基于目标导向的多属性决策属性价值公度方法

MACBETH方法在多个属性维度上确定出的一组属性Good值(或Neutral值)并不能真地具有保证属性价值公度的完全相同的偏好涵义.为克服该方法缺陷,基于包容性属性价值函数,通过引入数据包络分析技术和马尔可夫理论给出了以目标参照方案为导向的目标导向属性价值函数和多属性决策属性价值公度的方法程序.相比于具有较大随意性确定属性Good值和Neutral值的MACBETH方法,依赖目标导向属性价值函数的多属性决策属性价值公度程序具有更明显的科学合理性,因此具有发展MACBETH方法,推动实际决策应用该方法及相关多属性偏好关联决策模型的创新价值.基于决策实验的应用分析直接验证了多属性决策属性价值公度方法程序的科学有效性,间接验证了包容性属性价值函数和目标导向属性价值函数的科学理性.     

建国初期党对私营文化事业的改造与管理——从陋俗文化改造的视角

建国初期,私营文化事业在一定时期内满足了人民群众对精神文化的需求,但同时也成为陋俗文化得以蔓延的土壤。党和政府对私营文化事业的政策经历了由扶植到改造的变迁。在这一政策的指导下,我国顺利完成了对私营文化的社会主义改造,为党和政府开展对陋俗文化的改造提供了良好的社会条件。对这段历史进行梳理,对于当前正确处理发展国有文化事业与民营文化事业的关系具有重要的启示。     

过度自信委托代理人间的薪酬合同研究

委托-代理模型中，委托人委托代理人销售产品并付给代理人一定的报酬. 委托人和代理人对随机需求的均值或方差的估计存在误差，由此产生绝对过度自信和相对过度自信. 委托人可提供的薪酬合同有两种：线性合同和阈值合同. 在委托人和代理人持有的不同自信度组合中，分别给出了线性合同和阈值合同下的最优参数. 研究得出：对委托人而言，当且仅当其关于不确定性需求方差的信念较代理人悲观，并且对市场需求位于零点附近的可能性的估计较代理人小时，阈值合同优于线性合同；否则，在线性合同和阈值合同下，委托人的均衡期望收益相等.     

Melatonin transport into mitochondria

Melatonin is a well-known, nighttime-produced indole found in bacteria, eukaryotic unicellulars, animals or vascular plants. In vertebrates, melatonin is the major product of the pineal gland, which accounts for its increase in serum during the dark phase, but it is also produced by many other organs and cell types. Such a wide distribution is consistent with its multiple and well-described functions which include from the circadian regulation and adaptation to seasonal variations to immunomodulatory and oncostatic actions in different types of tumors. The discovery of its antioxidant properties in the early 1990s opened a new field of potential protective functions in multiple tissues. A special mention should be made regarding the nervous system, where the indole is considered a major neuroprotector. Furthermore, mitochondria appear as one of the most important targets for the indole’s protective actions. Melatonin’s mechanisms of action vary from the direct molecular interaction with free radicals (free radical scavenger) to the binding to membrane (MLT1A and MLT1B) or nuclear receptors (RZR/RORα). Receptor binding has been associated with some, but not all of the indole functions reported to date. Recently, two new mechanisms of cellular uptake involving the facilitative glucose transporters GLUT/SLC2A and the proton-driven oligopeptide transporter PEPT1/2 have been reported. Here we discuss the potential importance that these newly discovered transport systems could have in determining the actions of melatonin, particularly in the mitochondria. We also argue the relative importance of passive diffusion vs active transport in different parts of the cell.     

Historical review and redescription of three poorly known species of the catfish genus Trichomycterus from south-eastern Brazil (Siluriformes: Trichomycteridae)

ABSTRACT

This study is primarily directed to the most poorly known species of the genus Trichomycterus, comprising five nominal species (T. florensis, T. immaculatus, T. nigricans, T. paquequerensis and T. santaeritae) endemic to south-eastern Brazil. One of them, T. nigricans, is the type species of the genus, involved in taxonomic problems for over 150 years. A detailed historical review, accompanied by examination of type specimens and recent collections, revealed that the correct type locality of T. nigricans is in the vicinity of Rio de Janeiro, not Santa Catarina as commonly appears in the literature; specimens previously misidentified as T. nigricans from Santa Catarina belong to a possibly undescribed species of the genus Cambeva; T. paquequerensis is a synonym of T. immaculatus, and T. florensis is a synonym of T. santaeritae; and the hypothesis that T. santaeritae is closely related to the Amazon Sarcoglanidinae is refuted. The three valid species are redescribed. These species are members of a clade also including T. caipora that is highly supported by molecular data, diagnosed by a pronounced posterior maxillary process and caudal fin emarginate at least in larger specimens. A subclade comprising T. caipora, T. nigricans and T. santaeritae is diagnosed by a long maxilla and a bifid anterior extremity of hypobranchial 3.     

Optimal Multimodel Representation by Laguerre Filters Applied to a Communicating Two Tank System

This paper presents the development of a new nonlinear representation by exploiting the multimodel approach and the new linear representation ARX-Laguerre for each operating region. The resulting multimodel, entitled ARX-Laguerre multimodel, is characterized by the parameter number reduction with a recursive representation. However, a significant reduction of this multimodel is subject to an optimal choice of Laguerre poles characterizing each local linear model ARX-Laguerre. Therefore, the authors propose an optimization algorithm to estimate, from input/output measurements, the optimal values of Laguerre poles. The ARX-Laguerre multimodel as well as the proposed optimization algorithm are tested on a continuous stirred tank reactor system (CSTR). Moreover, the authors take into account a practical validation on an experimental communicating two tank system (CTTS).     

基于正态分布概率模型的渗滤液回灌影响分析

渗滤液回灌能有效加速填埋场的稳定并处理多余的渗滤液, 而预测回灌过程中渗滤液的运移规律对于合理设置回灌井的间距和数量具有重要的意义. 考虑了垃圾体的非均质性, 建立了垃圾体的渗透系数随空间正态分布变化的概率模型. 利用 COMSOL Multiphysics^® 软件, 首先对单孔隙度的横纵向均质模型和正态分布模型的 渗透系数以及压力水头进行了比较, 其次研究了在横纵向渗透系数比值、回灌速率和回灌时间等不同 影响因素下, 均质模型和正态分布模型的含水率以及横向影响范围的变化规律. 结果表明, 随着横纵向渗透系数比值的增加, 最终在 100 d 时: 均质模型的含水率由 0.609 增加到 0.68, 横向影响范围从4.842 m 增加到 6.79 m; 正态分布模型的含水率由 0.573 增加到 0.610, 横向影响范围从4.097 m 变为 4.04 m. 这说明横纵向渗透系数比值对正态分布模型的含水 率和渗滤液横向影响范围的影响明显高于均质模型. 而当回灌速率和回灌时间相同时, 正态分布模型渗滤液的渗流速度更快, 易于优先达到饱和含水率, 并在短暂的峰值后迅速下降, 且随着回灌速率和回灌时间的增加, 达到饱和含水率和峰值的时间也逐渐增加.     

基于高效液相色谱法的牛黄解毒制剂中胆红素含量测定

利用高效液相色谱法建立牛黄解毒制剂中胆红素的含量测定方法,色谱柱为Agilent Zorbax SB-C18色谱柱,流动相为乙腈—1%冰醋酸(95∶5),检测波长为450 nm.结果显示,胆红素进样量在0.8321~208.032 ng范围内具有良好的线性关系,r=0.9995,牛黄解毒片平均回收率为105.6%,RSD为1.42%,牛黄解毒丸平均回收率为96.2%,RSD为1.83%.结果表明,方法准确、简便,可作为牛黄解毒片及牛黄解毒丸等制剂中胆红素含量的测定方法.