全文获取类型
收费全文 | 285篇 |
免费 | 0篇 |
国内免费 | 2篇 |
专业分类
系统科学 | 2篇 |
丛书文集 | 1篇 |
教育与普及 | 1篇 |
理论与方法论 | 2篇 |
现状及发展 | 57篇 |
研究方法 | 32篇 |
综合类 | 192篇 |
出版年
2020年 | 1篇 |
2018年 | 1篇 |
2017年 | 3篇 |
2016年 | 2篇 |
2015年 | 2篇 |
2014年 | 1篇 |
2012年 | 13篇 |
2011年 | 19篇 |
2010年 | 8篇 |
2009年 | 5篇 |
2008年 | 14篇 |
2007年 | 17篇 |
2006年 | 13篇 |
2005年 | 11篇 |
2004年 | 8篇 |
2003年 | 15篇 |
2002年 | 12篇 |
2001年 | 8篇 |
2000年 | 11篇 |
1999年 | 17篇 |
1998年 | 8篇 |
1997年 | 5篇 |
1996年 | 6篇 |
1995年 | 9篇 |
1994年 | 2篇 |
1992年 | 3篇 |
1991年 | 7篇 |
1990年 | 5篇 |
1989年 | 4篇 |
1988年 | 7篇 |
1987年 | 6篇 |
1986年 | 3篇 |
1985年 | 5篇 |
1984年 | 4篇 |
1983年 | 1篇 |
1981年 | 1篇 |
1980年 | 2篇 |
1979年 | 3篇 |
1978年 | 4篇 |
1976年 | 1篇 |
1975年 | 4篇 |
1974年 | 8篇 |
1973年 | 1篇 |
1972年 | 3篇 |
1966年 | 2篇 |
1965年 | 1篇 |
1960年 | 1篇 |
排序方式: 共有287条查询结果,搜索用时 109 毫秒
41.
42.
汪富明 《湖北大学学报(自然科学版)》1988,(4)
采取合理的城市规划,限制现有工厂向大气排放污染物,选择建筑物的最佳朝向和建筑气候的对策,可以在不同程度上解决武汉大气污染和室内夏热冬冷的问题。这种对策的优点是:耗资小,见效快,一劳永逸。 相似文献
43.
44.
Tumour necrosis factors alpha and beta inhibit virus replication and synergize with interferons 总被引:11,自引:0,他引:11
Tumour necrosis factor (TNF) and lymphotoxin were initially described as tumoricidal proteins that are produced by activated macrophages and lymphocytes, respectively. Since TNF and lymphotoxin are structurally related, bind to the same cell surface receptor and have indistinguishable biological activities, they have been designated as TNF-alpha and TNF-beta, respectively. The multiple activities of these molecules indicate their importance in immunoregulative responses. Here we report that both TNF-alpha and TNF-beta have antiviral activity and synergize with interferons (IFNs) in the induction of resistance to both RNA and DNA virus infection in diverse cell types. These effects of TNFs are not due to the induction of IFN synthesis. Virus-infected cells are selectively killed by TNFs and this activity is accelerated by IFN-gamma. The production of TNFs is induced by viruses, further suggesting the importance of TNFs in the physiological antiviral response. 相似文献
45.
46.
Synaptic plasticity may result from changes at existing synapses or from alterations in the number of functional synaptic connections. In the hippocampus excitatory synaptic strength is persistently enhanced after tetanic stimulation. Here we report that latent synaptic pathways may also become functional. Simultaneous intracellular recordings were made from pairs of CA3 pyramidal cells in slices from guinea pig hippocampus. After stimulating afferent fibres repetitively, polysynaptic excitatory pathways between previously unconnected cells became apparent. The efficacy of recurrent inhibitory circuits was also reduced. The loss of inhibitory control is of interest because latent excitatory pathways are revealed after pharmacological suppression of inhibition. This plasticity in local synaptic circuits leads to the emergence of synchronous firing in groups of CA3 cells. The formation of groups of associated cells and the ability of some cells to initiate synchronous firing in a larger cell group through recurrent pathways is reminiscent of several models of information storage and recall in the cortex. 相似文献
47.
P. Y. D. Wong W. M. Lee A. Y. F. Tsang 《Cellular and molecular life sciences : CMLS》1981,37(1):69-71
Summary The forward motility of the rat caudal epididymal spermatozoa has been studied in different Na+ concentrations. When spermatozoa were suspended in a completely Na+-free solution, the forward motility suffered a progressive fall and after 3 h was completely suppressed. This effect was fully reversible on resuspending the spermatozoa in a solution containing Na+. Amiloride caused a fall in motility and the effect was similar to that of Na+ removal. The inhibition by amiloride of the motility was concentration dependent and the dose response curve showed an IC50-value of about 5×10–5 M. The role of Na+ influx in the maintenance of sperm motility was discussed.This work was supported by the World Health Organization.The technical assistance of Mr C.M. Li and the gift of amiloride from Merck, Sharp and Dohme are gratefully acknowledged. 相似文献
48.
49.
Summary The effects of red and far red light on the development of the retinas were studied in the neonatal rat models. Red light appeared to be stimulatory and far red light appeared to be inhibitory. 相似文献
50.
Kinchen JM Cabello J Klingele D Wong K Feichtinger R Schnabel H Schnabel R Hengartner MO 《Nature》2005,434(7029):93-99
The removal of apoptotic cells is essential for the physiological well being of the organism. In Caenorhabditis elegans, two conserved, partially redundant genetic pathways regulate this process. In the first pathway, the proteins CED-2, CED-5 and CED-12 (mammalian homologues CrkII, Dock180 and ELMO, respectively) function to activate CED-10 (Rac1). In the second group, the candidate receptor CED-1 (CD91/LRP/SREC) probably recognizes an unknown ligand on the apoptotic cell and signals via its cytoplasmic tail to the adaptor protein CED-6 (hCED-6/GULP), whereas CED-7 (ABCA1) is thought to play a role in membrane dynamics. Molecular understanding of how the second pathway promotes engulfment of the apoptotic cell is lacking. Here, we show that CED-1, CED-6 and CED-7 are required for actin reorganization around the apoptotic cell corpse, and that CED-1 and CED-6 colocalize with each other and with actin around the dead cell. Furthermore, we find that the CED-10(Rac) GTPase acts genetically downstream of these proteins to mediate corpse removal, functionally linking the two engulfment pathways and identifying the CED-1, -6 and -7 signalling module as upstream regulators of Rac activation. 相似文献