Indoxyl derivatives of drug metabolites

Summary Indoxyl derivatives were detected as minor products among the urinary metabolites of two trial drugs, a benzodiazepine (GP 55 129) and a benzophenone (CGP 11 952). Their structures were elucidated by NMR and mass spectroscopy. Presumably, metabolites containing potential aldehyde functions react spontaneously with endogenous indoxyl. Such derivatives have not hitherto been encountered in drug metabolism.     

Increased assembly of cytoskeletal proteins associated with the transformation of human liver cells into fibroblast-like cells.

A topoisomerase II inhibitor, novobiocin, and a deacetylase inhibitor, butyrate, synergistically transformed human liver cells into fibroblast-like cells. This morphological change was associated with an increased production of procollagen type III peptide and a simultaneous assembly of actin, tubulin, vimentin and cytokeratin. Novobiocin and butyrate had no marked effect on the phosphorylation state of cytokeratin proteins, but synergistically enhanced [3H]acetate uptake. From these results, it can be speculated that protein acetylation plays an important role in inducing the assembly of cytoskeletal proteins and the morphological transformation of human liver cells.     

精测安培表内阻的新方法——电桥伏安法

本文提出了精测安培表内阻的新方法,并将其与其它测量方法进行了比较。     

水电工程规划设计方案的自动生成及评价

本文介绍了在水电工程规划设计时，如何利用三次自然样条插值函数在有限个方案的基础上自动生成无限多个方案，然后采用多目标综合决策模型在其中选择最优方案的一种方法．文中还给出了程序流程，并以某水电站正常蓄水位选择作为实例，对方法进行了验证，结果与专家决策完全吻合．     

新世纪图书馆员社会角色转换研究综述

就近几年图书馆界关于新世纪馆员意识转换及社会角色转换等方面的研究进行了综述，指出新时期的馆员要实现自我社会角色的转换，首先是要明确转换的必要性，然后采取有效的策略逐步地、系统地推进转换，才能取得较好的效果。     

基于RBF网络的增量学习

提出了一种基于径向网络的增量学习算法 ,在对新样本进行学习时 ,通过恢复受干扰样本的方式来尽可能保持已有的知识不变 .模拟实验证明了本算法的正确性和有效性 .     

变电站自动化系统中一种新智能测控装置设计

介绍了变电站自动化系统一种基于80C196KB控制CPU设计的新型线路单元测控装置。它能完成一条线路的遥测、遥信、遥控和遥脉功能。模拟量测量采用基于快速傅里叶变换的交流采样算法，测量精度高。与上位机的通信提供多种选择方式，人机交互采用点阵液晶显示及薄膜式键盘，开关量状态、脉冲量的采集以及控制输出都采用二次隔离技术，并采用了先进软件抗干扰技术，遥控操作可靠。     

Pragmatism in Economic Methodology: The Duhem-Quine Thesis Revisited

Contemporary developments in economicmethodology have produced a vibrant agenda ofcompeting positions. These include, amongothers, constructivism, critical realism andrhetoric, with each contributing to the Realistvs. Pragmatism debate in the philosophies of thesocial sciences. A major development in theneo-pragmatist contribution to economicmethodology has been Quine's pragmatic assaulton the dogmas of empiricism, which are nowclearly acknowledged within contemporaryeconomic methodology. This assault isencapsulated in the celebrated Duhem-Quinethesis, which according to a number ofcontemporary leading philosophers of economics,poses a particularly serious methodologicalproblem for economics. This problem, asreflected in Hausman's analysis, consists ofthe inability of economics to learn fromexperience, thereby subverting the capacity totest economic theories. In this paper wedispute this position. Our argument is basedon a combination of Quine's holism with VanFraassen's constructive empiricism, especiallythe latter's analysis of empirical adequacy andhis pragmatic approach to explanation. Theresulting reorientation of economic methodologyrestores the capacity of economics to learnfrom experience and reinstates the imperativeof developing alternatives to orthodoxtheorizing in economics.