Antifertility activity of trimethylphosphate in male rats

Summary The toxic effect of trimethylphosphate on rat testes was investigated after oral dosing with 250 mg/kg for either 5 days/week for 30 days or 6 days/week for 60 days. After these prolonged treatments azoospermia resulted.Acknowledgments. The authors wish to thank Ms M. Michelles, Ms A. Murray and Ms R. Peake for their technical support.     

Intrauterine device increases the fibrinolytic activity of the rat endometrium at deciduation, a new aspect of its contraceptive effect.

The fibrinolytic activity of the endometrium of the two uterine horns in the rat was histochemically determined. One of the horns contained a plastic-IUD, the other served as control. The endometrium of the control horn was almost inactive in contrast with that of the IUD-horn in which fibrinolytic activity was apparent. The fibrinolytic activity induced by the IUD might be involved in the prevention of ova implantation.     

Effect of chronic hypo and hypervitaminosis C on the brush border enzymes and the intestinal uptake of glucose and alanine

Summary Brush border sucrase and alkaline phosphatase activities are considerably enhanced in the intestine of ascorbic acid deficient guinea-pigs. Similar increase in the uptake of D-glucose and L-alanine also occurs in chronic vitamin C deficiency. However the permeability of D-glucose and L-alanine in the intestine of animals fed with large doses of vitamin C is severely depressed, with a reduction in the levels of sucrase and alkaline phosphatase activities.     

125I-Insulin is preferentially internalized in regions of the hepatocytes rich in lysosomal and Golgi structures

Summary ¹²⁵I-Insulin initially localizes to the plasma membrane of isolated rat hepatocytes but is subsequently internalized and preferentially associates with lysosomal structures. In the present study, we show that this preferential association to lysosomes occurs in regions of the cell rich in lysosomal and Golgi structures.This work was performed while Dr Gorden was visiting professor of the Institute of Histology and Embryology, University of Geneva, Geneva, Switzerland.This work was supported by grant No. 3.120.77 from Swiss National Science Foundation. We thank M.M. Sidler-Ansermet, O. Jerotic and N. Maalaoui for their valuable help.     

Studies on the behaviour of circular dichroism of different haemoglobins in the 260 nm region

Zusammenfassung CD-Messungen mit hoher Auflösung an Hämoglobinen verschiedener Spezies ergaben eine Aufspaltung der breiten Absorptionsbande bei 260 nm in 4 einzelne Maxima. Diese stimmen mit der Bandenlage des Phenylalanins im Absorptionsspektrum vom Hämoglobin gut Überein und werden daher diesem Chromophor zugeordnet.     

Intracellular localization and heterogeneity of alkaline phosphatase of Yoshida ascites sarcoma

Zusammenfassung In Yoshida-Sarkomzellen ist die alkalische Phosphatase vorwiegend in der partikelfreien Fraktion in gelöster Form lokalisiert. Gelfiltration fÜhrt zu einer Auftrennung des Enzyms im partikelfreien Überstand von 6 Fraktionen, des Enzyms in den Zellkernen bei 2 Fraktionen.

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We are grateful to Tenovus (Wales) for financial support.