积微相与地层格架的成因关系,在中期基准面旋回的控制下应用取心关键井建立了沉积微相的定量识别图板,对非取心井进行沉积微相的定量识别与划分,并在此基础上绘制了沉积微相的平面及剖面图,总结了微相类型的平面和纵向展布规律及其与含油性的关系,指出分支河道砂体发育规模、连续性、储集性、含油性最好,其次为河口坝砂体,为研究区下一步的开发方案提供地质依据。