Properties and causes: An approach to the problem of hypothesis in the scientific methodology of Sir Isaac Newton

This article considers the differential absorption and integration of refugee physicists into various countries during the 1930s, and the social and intellectual factors responsible for this, focusing particularly on the social functions of the British and American university at that period, as well as continuing ideological struggles in the Soviet Union. More generally, the issue of the relative absorption of refugee physicists is used to examine the nature of the physics communities and other institutions of the host societies.     

The London evening courses of Benjamin Martin and James Ferguson,eighteenth-century lecturers on experimental philosophy

A study of some London newspapers of the early 1770s has shown that Martin and Ferguson gave continuous courses of evening lectures during the winter, in direct competition with each other. In this paper the coverage of their courses is derived from their advertisements, and related to their publications and other activities. In some subjects, such as Electricity, Hydrostatics, and Air-pump Experiments, there was close correspondence between the courses, but others reflected the lecturers' primary interests: for Martin, Optics, and for Ferguson, Mechanics and Astronomy.     

Mutation in the gene encoding ferritin light polypeptide causes dominant adult-onset basal ganglia disease.

We describe here a previously unknown, dominantly inherited, late-onset basal ganglia disease, variably presenting with extrapyramidal features similar to those of Huntington's disease (HD) or parkinsonism. We mapped the disorder, by linkage analysis, to 19q13.3, which contains the gene for ferritin light polypeptide (FTL). We found an adenine insertion at position 460-461 that is predicted to alter carboxy-terminal residues of the gene product. Brain histochemistry disclosed abnormal aggregates of ferritin and iron. Low serum ferritin levels also characterized patients. Ferritin, the main iron storage protein, is composed of 24 subunits of two types (heavy, H and light, L) which form a soluble, hollow sphere. Brain iron deposition increases normally with age, especially in the basal ganglia, and is a suspected causative factor in several neurodegenerative diseases in which it correlates with visible pathology, possibly by its involvement in toxic free-radical reactions. We found the same mutation in five apparently unrelated subjects with similar extrapyramidal symptoms. An abnormality in ferritin strongly indicates a primary function for iron in the pathogenesis of this new disease, for which we propose the name 'neuroferritinopathy'.     

Chemistry and slavery in the Scottish Enlightenment

ABSTRACT

The Scottish Enlightenment has long been identified with abolitionism because of the writings of the moral and economic philosophers and the absence of slaves in Scotland itself. However, Scots were disproportionately represented in the ownership, management, and especially medical treatment of slaves in the British Caribbean. Sugar and cotton flowed into Glasgow and young, educated Scots looking for work as traders, bookkeepers, doctors made the return trip back to the Caribbean to manage the plantations. Chemically trained doctors and agriculturalists tested their theories in the plantations and developed new theories based on their experimentation on the land and slaves. In foregrounding the participation of Scottish trained chemists in the practice of slavery, I argue that the development of eighteenth-century chemistry and the broader intellectual Enlightenment were inextricably entangled with the economic Improvement Movement and the colonial economy of the British slave trade.     

Fertile island development around perennial shrubs across a Mojave Desert chronosequence

Spatial heterogeneity has been examined only recently as a factor in studies of ecosystem processes. The effect of this factor on desert organisms is exemplified in the ""fertile island"" a concentration of essential soil nutrients under perennial shrubs. In this study we examined fertile island patterns in undisturbed desert areas and on abandoned roadways to see at what rate and magnitude these fertile patches reappeared after disturbance. Small-scale examination of patterns of soil P, organic matter, moisture, and bulk density showed that soils beneath Larrea tridentata (DC.) Cov. shrubs on the roads lacked the tight circular gradient in these variables that was characteristic of soils beneath control shrubs, even 88 years after road abandonment. The nature of the initial soil disturbance altered both spatial patterns of soil N and temporal patterns of fertile island development. Fertile island patterns for total soil N, available P, and organic matter were more circular than patterns for bulk density, texture, or pH. We suggest that patterns of soil heterogeneity may develop first for elements that may be limiting to desert shrub growth (N, P, organic matter), followed by spatial development in other less limiting soil factors (bulk density, texture, pH).     

Dispersal of sagebrush-steppe seeds by the western harvester ant ( Pogonomyrmex occidentalis )

Like many seed-harvesting ants, the western harvester ant ( Pogonomyrmex occidentalis ) can act as both a predator and a seed disperser. Dispersal results when seeds are dropped en route to the nest, are left in nest granaries when colonies die or are abandoned, or are removed from granaries and discarded in nest middens. This study examined the density and species identity of seeds discarded in harvester ant nest middens and compared them with those found in nearby soils. Nineteen species of seeds were recovered from middens, compared with 13 species in 5-m reference areas and 9 species in adjacent disk areas. Total density of sound seeds was nearly 3 times higher in middens than at 5 m from the nest and nearly 50 times higher than in disk soils. Moreover, 4 of the 6 most common species overall were significantly more abundant in middens. One species, Munro globemallow ( Sphaeralcea munroana ), was recovered from nearly 50% of middens but was not found in the other 2 areas. These findings suggest that the western harvester ant is a potentially important disperser of some sagebrush-steppe plant species.     

Using Neural Network Analysis to Define Methods of DINA Model Estimation for Small Sample Sizes

The DINA model is a commonly used model for obtaining diagnostic information. Like many other Diagnostic Classification Models (DCMs), it can require a large sample size to obtain reliable item and examinee parameter estimation. Neural Network (NN) analysis is a classification method that uses a training dataset for calibration. As a result, if this training dataset is determined theoretically, as was the case in Gierl’s attribute hierarchical method (AHM), the NN analysis does not have any sample size requirements. However, a NN approach does not provide traditional item parameters of a DCM or allow for item responses to influence test calibration. In this paper, the NN approach will be implemented for the DINA model estimation to explore its effectiveness as a classification method beyond its use in AHM. The accuracy of the NN approach across different sample sizes, item quality and Q-matrix complexity is described in the DINA model context. Then, a Markov Chain Monte Carlo (MCMC) estimation algorithm and Joint Maximum Likelihood Estimation is used to extend the NN approach so that item parameters associated with the DINA model are obtained while allowing examinee responses to influence the test calibration. The results derived by the NN, the combination of MCMC and NN (NN MCMC) and the combination of JMLE and NN are compared with that of the well-established Hierarchical MCMC procedure and JMLE with a uniform prior on the attribute profile to illustrate their strength and weakness.     

Platelets and innate immunity

Although platelets are best known as primary mediators of hemostasis, this function intimately associates them with inflammatory processes, and it has been increasingly recognized that platelets play an active role in both innate and adaptive immunity. For example, platelet adhesive interactions with leukocytes and endothelial cells via P-selectin can lead to several pro-inflammatory events, including leukocyte rolling and activation, production of cytokine cascades, and recruitment of the leukocytes to sites of tissue damage. Superimposed on this, platelets express immunologically-related molecules such as CD40L and Toll-like receptors that have been shown to functionally modulate innate immunity. Furthermore, platelets themselves can interact with microorganisms, and several viruses have been shown to cross-react immunologically with platelet antigens. This review discusses the central role that platelets play in inflammation, linking them with varied pathological conditions, such as atherosclerosis, sepsis, and immune thrombocytopenic purpura, and suggests that platelets also act as primary mediators of our innate defences.     

Production TTR modeling and dynamic buckling analysis

In a typical tension leg platform (TLP) design,the top tension factor (TTF),measuring the top tension of a top tensioned riser (TTR) relative to its submerged weight in water,is one of the most important design parameters that has to be specified properly. While a very small TTF may lead to excessive vortex induced vibration (VIV),clashing issues and possible compression close to seafloor,an unnecessarily high TTF may translate into excessive riser cost and vessel payload,and even has impacts on the TLP sizing and design in general. In the process of a production TTR design,it is found that its outer casing can be subjected to compression in a worst-case scenario with some extreme metocean and hardware conditions. The present paper shows how finite element analysis (FEA) models using beam elements and two different software packages (Flexcom and ABAQUS) are constructed to simulate the TTR properly,and especially the pipe-in-pipe effects. An ABAQUS model with hybrid elements (beam elements globally + shell elements locally) can be used to investigate how the outer casing behaves under compression. It is shown for the specified TTR design,even with its outer casing being under some local compression in the worst-case scenario,dynamic buckling would not occur;therefore the TTR design is adequate.