Whole-genome analysis informs breast cancer response to aromatase inhibition

To correlate the variable clinical features of oestrogen-receptor-positive breast cancer with somatic alterations, we studied pretreatment tumour biopsies accrued from patients in two studies of neoadjuvant aromatase inhibitor therapy by massively parallel sequencing and analysis. Eighteen significantly mutated genes were identified, including five genes (RUNX1, CBFB, MYH9, MLL3 and SF3B1) previously linked to haematopoietic disorders. Mutant MAP3K1 was associated with luminal A status, low-grade histology and low proliferation rates, whereas mutant TP53 was associated with the opposite pattern. Moreover, mutant GATA3 correlated with suppression of proliferation upon aromatase inhibitor treatment. Pathway analysis demonstrated that mutations in MAP2K4, a MAP3K1 substrate, produced similar perturbations as MAP3K1 loss. Distinct phenotypes in oestrogen-receptor-positive breast cancer are associated with specific patterns of somatic mutations that map into cellular pathways linked to tumour biology, but most recurrent mutations are relatively infrequent. Prospective clinical trials based on these findings will require comprehensive genome sequencing.     

Engineered two-dimensional Ising interactions in a trapped-ion quantum simulator with hundreds of spins

The presence of long-range quantum spin correlations underlies a variety of physical phenomena in condensed-matter systems, potentially including high-temperature superconductivity. However, many properties of exotic, strongly correlated spin systems, such as spin liquids, have proved difficult to study, in part because calculations involving N-body entanglement become intractable for as few as N?≈?30 particles. Feynman predicted that a quantum simulator--a special-purpose 'analogue' processor built using quantum bits (qubits)--would be inherently suited to solving such problems. In the context of quantum magnetism, a number of experiments have demonstrated the feasibility of this approach, but simulations allowing controlled, tunable interactions between spins localized on two- or three-dimensional lattices of more than a few tens of qubits have yet to be demonstrated, in part because of the technical challenge of realizing large-scale qubit arrays. Here we demonstrate a variable-range Ising-type spin-spin interaction, J(i,j), on a naturally occurring, two-dimensional triangular crystal lattice of hundreds of spin-half particles (beryllium ions stored in a Penning trap). This is a computationally relevant scale more than an order of magnitude larger than previous experiments. We show that a spin-dependent optical dipole force can produce an antiferromagnetic interaction J(i,j) proportional variant d(-a)(i,j), where 0?≤?a?≤?3 and d(i,j) is the distance between spin pairs. These power laws correspond physically to infinite-range (a = 0), Coulomb-like (a = 1), monopole-dipole (a = 2) and dipole-dipole (a = 3) couplings. Experimentally, we demonstrate excellent agreement with a theory for 0.05???a???1.4. This demonstration, coupled with the high spin count, excellent quantum control and low technical complexity of the Penning trap, brings within reach the simulation of otherwise computationally intractable problems in quantum magnetism.     

基于遥感与区域化方法的无资料流域水文模型参数优化方法

针对无资料流域径流预报的难点, 探讨水文模型参数优化的共性问题, 综述区域化方法和遥感方法的研究现状。首先从水文模型参数优化面临的共性问题, 即水文地理数据生成、目标函数构建和优化方法选择等问题出发, 分析其对参数优选结果的影响, 并归纳出当前广泛认可的解决方案。然后结合区域化方法的技术原理和研究进展, 着重论述测站密度对区域化方法性能的影响, 并分析该方法在中国的适用性。接着从研究区域、水文模型结构、遥感资料以及率定目标等方面归纳总结遥感方法优化水文模型参数的最新研究进展。最后对区域化方法和遥感方法的优缺点及未来发展前景进行对比分析, 为中国无资料或缺资料流域径流预报实践提供参考。     

Effects of anisotropy on time-depth relation in transversely isotropic medium with a vertical axis of symmetry

It is known that rock anisotropy can significantly influence the phase and energy velocities of an elastic wave, as well as its re-flection/transmission (R/T) coefficients. As a result, it can distort the velocity analysis of seismic-reflection data. In this work we present a velocity analysis for seismic-reflection data based on the available anisotropic rock parameters. We analyzed the created errors on time-depth relation of the seismic-reflection data in neglecting rock anisotropy and/or neglecting the difference between energy velocity and phase velocity, including the case of wide-angle reflection. The calculated results show that the effect of rock anisotropy on time-depth relation of seismic-reflection data is dependent not only on the values of anisotropic parameters, but also on the space arrangement of both source and receiver-array. For all studied cases (weak, moderate or strong anisotropy), we found that the effect of rock anisotropy on time-depth relation could not be neglected. Nevertheless, for the case of weak anisotropy, the energy velocity may be replaceable by the phase velocity to obtain a very good approximation on time-depth relation. Consequently, the seismic-reflection data processing algorithm for numerical computations can be simplified.