The kidney and fibrinolysis in man

Zusammenfassung Während Nierenoperationen vorgenommene Messungen ergaben, dass eine in der Funktion stark eingeschränkte Niere weniger Urokinase in den Urin ausscheidet, ohne dass jedoch die fibrinolytische Aktivität im Venenblut zunimmt. Es wird daraus geschlossen, dass die Nieren keine erheblichen Mengen Plasminogen-aktivierender Stoffe an das Blut abgeben.

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This study was supported in part by a grant from the Polish Academy of Sciences. — The authors are deeply indebted to Dr.A. Szkodny for his valuable help in taking blood samples during surgery.     

Effect of ambient cold on urine concentration by the intact and denervated dog kidney

Summary In dogs transferred from room temperature to a low temperature of 1±(SD) 3.5°C, the plasma norepinephrine (NE) level increased significantly. Urine concentration decreased in the cold, in the intact and similarly in the chronically denervated kidney. After return to a warm environment urine concentration improved in both kidneys while plasma NE remained elevated. The data speak against an essential role of the renal nerves in the adaptation of renal function to ambient cold.Acknowledgments. We are greatly indebted to Dr J. Kurkus and Dr R. Gellert who performed the operations of surgical bladder division, and to Mrs W. Radziszewska for determination of plasma norepinephrine. The study was supported within the national research problem No. 10.4.     

Pyruvate kinase inhibited by L-cysteine as a marker of tumorigenic human urothelial cell lines

It was found that a decrease in electrophoretic mobility of pyruvate kinase (PK) isoenzyme, and an increase of the sensitivity of this enzyme to L-cysteine, were markers of immortalization and tumorigenic properties, respectively, in human urothelial cell lines characterized by different grades of transformation (TGr) in vitro.     

Somatostatin inhibits the mitogenic effect of thyroliberin

Summary The effect of somatostatin and of thyroliberin on the mitotic incidence in the organ-cultured anterior pituitary lobe of the rat was investigated, using the colchicine metaphase-arrest technique. It was found that somatostatin added to the culture medium, together with thyroliberin, blocked the mitogenic effect of the latter.This work was supported by Polish Academy of Sciences, program No 10. 4.     

Aging of the erythrocyte. III. Cation content

Summary Studies on the main cation content of density-separated bovine erythrocytes showed a progressive decrease in the levels of K⁺ and Mg²⁺ with increasing cell density (and age) accompanied by an increase in the level of Na⁺. The magnitude of net cation loss corresponded to that of red cell volume decrease, but could not account for the total increase in the microviscosity of the erythrocyte interior.     

Adsorption of hageman factor (factor XII) on collagen

Résumé Nous avons trouvé que le facteur Hageman (factor XII), contenu dans le plasma humain citraté, pauvre en plaquettes, est adsorbé presque sélectivement par le collagène. Il est également possible d'éluer ce facteur au pH alcalin.     

The effect of inhalatory adaptation to histamine on histamine shock and the anaphylactic shock

Résumé Les animaux adaptés à l'histamine sont moins sensible à l'histamine et aux produits d'une réaction antigène-anticorps. La tolérance des cobayes adaptés est augmentée particulièrement après une exposition supplémentaire dans l'aérosol histaminique.     

Der Einbau von radioaktiv markiertem Schwefel (35S) in den Knorpel normaler und Vitamin-C-frei ernährter Meerschweinchen

Summary The utilization of sulphate labelled with S³⁵ to the synthesis of chondroitin sulphate of the cartilage of normal and scorbutic guinea pigs has been examined. The average incorporation of S³⁵ in the costal cartilage in the deficient animal was about one half that of the normal.