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排序方式: 共有291条查询结果,搜索用时 15 毫秒
101.
Delphine Meffre Julien Grenier Sophie Bernard Françoise Courtin Todor Dudev Ghjuvan’Ghjacumu Shackleford Mehrnaz Jafarian-Tehrani Charbel Massaad 《Cellular and molecular life sciences : CMLS》2014,71(7):1123-1148
Wnt signaling is required for neurogenesis, the fate of neural progenitors, the formation of neuronal circuits during development, neuron positioning and polarization, axon and dendrite development and finally for synaptogenesis. This signaling pathway is also implicated in the generation and differentiation of glial cells. In this review, we describe the mechanisms of action of Wnt signaling pathways and their implication in the development and correct functioning of the nervous system. We also illustrate how a dysregulated Wnt pathway could lead to psychiatric, neurodegenerative and demyelinating pathologies. Lithium, used for the treatment of bipolar disease, inhibits GSK3β, a central enzyme of the Wnt/β-catenin pathway. Thus, lithium could, to some extent, mimic Wnt pathway. We highlight the possible dialogue between lithium therapy and modulation of Wnt pathway in the treatment of the diseases of the nervous system. 相似文献
102.
The following species of the fly genus Lispe are redescribed: L. albitarsis (Stein, 1898), L. latana Snyder, 1949, L. levis (Stein, 1911), L. lisarba Snyder, 1949, L. nasoni (Stein, 1898), L. serotina Wulp, 1896, L. setuligera (Stein, 1911) and L. vilis (Stein, 1911). Additionally, a new diagnosis is proposed for L. rufitibialis Macquart, 1843, and in order to fix the identity of the name the lectotype is designated. To facilitate species identification, a pictorial key for the species of Lispe in the Neotropical region and distribution maps are presented, together with the first published illustrations of the male terminalia of L. latana, L. levis and L. lisarba, and the female of L. lisarba. 相似文献
103.
Sthefane D’ávila Camilla Medeiros Tércia Vargas Cristiane Lafetá Furtado Mendonça 《Journal of Natural History》2018,52(23-24):1551-1569
In the present study, we aimed to characterize the life history of the land snail Subulina octona integrating information on life-history traits and morphology. We also compared the histology of the free-oviduct and spermoviduct of ovoviviparous and egg-retaining species of subulinids. We considered as ovoviviparous the species in which the complete embryonic development as well as egg hatching occurs inside the parent’s body and, at the end of this process, the parent releases juveniles instead of eggs. We considered as egg-retaining the species in which a great part of the embryonic development takes place inside the parent’s body and the eggs laid contain well-developed embryos. The results showed that the free-oviduct of both ovoviviparous and egg-retaining species shows a histological arrangement that confers greater strength to its walls and is probably related to egg retention. The wall of the spermoviduct is formed by pseudostratified columnar epithelium, with cell apical processes (probably cilia), and by underlying secretory cells. In gravid egg-retaining snails, the eggshells appear in close contact with the secretory cells of the spermoviduct. This fact suggests that these cells play a role in eggshell formation. The present study is the first account for histological features of S. octona, Allopeas gracile and Allopeas micra. The life history of S. octona is a combination of long lifespan, early sexual maturity, indeterminate growth and egg retention. Egg retention limits the number of young that can be produced in one reproductive event. However, the reproductive strategy adopted by S. octona, associating egg retention and K-strategism, compensates this cost of retaining eggs, because the reproductive success may be enhanced as a result of the higher survival of juveniles and the possibility of performing several reproductive events during the year. 相似文献
104.
105.
Timm Schubert Corinna Gleiser Peter Heiduschka Christoph Franz Kerstin Nagel-Wolfrum Ayse Sahaboglu Nicole Weisschuh Gordon Eske Karin Rohbock Norman Rieger François Paquet-Durand Bernd Wissinger Uwe Wolfrum Bernhard Hirt Wibke Singer Lukas Rüttiger Ulrike Zimmermann Marlies Knipper 《Cellular and molecular life sciences : CMLS》2015,72(20):3953-3969
106.
107.
G. Mathé P. Pouillart Françoise Lapeyraque 《Cellular and molecular life sciences : CMLS》1971,27(4):446-447
Résumé L'immunothérapie active non spécifique ou mixte, appliquée 24 h après la greffe isogénique de la leucémie RC 19, possède une action considérable; appliquée dans les mêmes conditions après la greffe de la leucémie E K1, elle possède une action modérée mais significative. Ces résultats confirment l'effet antileucémique de l'immunothérapie active appliquée après le début de la maladie et montre qu'elle est même efficace sur les cellules tumorales disséminées.
This work has been carried out with the aid of INSERM, contract No. 66-235. 相似文献
This work has been carried out with the aid of INSERM, contract No. 66-235. 相似文献
108.
109.
Maria Luiza Beçak Sylvia Mendes Carneiro K. Fukuda 《Cellular and molecular life sciences : CMLS》1978,34(2):171-173
Summary We describe the production of circles in chromomeric loops during the pachytene stage of the spermatocytes. These circles are found attached to chromatin or already free in the nucleoplasm. Each circle measures an average of 3700 Å in circunference. We suggest that such circles might indicate the presence of tandem repetitions.This work was supported by grants from Brazilian National Research Council-CNPq, Fundaçaó de Amparo à Pesquisa do Estado de S. Paulo-FAPESP and Instituto Butantan Research Found-FEDIB.We are grateful to Dr A. Brunner, Jr, for the permission to use the electron microscope. 相似文献
110.
A. S. Etienne J. Vauclair E. Emmanuelli M. Lançon J. Stryjenski 《Cellular and molecular life sciences : CMLS》1982,38(5):553-555
Summary Golden hamsters placed on a jumping stand from which they can descend onto a shallow or deep landing platform prefer to descend
on to the shallow platform, even when tested under IR-light without tactile cues. This preference disappears for subjects
with plugged ears. The simultaneous recording of the animal's behaviour and possible emission of ultrasound as well as experiments
in which the external acoustical conditions or the sound-reflecting properties of the jumping apparatus were altered suggest
that the animals use certain parameters of the ambient sound field for depth perception.
Acknowledgments. This research was supported by the Fonds National Suisse de la Recherche Scientifique, grant No. 3.349.74. 相似文献