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21.
Irena Crnković-Mertens Julia Bulkescher Christina Mensger Felix Hoppe-Seyler Karin Hoppe-Seyler 《Cellular and molecular life sciences : CMLS》2010,67(11):1895-1905
Livin (ML-IAP) is a cancer-associated member of the inhibitor of apoptosis protein (IAP) family. By yeast two-hybrid screening
of a randomized peptide expression library, we isolated short linear peptides that specifically bind to Livin, but not to
other IAPs. Intracellular expression of the peptides sensitized livin-expressing cancer cells toward different pro-apoptotic stimuli. The bioactive peptides neither showed sequence homologies
to Smac-derived IAP inhibitors, nor did they interfere with the binding of Livin to Smac. Intracellular expression of the
peptides did not affect the levels or the subcellular distribution of Livin. Growth of livin-expressing tumor cells was inhibited in colony formation assays by the Livin-targeting peptides. These findings provide evidence
that the targeted inhibition of Livin by peptides represents a viable approach for the apoptotic sensitization and growth
inhibition of tumor cells. The inhibitory peptides isolated here could form a novel basis for the development of therapeutically
useful Livin inhibitors. 相似文献
22.
Hunt KA Smyth DJ Balschun T Ban M Mistry V Ahmad T Anand V Barrett JC Bhaw-Rosun L Bockett NA Brand OJ Brouwer E Concannon P Cooper JD Dias KR van Diemen CC Dubois PC Edkins S Fölster-Holst R Fransen K Glass DN Heap GA Hofmann S Huizinga TW Hunt S Langford C Lee J Mansfield J Marrosu MG Mathew CG Mein CA Müller-Quernheim J Nutland S Onengut-Gumuscu S Ouwehand W Pearce K Prescott NJ Posthumus MD Potter S Rosati G Sambrook J Satsangi J Schreiber S Shtir C Simmonds MJ Sudman M Thompson SD Toes R 《Nature genetics》2012,44(1):3-5
23.
Finberg KE Heeney MM Campagna DR Aydinok Y Pearson HA Hartman KR Mayo MM Samuel SM Strouse JJ Markianos K Andrews NC Fleming MD 《Nature genetics》2008,40(5):569-571
Iron deficiency is usually attributed to chronic blood loss or inadequate dietary intake. Here, we show that iron deficiency anemia refractory to oral iron therapy can be caused by germline mutations in TMPRSS6, which encodes a type II transmembrane serine protease produced by the liver that regulates the expression of the systemic iron regulatory hormone hepcidin. These findings demonstrate that TMPRSS6 is essential for normal systemic iron homeostasis in humans. 相似文献
24.
NAK is an IkappaB kinase-activating kinase 总被引:13,自引:0,他引:13
Tojima Y Fujimoto A Delhase M Chen Y Hatakeyama S Nakayama K Kaneko Y Nimura Y Motoyama N Ikeda K Karin M Nakanishi M 《Nature》2000,404(6779):778-782
25.
Jonny Geidne Karin Fr?ding Stig Montin Charli Eriksson 《Systemic Practice and Action Research》2012,25(4):305-322
The last decades have seen the emergence of the settings approach in Health Promotion one example is the Healthy City initiative which was launched by European division of WHO in 1990. In 2003, four Swedish municipalities accordingly signed a contract on a Partnership for Sustainable Welfare Development. One of the objectives was to promote participation, influence, and health at a neighbourhood level by focusing on one housing area in each municipality. These housing areas constitute the setting of this study. The purpose is to examine the implementation structures in the municipalities, and how variations in the implementation structure affect differences in integration of community participation. A triangulation of methods was used in building up a case study database: semi-structured key informant interviews with 29 stakeholders in the municipalities; examination of solicited and unsolicited documents; and participatory observations which included repeated visits to the neighbourhoods. The results show that the greater the visibility of community participation policy is in the implementation structure the greater is the integration of community participation in the neighbourhood renewal work. Two explanatory factors have been identified. The first is that making the community participation policy visible in the implementation structure results in more appropriate strategies for mobilizing the community in the neighbourhood renewal work. The second is that the municipal governing of the neighbourhood renewal allows more space for community participation when the policy is visible in the implementation structure. 相似文献
26.
Timm Schubert Corinna Gleiser Peter Heiduschka Christoph Franz Kerstin Nagel-Wolfrum Ayse Sahaboglu Nicole Weisschuh Gordon Eske Karin Rohbock Norman Rieger François Paquet-Durand Bernd Wissinger Uwe Wolfrum Bernhard Hirt Wibke Singer Lukas Rüttiger Ulrike Zimmermann Marlies Knipper 《Cellular and molecular life sciences : CMLS》2015,72(20):3953-3969
27.
The human brain stands out among mammals by being unusually large. The expensive-tissue hypothesis explains its evolution by proposing a trade-off between the size of the brain and that of the digestive tract, which is smaller than expected for a primate of our body size. Although this hypothesis is widely accepted, empirical support so far has been equivocal. Here we test it in a sample of 100 mammalian species, including 23 primates, by analysing brain size and organ mass data. We found that, controlling for fat-free body mass, brain size is not negatively correlated with the mass of the digestive tract or any other expensive organ, thus refuting the expensive-tissue hypothesis. Nonetheless, consistent with the existence of energy trade-offs with brain size, we find that the size of brains and adipose depots are negatively correlated in mammals, indicating that encephalization and fat storage are compensatory strategies to buffer against starvation. However, these two strategies can be combined if fat storage does not unduly hamper locomotor efficiency. We propose that human encephalization was made possible by a combination of stabilization of energy inputs and a redirection of energy from locomotion, growth and reproduction. 相似文献
28.
29.
Lämmermann T Bader BL Monkley SJ Worbs T Wedlich-Söldner R Hirsch K Keller M Förster R Critchley DR Fässler R Sixt M 《Nature》2008,453(7191):51-55
All metazoan cells carry transmembrane receptors of the integrin family, which couple the contractile force of the actomyosin cytoskeleton to the extracellular environment. In agreement with this principle, rapidly migrating leukocytes use integrin-mediated adhesion when moving over two-dimensional surfaces. As migration on two-dimensional substrates naturally overemphasizes the role of adhesion, the contribution of integrins during three-dimensional movement of leukocytes within tissues has remained controversial. We studied the interplay between adhesive, contractile and protrusive forces during interstitial leukocyte chemotaxis in vivo and in vitro. We ablated all integrin heterodimers from murine leukocytes, and show here that functional integrins do not contribute to migration in three-dimensional environments. Instead, these cells migrate by the sole force of actin-network expansion, which promotes protrusive flowing of the leading edge. Myosin II-dependent contraction is only required on passage through narrow gaps, where a squeezing contraction of the trailing edge propels the rigid nucleus. 相似文献
30.