Increase of the amount of DNA-feulgen in mammalian tissue by schiff reagents at less acid pH

Zusammenfassung Die Färbbarkeit der DNS mit dem Feulgenreagens nimmt mit steigendem pH des Reagens zu. Es wird nachgewiesen, dass die verstärkte Reaktion alle 3 Bestandteile des gebräuchlichen Fuchsins betrifft.

---

---

The author wishes to record his sincere appreciation to Prof.B. R. Seshachar for providing facilities to carry out this investigation. This work was supported in part by a research grant (GM 10499) from the National Institutes of Health, U.S. Public Health Service, to Prof.B. P. Kaufmann.     

Primary division ratio of umbilical arteries and vein of the human placenta in abnormal states of pregnancy and development

Zusammenfassung Es wird gezeigt, dass die Verzweigungen der Nabelschnurgefässe am übergang auf die Membrana chorii bei Zwillingsschwangerschaften, Fehlbildungen des Fetus sowie beim Hydramnion signifikante Abweichungen von der Norm zeigen.     

Variations in cardiac noradrenaline content during sodium loading in hypertension prone and resistant rats

Summary The cardiac catecholamine content of Sabra rats and their 2 genetically derived substrains, hypertension prone and resistant rats, was studied by high pressure liquid chromatography and electrochemical detection. Both in the control period and after sodium and DOCA administration the cardiac noradrenaline level is higher in hypertension resistant rats than in Sabra rats, and also higher than in hypertension prone rats. This finding suggests that a reduction of the cardiac sympathetic nervous tone is involved in the genetic resistance to sodium.     

Effect of ions on the light-sensitive current in retinal rods

The effect of ions on the light-sensitive current of retinal rods was studied by sucking the inner segment into a tightly fitting capillary with the outer segment projecting into a flowing solution. This new method showed that the light-sensitive pathway, in which Na+ is the normal carrier of current, has an ionic selectivity different from that of other known sodium channels. Externàl calcium has a striking effect on the current, which increased about 20-fold when all calcium was removed. Reducing the sodium concentration gradient greatly prolonged the response to a flash of light, as would be expected if internal calcium blocks sodium channels and if light releases calcium which is subsequently extruded by a sodium-calcium exchange mechanism.     

Kompensation der teratogenen Wirkung eines Thalidomid-Metaboliten durchl-Glutaminsäure

Summary Skeletal defects were observed in the off-spring of SWS-mice following i.p. administration of phthaloyl-l-glutamic acid, a metabolite of thalidomide. The fetuses of animals which receivedl-glutamic acid in addition to the teratogenic drug, did not show any malformations, whereas concurrent i.p. administration of thed-isomer of glutamic acid failed to reverse teratogenicity induced by phthaloyl-l-glutamic acid.