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151.
152.
M. D. Adams J. T. Earnhardt B. R. Martin L. S. Harris W. L. Dewey R. K. Razdan 《Cellular and molecular life sciences : CMLS》1977,33(9):1204-1205
Summary Abnormal-8-tetrahydrocannabidiol (ABN-8-THC) failed to elicit central nervous system and cardiovascular effects in laboratory animals. Abnormal-cannabidiol (ABN-CBD) was also devoid of overt behavioral effects but produced marked hypotension with only slight bradycardia in anesthesized dogs.Acknowledgment. This work was supported by NIDA (grant No. DA-00574-01 and DA-00490) and Virginia Heart Society (grant No. RR-05697) 相似文献
153.
R. K. Raina D. Njoroge J. N. Ng'ang'a B. V. Telang 《Cellular and molecular life sciences : CMLS》1977,33(11):1499-1500
Summary
Naja mossambica pallida venom administered i.v. (300 /kg) produces an initial brief fall in blood pressure, due to a direct myocardial depressant effect, and a sustained fall due to central depressant effect.This study was supported by University of Nairobi research grants (670–376). We also thank Mr E. Njogu for photographic assistance. 相似文献
154.
Molecular analysis of spontaneous somatic mutants. 总被引:17,自引:0,他引:17
Eukaryotic structural gene mutations occurring spontaneously in a mouse myeloma cell line offer the opportunity to study somatic mutation in animal cells at the molecular level. Studies on the myeloma protein and on mRNA have enabled us to characterise four such mutants representing four different mutation mechanisms. The results may have some bearing on the origin of antibody diversity. 相似文献
155.
156.
Proton pump coupled to cytochrome c oxidase in mitochondria. 总被引:1,自引:0,他引:1
M K Wikstrom 《Nature》1977,266(5599):271-273
157.
L. Minale C. Pizza R. Riccio F. Zollo 《Cellular and molecular life sciences : CMLS》1983,39(6):569-571
Summary On the basis of comparative spectral data, the structures of 3 novel steroidal glycosides from the Mediterranean starfishHacelia attenuata have been elucidated as3, 4 and5. These are further examples of a novel group of 24-O-glycosidated steroids recently encountered in the same species and in the Pacific speciesProtoreaster nodosus.Part 9. L. Minale, C. Pizza, R. Riccio and F. Zollo, Experientia39 (1983) 567. This contribution is part of the Progetto Finalizzato Chimica fine e secondaria del C.N.R., Roma.Acknowledgments. We thank Prof. K. Nakanishi, Columbia University, New York, for FD-mass spectral analyses, the Centro Interfacoltà di Metodologie Chimico-Fisiche for 270 MHz NMR facilities, and Miss R. Aquino for part of the experimental work. 相似文献
158.
Structure,biosynthesis and functions of glycoprotein glycans 总被引:14,自引:0,他引:14
Eric G. Berger Eckhart Buddecke Johannis P. Kamerling Akira Kobata James C. Paulson Johannes F. G. Vliegenthart 《Cellular and molecular life sciences : CMLS》1982,38(10):1129-1162
Since the pioneering work on structure and function of heteroglycans compiled in the classical books edited by A. Gottschalk in 19721, there have been several promising developments in glycoconjugate research, as reviewed in this article.In Part 1, contributed by A. Kobata, current knowledge on heteroglycan structures is presented and representative examples taken from higher organisms are given. Part 2, written by J. F. G. Vliegenthart and J. P. Kamerling, covers the most important achievements in methodology: procedures to obtain pure glycans and to analyze their structures. Part 3, contributed by J. Paulson, is devoted to biosynthesis of glycans now describable as pathways since several of the glycosyltransferases have been isolated and analyzed for specificity. In Part 4, contributed by E. Buddecke, current knowledge on functional roles of glycans is presented. It will become apparent that the prerequisite for valid work either in biosynthetic or functional context depends on solid structural information. This is particularly true whenever glycosyltransferase reaction products are being analyzed, or glycans involved in biological functions are investigated. Although in past years, a great deal of important knowledge has been gathered by use of crude glycosidase or glycosyltransferase activities (a notable example is found in reference 2), one may now postulate that glycans implicated in biological reactions should be thoroughly analyzed.This review may familiarize newcomers with the field of glycoconjugate research with special emphasis on glycoprotein glycans. Glycolipids are not included in this article as they have recently been reviewed by S. I. Hakomori3. The reader is also referred to several excellent monographs4,5 and the Proceedings of the Glycoconjugate Symposia held biannually6–8. 相似文献
159.
I. J. Miller N. K. McCallum C. M. Kirk B. M. Peake 《Cellular and molecular life sciences : CMLS》1982,38(2):230-231
Summary The free radical oxidation of 1 and 6-tetrahydrocannabinol has been examined by spin trapping techniques and intermediates that would lead to cannabinol have been trapped. The 1st step in the oxidation of 1-THC involves the removal of 3-H, while for 6-THC, either 2-H or 5-H. Intermediates were isolated which could be pyrolysed to the diene and cannabinol. 相似文献
160.
F. Imperato 《Cellular and molecular life sciences : CMLS》1982,38(1):67-68
Summary A new chalcone glucoside has been isolated from the flowers ofAcacia dealbata and shown to be 4,2,4,6-tetrahydroxy-3-methoxychalcone 2-O--D-glucoside (1) by chemical degradations and spectroscopic methods. Cernuoside (4,6,3,4-tetrahydroxyaurone 4-O--D-glucoside), (2) has also been found in this plant material.Acknowledgments. The author thanks Prof. H. Wagner, Institut für pharmazeutische Arzneimittellehre der Universität München, for a sample of homoeriodictyol, and Prof. J.B. Harborne, University of Reading, for a sample of aureusidin. 相似文献