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101.
上海地区童装购买决策行为研究 总被引:2,自引:0,他引:2
通过问卷调查,分析研究了上海童装消费者的信息来源、儿童对童装购买的影响力及童装购买决策评价因素,同时分析了收入、文化程度及儿童年龄等对相关因素的影响。 相似文献
102.
Gudbjartsson DF Arnar DO Helgadottir A Gretarsdottir S Holm H Sigurdsson A Jonasdottir A Baker A Thorleifsson G Kristjansson K Palsson A Blondal T Sulem P Backman VM Hardarson GA Palsdottir E Helgason A Sigurjonsdottir R Sverrisson JT Kostulas K Ng MC Baum L So WY Wong KS Chan JC Furie KL Greenberg SM Sale M Kelly P MacRae CA Smith EE Rosand J Hillert J Ma RC Ellinor PT Thorgeirsson G Gulcher JR Kong A Thorsteinsdottir U Stefansson K 《Nature》2007,448(7151):353-357
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in humans and is characterized by chaotic electrical activity of the atria. It affects one in ten individuals over the age of 80 years, causes significant morbidity and is an independent predictor of mortality. Recent studies have provided evidence of a genetic contribution to AF. Mutations in potassium-channel genes have been associated with familial AF but account for only a small fraction of all cases of AF. We have performed a genome-wide association scan, followed by replication studies in three populations of European descent and a Chinese population from Hong Kong and find a strong association between two sequence variants on chromosome 4q25 and AF. Here we show that about 35% of individuals of European descent have at least one of the variants and that the risk of AF increases by 1.72 and 1.39 per copy. The association with the stronger variant is replicated in the Chinese population, where it is carried by 75% of individuals and the risk of AF is increased by 1.42 per copy. A stronger association was observed in individuals with typical atrial flutter. Both variants are adjacent to PITX2, which is known to have a critical function in left-right asymmetry of the heart. 相似文献
103.
Corneo B Wendland RL Deriano L Cui X Klein IA Wong SY Arnal S Holub AJ Weller GR Pancake BA Shah S Brandt VL Meek K Roth DB 《Nature》2007,449(7161):483-486
Mammalian cells repair DNA double-strand breaks (DSBs) through either homologous recombination or non-homologous end joining (NHEJ). V(D)J recombination, a cut-and-paste mechanism for generating diversity in antigen receptors, relies on NHEJ for repairing DSBs introduced by the Rag1-Rag2 protein complex. Animals lacking any of the seven known NHEJ factors are therefore immunodeficient. Nevertheless, DSB repair is not eliminated entirely in these animals: evidence of a third mechanism, 'alternative NHEJ', appears in the form of extremely rare V(D)J junctions and a higher rate of chromosomal translocations. The paucity of these V(D)J events has suggested that alternative NHEJ contributes little to a cell's overall repair capacity, being operative only (and inefficiently) when classical NHEJ fails. Here we find that removing certain portions of murine Rag proteins reveals robust alternative NHEJ activity in NHEJ-deficient cells and some alternative joining activity even in wild-type cells. We propose a two-tier model in which the Rag proteins collaborate with NHEJ factors to preserve genomic integrity during V(D)J recombination. 相似文献
104.
不同饰面材料高强混凝土柱的耐火性能 总被引:1,自引:0,他引:1
通过对8根装饰有不同饰面材料的高强混凝土柱式构件进行ISO834标准升温条件下的明火试验,考察了饰面材料对构件表面混凝土爆裂的影响,分析了不同饰面材料高强混凝土构件的内部温度场,并与试验结果进行了对比.研究结果表明:饰面材料的引入虽然延缓了构件表面混凝土的起爆时刻,却加重了其爆裂程度;双层防火板可较好地抑制构件表面混凝土的高温爆裂;将饰面材料折算为等效混凝土的做法,总体上可较好地反映饰面材料对构件截面温度场的影响. 相似文献
105.
P Wei WW Wong JS Park EE Corcoran SG Peisajovich JJ Onuffer A Weiss WA Lim 《Nature》2012,488(7411):384-388
Bacterial pathogens have evolved specific effector proteins that, by interfacing with host kinase signalling pathways, provide a mechanism to evade immune responses during infection. Although these effectors contribute to pathogen virulence, we realized that they might also serve as valuable synthetic biology reagents for engineering cellular behaviour. Here we exploit two effector proteins, the Shigella flexneri OspF protein and Yersinia pestis YopH protein, to rewire kinase-mediated responses systematically both in yeast and mammalian immune cells. Bacterial effector proteins can be directed to inhibit specific mitogen-activated protein kinase pathways selectively in yeast by artificially targeting them to pathway-specific complexes. Moreover, we show that unique properties of the effectors generate new pathway behaviours: OspF, which irreversibly inactivates mitogen-activated protein kinases, was used to construct a synthetic feedback circuit that shows novel frequency-dependent input filtering. Finally, we show that effectors can be used in T cells, either as feedback modulators to tune the T-cell response amplitude precisely, or as an inducible pause switch that can temporarily disable T-cell activation. These studies demonstrate how pathogens could provide a rich toolkit of parts to engineer cells for therapeutic or biotechnological applications. 相似文献
106.
Xiaofeng Xia Shaoxiong Wang Jianbang Luo Ricky N. S. Wong Senfang Sui 《科学通报(英文版)》1999,44(20):1892-1892
Tianhuafen is a kind of traditional Chinese medicine for abortion, which has long been used in China. The basic protein trichosanthin (TCS) is responsible for such activity. As a ribosome inactivating protein (RIP), trichosanthin removes A4304 in the 28s rRNA via the N-glycosidase activity and inactivates the ribosome. However, it remains unclear how TCS can enter the cytoplasm. In the experiment, monolayers at air/water interface have been used to study the interaction between TCS and phospholipid membrane. The results show that TCS can penetrate negatively charged phospholipid monolayer under acid condition, and its membrane penetrating ability is obviously pH-dependent. A hypothesis of TCS penetrating biological membrane under acid condition is proposed based on the obtained result. 相似文献
107.
Directional guidance of neuronal migration in the olfactory system by the protein Slit. 总被引:34,自引:0,他引:34
Although cell migration is crucial for neural development, molecular mechanisms guiding neuronal migration have remained unclear. Here we report that the secreted protein Slit repels neuronal precursors migrating from the anterior subventricular zone in the telencephalon to the olfactory bulb. Our results provide a direct demonstration of a molecular cue whose concentration gradient guides the direction of migrating neurons. They also support a common guidance mechanism for axon projection and neuronal migration and suggest that Slit may provide a molecular tool with potential therapeutic applications in controlling and directing cell migration. 相似文献
108.
王永初 《华侨大学学报(自然科学版)》1987,(2):176-180
极值调节器是DDZ-Ⅲ型或DDZ-Ⅱ型系列仪表的一个新单元,可用于生产过程的静态最佳控制,如燃烧效率控制、蒸发器最佳液位控制,由于本调节器是由模拟线路构成,所以在模拟信号的保持,传送以及梯度方向的判断遇到某些困难,本文介绍这些问题及其解决办法。这台仪表的精度为±0.5%。 相似文献
109.
合成了通式为(C15H15N2O3)xRE(NO3)y(H2O)z(当RE=La~Pr时,x=3,y=6,z=0;RE=Nd时,x=2,y=5,z=1;RE=Sm~Lu,Y时,x=2,y=5,z=0)的一系列15种标题配合物.通过元素分析,IR,UV,1HNMR,TG-DTA,摩尔电导和X射线粉末衍射分析等对配合物的性质进行了表征.认为可能生成包含一分子水的11配位钕配合物的原因在于抗衡阳离子的空间效应,使其与络阴离子间的vanderWaals力增强的结果 相似文献
110.
YAO YingMing SHEN Qi WONG Wing Tak 《科学通报(英文版)》2007,52(4):467-470
The lanthanide coordination polymers bearing a 13-membered macrocycle, [(13-EDTA-pnOH)H2] were synthesized. The products [Ln(13-EDTA-pnOH)(H2O)2·NO3]n (Ln = Eu(1), Tb(2), Dy(3)) have been obtained by MS, IR and element analyses. The solid-state structure of 1 was established by single-crystal X-ray analysis. The coordination geometry around the central metal atom in complex 1 is a nine-coor-dinated, tricapped-trigonal prism having six donor atoms (two amine nitrogen atoms, two amide oxygen atoms and two carboxymethyl oxygen atoms) from one ligand, one oxygen atom from a neighboring ligand, and two more oxygen atoms from two water molecules. The europium atoms are linked by―Eu―O―C―O―Eu―bridges to form an infinite chain. 相似文献