CCDC103 mutations cause primary ciliary dyskinesia by disrupting assembly of ciliary dynein arms

Cilia are essential for fertilization, respiratory clearance, cerebrospinal fluid circulation and establishing laterality. Cilia motility defects cause primary ciliary dyskinesia (PCD, MIM244400), a disorder affecting 1:15,000-30,000 births. Cilia motility requires the assembly of multisubunit dynein arms that drive ciliary bending. Despite progress in understanding the genetic basis of PCD, mutations remain to be identified for several PCD-linked loci. Here we show that the zebrafish cilia paralysis mutant schmalhans (smh(tn222)) encodes the coiled-coil domain containing 103 protein (Ccdc103), a foxj1a-regulated gene product. Screening 146 unrelated PCD families identified individuals in six families with reduced outer dynein arms who carried mutations in CCDC103. Dynein arm assembly in smh mutant zebrafish was rescued by wild-type but not mutant human CCDC103. Chlamydomonas Ccdc103/Pr46b functions as a tightly bound, axoneme-associated protein. These results identify Ccdc103 as a dynein arm attachment factor that causes primary ciliary dyskinesia when mutated.     

Forecasting regional house price inflation: a comparison between dynamic factor models and vector autoregressive models

This paper uses the dynamic factor model framework, which accommodates a large cross‐section of macroeconomic time series, for forecasting regional house price inflation. In this study, we forecast house price inflation for five metropolitan areas of South Africa using principal components obtained from 282 quarterly macroeconomic time series in the period 1980:1 to 2006:4. The results, based on the root mean square errors of one to four quarters ahead out‐of‐sample forecasts over the period 2001:1 to 2006:4 indicate that, in the majority of the cases, the Dynamic Factor Model statistically outperforms the vector autoregressive models, using both the classical and the Bayesian treatments. We also consider spatial and non‐spatial specifications. Our results indicate that macroeconomic fundamentals in forecasting house price inflation are important. Copyright © 2010 John Wiley & Sons, Ltd.     

基于粒子群算法的非规则LDPC码度序列设计

研究了非规则低密度奇偶校验（low-density parity-check, LDPC）码度序列阈值计算方法，详细讨论了构造具有较高阈值度序列的步骤与约束条件的处理，提出了一种基于粒子群优化（particle swarm optimization, PSO）算法的度序列优化方法。仿真了此方法的寻优效果，给出了一些接近Shannon限的优秀度序列和分析比较。     

对提高植物新品种保护制度运行效率的思考

通过对我国植物新品种保护的实施情况进行分析,发现植物新品种保护并没有发挥出预期的制度效果。本文从育种者、种子产业和管理部门三个层面探讨了影响植物新品种制度运行效率的障碍因素及其原因,提出要保证植物新品种保护充分发挥其制度效果不能把目光仅放在完善品种保护体系本身,而要从推动品种权实施、规范种子产业发展和构建品种权保护机制三个方面同时入手,并给出了相应的对策建议。     

未掺杂SI-GaAs退火行为的正电子湮没研究

用正电子湮没技术,研究了未掺杂的SI-GaAs退火行为。结果表明,长寿命分量τ_2的变化不仅与镓空位而且和多镓空位络合物有关。本文还讨论了电子和中子辐照的影响。     

船舶喷水推进装置特性曲线及其计算与绘制方法

本文对船舶喷水推进装置特性曲线的形式及计算绘制方法进行了探讨,并对喷水推进装置特性曲线作了必要的分析和介绍了它的使用方法。     

灰铸铁中初生奥氏体树枝晶二维金相切面与三维空间结构之间的关系

本文应用晶体几何学原理,对灰铸铁中初生奥氏体树枝晶进行了解剖研究,发现金相试样中复杂纷乱的枝晶二维切面是不同位向的树枝晶沿一定晶面切开的结果。利用树枝晶二维和三维空间结构之间的几何对应关系,可以比较方便、准确地对树枝晶的生长方式及形貌特征进行分析和计算。